Factors associated with extubation failure in an intensive care unit: a case-control study

Abstract

Objective:

to investigate the factors associated with extubation failure of patients in the intensive care unit.

Method:

unpaired, longitudinal, retrospective and quantitative case-control with the participation of 480 patients through clinical parameters for ventilator weaning. Data were analyzed by: Fisher’s exact test or the chi-square test; unpaired two-tailed Student’s t test; and Mann-Whitney test. Significant P values lower than or equal to 0.05 were admitted.

Results:

of the patients, 415 (86.5%) were successful and 65 (13.5%) failed. Success group: the most negative fluid balance, APACHE II in 20 (14-25), weak cough in 58 (13.9%). Failure group: the most positive fluid balance, APACHE II in 23 (19-29), weak cough in 31 (47.7%), abundant amount of pulmonary secretions in 47.7%.

Conclusion:

positive fluid balance and the presence of inefficient cough or inability to clear the airway were predictors of extubation failure.

Descriptors:
Patient; Extubation; Risk Factors; Treatment Failure; Artificial Respiration; Intensive Care Unit