@article{ribeiro_giordano_2005,  title={Variational calculus (optimal control) applied to the optimization of the enzymatic synthesis of ampicillin},  volume={48},  ISSN={1516-8913},  url={https://doi.org/10.1590/S1516-89132005000400003},  DOI={10.1590/S1516-89132005000400003},  number={spe},  journal={Brazilian Archives of Biology and Technology},  publisher={Instituto de Tecnologia do Paraná - Tecpar},  author={Ribeiro, Marcelo Perencin de Arruda and Giordano, Roberto de Campos},  year={2005},  month={Jun},  pages={19–28} }