Perfil epidemiológico de niños y adolescentes con COVID-19: revisión del alcance

Bernardino, Fabiane Blanco Silva; Alencastro, Lidiane Cristina da Silva; Silva, Ronaldo Antonio da; Ribeiro, Antonia Dinágila do Nascimento; Castilho, Geovane Roberto de Campos; Gaíva, Maria Aparecida Munhoz

Fabiane Blanco Silva Bernardino

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

https://orcid.org/0000-0003-0339-9451

Lidiane Cristina da Silva Alencastro

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

https://orcid.org/0000-0003-3005-415X

Ronaldo Antonio da Silva

Universidade do Estado de Mato Grosso. Diamantino, Mato Grosso, Brazil.

https://orcid.org/0000-0002-1962-3182

Antonia Dinágila do Nascimento Ribeiro

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

https://orcid.org/0000-0001-7852-9199

Geovane Roberto de Campos Castilho

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

https://orcid.org/0000-0002-6300-1479

Maria Aparecida Munhoz Gaíva

Universidade Federal de Mato Grosso. Cuiabá, Mato Grosso, Brazil.

https://orcid.org/0000-0002-8666-9738

Corresponding author: Fabiane Blanco Silva Bernardino E-mail: fabianeblanco25@gmail.com

EDITOR IN CHIEF: Dulce Barbosa

ASSOCIATE EDITOR: Priscilla Broca

Database	Search strategy	Total
PubMed/ MEDLINE	"Infant, newborn" OR "Infant" OR "Children, preschool" OR "Child" OR "Adolescent" AND "Health profile" AND "Risk factors" AND "Mortality" AND "morbidity" AND "COVID-19 virus" OR "SARS-CoV-2" OR "2019-nCoV" OR "coronavirus disease 2019"	868
CINAHL	"Infant, newborn" AND "Infant" AND "Children, preschool" AND "Child" AND "Adolescent" AND "Health profile" AND "Risk factors" AND "Mortality" AND "morbidity" AND "COVID-19 virus" OR "SARS-CoV-2" OR "2019-nCoV" OR "coronavirus disease 2019"	43
Web of Science	"Infant, newborn" AND "Infant" AND "Children, preschool" AND "Child" AND "Adolescent" AND "Health profile" AND "Risk factors" AND "Mortality" AND "morbidity" AND "COVID-19 virus" OR "SARS-CoV-2" OR "2019-nCoV" OR "coronavirus disease 2019"	481
Scopus	"Infant, newborn" OR "Children, preschool" AND "Adolescent" AND "Mortality" OR "morbidity" AND "COVID-19 virus" OR "SARS-CoV-2" OR "2019-nCoV" OR "coronavirus disease 2019"	4
Science direct	"Infant, newborn" OR "Child" AND "Adolescent" AND "Mortality" AND "morbidity" AND "COVID-19 virus" OR "SARS-CoV-2" OR "2019-nCoV" OR "coronavirus disease 2019"	446
Google Scholar	"Child" OR "Adolescent" AND "Mortality" AND "morbidity" AND "COVID-19 virus"	59

Authors	Country	Type of study	Number of children and adolescents
Zheng et al.,⁽⁽⁸8 Zheng F, Liao C, Fan Q, Chen H, Zhao X, Xie Z, et al. Clinical characteristics of children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020;40(2):1-6. doi: 10.1007/s11596-020-2172-6 https://doi.org/10.1007/s11596-020-2172-... ⁾⁾	China	Cross-sectional	25 children
Dong et al.,⁽⁽¹¹11 Dong N, Cai J, Zhou Y, Liu J, Li F. End-stage Heart Failure with COVID-19: strong evidence of myocardial injury by 2019-nCoV. JACC: Heart Failure. 2020. doi: 10.1016/j.jchf.2020.04.001 https://doi.org/10.1016/j.jchf.2020.04.0... ⁾⁾	China	NS	01 adolescent^* * Studies that included other age groups as participants; NS - not specified. ⁾
Escalera-Antezana et al.,⁽⁽¹²12 Escalera-Antezana JP, Lizon-Ferrufino NF, Maldonado-Alanoca A, Alarcón-De-la-Vega G, Alvarado-Arnez LE, Balderrama-Saavedra MA, et al. Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain. Travel Med Infect Dis. 2020. doi: 10.1016/j.tmaid.2020.101653 https://doi.org/10.1016/j.tmaid.2020.101... ⁾⁾	Bolivia	Cross-sectional	02 adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Díaz et al.,⁽⁽¹³13 Díaz CA, Maestro ML, Pumarega MTM, Antón BF, Alonso CRP. Primer caso de infección neonatal por SARS-CoV-2 en España. An Pediatr. 2020;92(4):237-8. doi: 10.1016/j.anpedi.2020.03.002 https://doi.org/10.1016/j.anpedi.2020.03... ⁾⁾	Spain	Clinical case	01 child
Chen et al.,⁽⁽¹⁴14 Chen C, Gao G, Xu Y, Pu L, Wang Q, Wang L, et al. SARS-CoV-2-Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19. Ann Intern Med. 2020;M20-0991. doi: 10.7326/M20-0991 https://doi.org/10.7326/M20-0991... ⁾⁾	China	NS	04 children^* * Studies that included other age groups as participants; NS - not specified. ⁾
Xiang et al.,⁽⁽¹⁵15 Xiang M, Liang S, Zhang Y, Zhang X, Gai Z, Zhang Z. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol, Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.010 https://doi.org/10.1016/j.jmii.2020.03.0... ⁾⁾	China	NS	06 children^* * Studies that included other age groups as participants; NS - not specified. ⁾
Peng e Zhang⁽⁽¹⁶16 Peng A, Zhang M. Novel coronavirus SARS-CoV-2: familial spread resulting in COVID-19 pneumonia in a pediatric patient. Diagn Interv Radiol. 2020;26(3):262-3. doi: 10.5152/dir.2020.20157 https://doi.org/10.5152/dir.2020.20157... ⁾⁾	China	NS	01 child
Park et al.⁽⁽¹⁷17 Park JY, Han MS, Park KU, Kim JY, Choi EH. First Pediatric Case of Coronavirus Disease 2019 in Korea. J Korean Med Sci. 2020;35(11):e124. doi: 10.3346/jkms.2020.35.e124 https://doi.org/10.3346/jkms.2020.35.e12... ⁾⁾	Korea	Clinical case	01 child
Lu et al.⁽⁽¹⁸18 Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. New England J Med. 2020;382(17):1663-5. doi: 10.1056/NEJMc2005073 https://doi.org/10.1056/NEJMc2005073... ⁾⁾	China	NS	171 children and adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Ng et al.⁽⁽¹⁹19 Ng O-T, Marimuthu K, Chia P-Y, Koh V, Chiew CJ, De Wang L, et al. SARS-CoV-2 Infection among Travelers Returning from Wuhan, China. N Engl J Med. 2020;382(15):1476-8. doi: 10.1056/NEJMc2003100 https://doi.org/10.1056/NEJMc2003100... ⁾⁾	China	NS	01 adolescent^* * Studies that included other age groups as participants; NS - not specified. ⁾
Wang et al.⁽⁽²⁰20 Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa225 https://doi.org/10.1093/cid/ciaa225... ⁾⁾	China	Clinical case	01 child
Cao et al.⁽⁽²¹21 Cao Q, Chen Y-C, Chen C-L, Chiu C-H. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formosan Med Assoc. 2020;119(3):670-3. doi: 10.1016/j.jfma.2020.02.009 https://doi.org/10.1016/j.jfma.2020.02.0... ⁾⁾	China	NS	02 children
Guan et al.⁽⁽²²22 Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. doi: 10.1056/NEJMoa2002032 https://doi.org/10.1056/NEJMoa2002032... ⁾⁾	China	Cross-sectional	09 children and adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Mansour et al.,⁽⁽²³23 Mansour A, Atoui R, Kanso K, Mohsen R, Fares Y, Fares J. First Case of an Infant with COVID-19 in the Middle East. Cureus. 2020. doi: 10.7759/cureus.7520 https://doi.org/10.7759/cureus.7520... ⁾⁾	Lebanon	Clinical case	01 child
Pan et al.⁽⁽²⁴24 Pan X, Chen D, Xia Y, Wu X, Li T, Ou X, et al. Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect Dis. 2020;20(4):410-1. doi: 10.1016/S1473-3099(20)30114-6 https://doi.org/10.1016/S1473-3099(20)30... ⁾⁾	China	Clinical case	01 child^* * Studies that included other age groups as participants; NS - not specified. ⁾
Sun et al.⁽⁽²⁵25 Sun D, Li H, Lu X-X, Xiao H, Ren J, Zhang F-R, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study. World J Pediatr. 2020. doi: 10.1007/s12519-020-00354-4 https://doi.org/10.1007/s12519-020-00354... ⁾⁾	China	Cross-sectional	08 children and adolescents
Xu et al.,⁽⁽²⁶26 Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-5. doi: 10.1038/s41591-020-0817-4 https://doi.org/10.1038/s41591-020-0817-... ⁾⁾	China	Cross-sectional	10 children and adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Shi et al.,⁽⁽²⁷27 Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020;8(5):241-241. doi: 10.21037/atm.2020.03.22 https://doi.org/10.21037/atm.2020.03.22... ⁾⁾	China	Cross-sectional	10 children and adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Su et al.,⁽⁽²⁸28 Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19. Emerg Micr Infect. 2020;9(1):707-13. doi: 10.1080/22221751.2020.1744483 https://doi.org/10.1080/22221751.2020.17... ⁾⁾	China	Cross-sectional	09 children^* * Studies that included other age groups as participants; NS - not specified. ⁾
Tan et al.,⁽⁽²⁹29 Tan Y, Tan B, Pan J, Wu J, Zeng S, Wei H. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. J Clin Virol. 2020;127:104353. doi: 10.1016/j.jcv.2020.104353 https://doi.org/10.1016/j.jcv.2020.10435... ⁾⁾	China	Cross-sectional	10 children and adolescents
Xing et al.,⁽⁽³⁰30 Xing Y-H, Ni W, Wu Q, Li W-J, Li G-J, Wang W-D, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. J Microbiol, Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.021 https://doi.org/10.1016/j.jmii.2020.03.0... ⁾⁾	China	Cross-sectional	3 children
Yin et al.,⁽⁽³¹31 Yin X, Dong L, Zhang Y, Bian W, Li H. A mild type of childhood Covid-19: a case report. Radiol Infect Dis. 2020. doi: 10.1016/j.jrid.2020.03.004 https://doi.org/10.1016/j.jrid.2020.03.0... ⁾⁾	China	Cross-sectional	1 child
Chen et al.,⁽⁽³²32 Chen J, Zhang Z-Z, Chen Y-K, Long Q-X, Tian W-G, Deng H-J, et al. The clinical and immunological features of pediatric COVID-19 patients in China. Genes Dis. 2020. doi: 10.1016/j.gendis.2020.03.008 https://doi.org/10.1016/j.gendis.2020.03... ⁾⁾	China	Cross-sectional	12 children and adolescents^* * Studies that included other age groups as participants; NS - not specified. ⁾
Morey-Olivé et al.,⁽⁽³³33 Morey-Olivé M, Espiau M, Mercadal-Hally M, Lera-Carballo E, García-Patos V. Manifestaciones cutáneas en contexto del brote actual de enfermedad por coronavirus 2019. An Pediatr. 2020. doi: 10.1016/j.anpedi.2020.04.013 https://doi.org/10.1016/j.anpedi.2020.04... ⁾⁾	Spain	Clinical cases	2 children
Liu et al.,⁽⁽³⁴34 Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: focus on pregnant women and children. J Infect. 2020;80(5):e7-13. doi: 10.1016/j.jinf.2020.03.007 https://doi.org/10.1016/j.jinf.2020.03.0... ⁾⁾	China	Cross-sectional	04 children^* * Studies that included other age groups as participants; NS - not specified. ⁾
Chacón-Aguilar et al.,⁽⁽³⁵35 Chacón-Aguilar R, Osorio-Cámara JM, Sanjurjo-Jimenez I, González-González C, López-Carnero J, Agapito BP-M-. COVID 19: sindrome febril y clínica neurólogica en neonato. An Pediatr. 2020. doi: 10.1016/j.anpedi.2020.04.012 https://doi.org/10.1016/j.anpedi.2020.04... ⁾⁾	Spain	Clinical cases	01 child
Ji et al.,⁽⁽³⁶36 Ji L-N, Chao S, Wang Y-J, Li X-J, Mu X-D, Lin M-G, et al. Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. World J Pediatr. 2020. doi: 10.1007/s12519-020-00356-2 https://doi.org/10.1007/s12519-020-00356... ⁾⁾	China	Clinical cases	01 child and 01 adolescent
Cai et al.,⁽⁽³⁷37 Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;ciaa198. doi: 10.1093/cid/ciaa198 https://doi.org/10.1093/cid/ciaa198... ⁾⁾	China	NS	10 children and adolescents
Dong et al.,⁽⁽³⁸38 Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020. doi: 10.1542/peds.2020-0702 https://doi.org/10.1542/peds.2020-0702... ⁾⁾	China	NS	2135 children and adolescents
Xia et al.,⁽⁽³⁹39 Xia W, Shao J, Guo Y, Peng X, Li Z, Hu D. Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults. Pediatr Pulmonol. 2020;55(5):1169-74. doi: 10.1002/ppul.24718 https://doi.org/10.1002/ppul.24718... ⁾⁾	China	NS	20 children and adolescents
Zhu et al.,⁽⁽⁴⁰40 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51-60. doi: 10.21037/tp.2020.02.06 https://doi.org/10.21037/tp.2020.02.06... ⁾⁾	China	Cross-sectional	10 children
Wei, et al.,⁽⁽⁴¹41 Wei M, Yuan J, Liu Y, Fu T, Yu X, Zhang Z-J. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323(13):1313. doi: 10.1001/jama.2020.2131 https://doi.org/10.1001/jama.2020.2131... ⁾⁾	China	Cross-sectional	09 children

Authors	Age group	Probable contamination of the disease	Pre-existing disease/condition	Hospitalization/ length (days)
Zheng et al.,⁽⁽⁸8 Zheng F, Liao C, Fan Q, Chen H, Zhao X, Xie Z, et al. Clinical characteristics of children with Coronavirus Disease 2019 in Hubei, China. Curr Med Sci. 2020;40(2):1-6. doi: 10.1007/s11596-020-2172-6 https://doi.org/10.1007/s11596-020-2172-... ⁾⁾	0 - 6y	Travel history	Suspected hereditary metabolic diseases and congenital heart disease	Yes/10
Dong et al.,⁽⁽¹¹11 Dong N, Cai J, Zhou Y, Liu J, Li F. End-stage Heart Failure with COVID-19: strong evidence of myocardial injury by 2019-nCoV. JACC: Heart Failure. 2020. doi: 10.1016/j.jchf.2020.04.001 https://doi.org/10.1016/j.jchf.2020.04.0... ⁾⁾	11y	NS	Heart failure	Yes/NS
Escalera-Antezana et al.,⁽⁽¹²12 Escalera-Antezana JP, Lizon-Ferrufino NF, Maldonado-Alanoca A, Alarcón-De-la-Vega G, Alvarado-Arnez LE, Balderrama-Saavedra MA, et al. Clinical features of the first cases and a cluster of Coronavirus Disease 2019 (COVID-19) in Bolivia imported from Italy and Spain. Travel Med Infect Dis. 2020. doi: 10.1016/j.tmaid.2020.101653 https://doi.org/10.1016/j.tmaid.2020.101... ⁾⁾	13 and 18y	Family transmission and NS	No	No
Díaz et al.,⁽⁽¹³13 Díaz CA, Maestro ML, Pumarega MTM, Antón BF, Alonso CRP. Primer caso de infección neonatal por SARS-CoV-2 en España. An Pediatr. 2020;92(4):237-8. doi: 10.1016/j.anpedi.2020.03.002 https://doi.org/10.1016/j.anpedi.2020.03... ⁾⁾	8d	Community transmission	Prematurity	Yes/13
Chen et al.,⁽⁽¹⁴14 Chen C, Gao G, Xu Y, Pu L, Wang Q, Wang L, et al. SARS-CoV-2-Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19. Ann Intern Med. 2020;M20-0991. doi: 10.7326/M20-0991 https://doi.org/10.7326/M20-0991... ⁾⁾	2 - 10y	Community transmission	No	Yes/NS
Xiang et al.,⁽⁽¹⁵15 Xiang M, Liang S, Zhang Y, Zhang X, Gai Z, Zhang Z. Do children need a longer time to shed SARS-CoV-2 in stool than adults? J Microbiol, Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.010 https://doi.org/10.1016/j.jmii.2020.03.0... ⁾⁾	11m -9y	Family transmission	NS	Yes/NS
Peng e Zhang⁽⁽¹⁶16 Peng A, Zhang M. Novel coronavirus SARS-CoV-2: familial spread resulting in COVID-19 pneumonia in a pediatric patient. Diagn Interv Radiol. 2020;26(3):262-3. doi: 10.5152/dir.2020.20157 https://doi.org/10.5152/dir.2020.20157... ⁾⁾	03y	Family transmission	No	NS
Park et al.⁽⁽¹⁷17 Park JY, Han MS, Park KU, Kim JY, Choi EH. First Pediatric Case of Coronavirus Disease 2019 in Korea. J Korean Med Sci. 2020;35(11):e124. doi: 10.3346/jkms.2020.35.e124 https://doi.org/10.3346/jkms.2020.35.e12... ⁾⁾	10y	Family transmission	No	Yes/15
Lu et al.⁽⁽¹⁸18 Lu X, Zhang L, Du H, Zhang J, Li YY, Qu J, et al. SARS-CoV-2 Infection in Children. New England J Med. 2020;382(17):1663-5. doi: 10.1056/NEJMc2005073 https://doi.org/10.1056/NEJMc2005073... ⁾⁾	0 - 16y	Family transmission	Hydronephrosis and leukemia	NS
Ng et al.⁽⁽¹⁹19 Ng O-T, Marimuthu K, Chia P-Y, Koh V, Chiew CJ, De Wang L, et al. SARS-CoV-2 Infection among Travelers Returning from Wuhan, China. N Engl J Med. 2020;382(15):1476-8. doi: 10.1056/NEJMc2003100 https://doi.org/10.1056/NEJMc2003100... ⁾⁾	17y	Community transmission	No	No
Wang et al.⁽⁽²⁰20 Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020. doi: 10.1093/cid/ciaa225 https://doi.org/10.1093/cid/ciaa225... ⁾⁾	36h	Vertical transmission	No	Yes/18
Cao et al.⁽⁽²¹21 Cao Q, Chen Y-C, Chen C-L, Chiu C-H. SARS-CoV-2 infection in children: Transmission dynamics and clinical characteristics. J Formosan Med Assoc. 2020;119(3):670-3. doi: 10.1016/j.jfma.2020.02.009 https://doi.org/10.1016/j.jfma.2020.02.0... ⁾⁾	03m	Family transmission	No	Yes/15
Guan et al.⁽⁽²²22 Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382(18):1708-20. doi: 10.1056/NEJMoa2002032 https://doi.org/10.1056/NEJMoa2002032... ⁾⁾	0 - 15y	Community transmission	No	NS
Mansour et al.,⁽⁽²³23 Mansour A, Atoui R, Kanso K, Mohsen R, Fares Y, Fares J. First Case of an Infant with COVID-19 in the Middle East. Cureus. 2020. doi: 10.7759/cureus.7520 https://doi.org/10.7759/cureus.7520... ⁾⁾	16m	Family transmission	Infection for Streptococcus pneumoniae	Yes/NS
Pan et al.⁽⁽²⁴24 Pan X, Chen D, Xia Y, Wu X, Li T, Ou X, et al. Asymptomatic cases in a family cluster with SARS-CoV-2 infection. Lancet Infect Dis. 2020;20(4):410-1. doi: 10.1016/S1473-3099(20)30114-6 https://doi.org/10.1016/S1473-3099(20)30... ⁾⁾	03y	Family transmission	No	Yes/03
Sun et al.⁽⁽²⁵25 Sun D, Li H, Lu X-X, Xiao H, Ren J, Zhang F-R, et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study. World J Pediatr. 2020. doi: 10.1007/s12519-020-00354-4 https://doi.org/10.1007/s12519-020-00354... ⁾⁾	2m - 15y	Travel history and family transmission	NS	Yes/03 - 10
Xu et al.,⁽⁽²⁶26 Xu Y, Li X, Zhu B, Liang H, Fang C, Gong Y, et al. Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding. Nat Med. 2020;26(4):502-5. doi: 10.1038/s41591-020-0817-4 https://doi.org/10.1038/s41591-020-0817-... ⁾⁾	2 meses a 15 anos	Community transmission	NS	NS
Shi et al.,⁽⁽²⁷27 Shi Y, Wang X, Liu G, Zhu Q, Wang J, Yu H, et al. A quickly, effectively screening process of novel corona virus disease 2019 (COVID-19) in children in Shanghai, China. Ann Transl Med. 2020;8(5):241-241. doi: 10.21037/atm.2020.03.22 https://doi.org/10.21037/atm.2020.03.22... ⁾⁾	7m - 11y	Travel history and community transmission	NS	Yes/10
Su et al.,⁽⁽²⁸28 Su L, Ma X, Yu H, Zhang Z, Bian P, Han Y, et al. The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19. Emerg Micr Infect. 2020;9(1):707-13. doi: 10.1080/22221751.2020.1744483 https://doi.org/10.1080/22221751.2020.17... ⁾⁾	11m a 9y	Family transmission	NS	Yes/NS
Tan et al.,⁽⁽²⁹29 Tan Y, Tan B, Pan J, Wu J, Zeng S, Wei H. Epidemiologic and clinical characteristics of 10 children with coronavirus disease 2019 in Changsha, China. J Clin Virol. 2020;127:104353. doi: 10.1016/j.jcv.2020.104353 https://doi.org/10.1016/j.jcv.2020.10435... ⁾⁾	1 - 12y	Travel history and family transmission	NS	Yes/20
Xing et al.,⁽⁽³⁰30 Xing Y-H, Ni W, Wu Q, Li W-J, Li G-J, Wang W-D, et al. Prolonged viral shedding in feces of pediatric patients with coronavirus disease 2019. J Microbiol, Immunol Infect. 2020. doi: 10.1016/j.jmii.2020.03.021 https://doi.org/10.1016/j.jmii.2020.03.0... ⁾⁾	1 -6y	Family transmission	NS	Yes/NS
Yin et al.,⁽⁽³¹31 Yin X, Dong L, Zhang Y, Bian W, Li H. A mild type of childhood Covid-19: a case report. Radiol Infect Dis. 2020. doi: 10.1016/j.jrid.2020.03.004 https://doi.org/10.1016/j.jrid.2020.03.0... ⁾⁾	9y	NS	NS	Yes/NS
Chen et al.,⁽⁽³²32 Chen J, Zhang Z-Z, Chen Y-K, Long Q-X, Tian W-G, Deng H-J, et al. The clinical and immunological features of pediatric COVID-19 patients in China. Genes Dis. 2020. doi: 10.1016/j.gendis.2020.03.008 https://doi.org/10.1016/j.gendis.2020.03... ⁾⁾	7m - 17y	Travel history and community transmission	NS	Yes/NS
Morey-Olivé et al.,⁽⁽³³33 Morey-Olivé M, Espiau M, Mercadal-Hally M, Lera-Carballo E, García-Patos V. Manifestaciones cutáneas en contexto del brote actual de enfermedad por coronavirus 2019. An Pediatr. 2020. doi: 10.1016/j.anpedi.2020.04.013 https://doi.org/10.1016/j.anpedi.2020.04... ⁾⁾	2m e 6y	Community transmission	Cholestatic liver disease	Yes/NS
Liu et al.,⁽⁽³⁴34 Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: focus on pregnant women and children. J Infect. 2020;80(5):e7-13. doi: 10.1016/j.jinf.2020.03.007 https://doi.org/10.1016/j.jinf.2020.03.0... ⁾⁾	11m - 9y	Community transmission	NS	NS
Chacón-Aguilar et al.,⁽⁽³⁵35 Chacón-Aguilar R, Osorio-Cámara JM, Sanjurjo-Jimenez I, González-González C, López-Carnero J, Agapito BP-M-. COVID 19: sindrome febril y clínica neurólogica en neonato. An Pediatr. 2020. doi: 10.1016/j.anpedi.2020.04.012 https://doi.org/10.1016/j.anpedi.2020.04... ⁾⁾	26d	NS	NS	Yes/06
Ji et al.,⁽⁽³⁶36 Ji L-N, Chao S, Wang Y-J, Li X-J, Mu X-D, Lin M-G, et al. Clinical features of pediatric patients with COVID-19: a report of two family cluster cases. World J Pediatr. 2020. doi: 10.1007/s12519-020-00356-2 https://doi.org/10.1007/s12519-020-00356... ⁾⁾	9 e 15y	Travel history	No	Yes/02
Cai et al.,⁽⁽³⁷37 Cai J, Xu J, Lin D, Yang Z, Xu L, Qu Z, et al. A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features. Clin Infect Dis. 2020;ciaa198. doi: 10.1093/cid/ciaa198 https://doi.org/10.1093/cid/ciaa198... ⁾⁾	3m - 10y	Family and community transmission	NS	Yes/NS
Dong et al.,⁽⁽³⁸38 Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020. doi: 10.1542/peds.2020-0702 https://doi.org/10.1542/peds.2020-0702... ⁾⁾	2 -13y	Community transmission	NS	Yes/NS
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Zhu et al.,⁽⁽⁴⁰40 Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, et al. Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 2020;9(1):51-60. doi: 10.21037/tp.2020.02.06 https://doi.org/10.21037/tp.2020.02.06... ⁾⁾	1 - 9d	Community transmission	Alteration of liver function	Yes/NS
Wei, et al.,⁽⁽⁴¹41 Wei M, Yuan J, Liu Y, Fu T, Yu X, Zhang Z-J. Novel coronavirus infection in hospitalized infants under 1 year of age in China. JAMA. 2020;323(13):1313. doi: 10.1001/jama.2020.2131 https://doi.org/10.1001/jama.2020.2131... ⁾⁾	28d - 1y	Family transmission	NS	NS

[1] Corresponding author: Fabiane Blanco Silva Bernardino E-mail: fabianeblanco25@gmail.com

Brasil

Brasil

Perfil epidemiológico de niños y adolescentes con COVID-19: revisión del alcance

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