Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine <i>versus</i> other treatments: a systematic review and meta-analysis of randomized controlled trials

Maciel, Alex Bezerra da Silva; Ortiz, Josmar França; Siqueira, Beatriz Santos; Zanette, Gabriela Ferreira

doi:10.1590/abd1806-4841.20198321

Alex Bezerra da Silva Maciel Mailing address: Alex Bezerra da Silva Maciel. E-mail: alexmaciellive@hotmail.com

Graduate Studies Program in Tropical Medicine, Universidade do Estado do Amazonas, Manaus (AM), Brazil

https://orcid.org/0000-0002-9836-7868

Josmar França Ortiz

Graduate Studies Program in Cardiology and Hemodynamics, Faculdade Metropolitana de Manaus, Manaus (AM), Brazil

https://orcid.org/0000-0002-4160-915X

Beatriz Santos Siqueira

Undergraduate student in Pharmacy, Universidade Federal do Amazonas, Manaus (AM), Brazil

https://orcid.org/0000-0002-9155-2251

Gabriela Ferreira Zanette

Graduate Studies Program in Biotechnology, Universidade Federal do Amazonas, Manaus (AM), Brazil

https://orcid.org/0000-0001-8043-7920

Mailing address: Alex Bezerra da Silva Maciel. E-mail: alexmaciellive@hotmail.com

Conflict of interest: None.

AUTHORS'CONTRIBUTIONS

Alex Bezerra da Silva Maciel

0000-0002-9836-7868

Statistical analysis; Conception and planning of the study; Elaboration and writing of the manuscript; Obtaining, analyzing, and interpreting the data

Josmar França Ortiz

0000-0002-4160-915X

Approval of the final version of the manuscript; Critical review of the literature

Beatriz Santos Siqueira

0000-0002-9155-2251

Approval of the final version of the manuscript; Conception and planning of the study; Elaboration and writing of the manuscript; Obtaining, analyzing and interpreting the data; Effective participation in research orientation; Intellectual participation in propaedeutic and/or therapeutic conduct of the cases studied; Critical review of the literature; Critical review of the manuscript

Gabriela Ferreira Zanette

0000-0001-8043-7920

Effective participation in research orientation; Intellectual participation in propaedeutic and/or therapeutic management of cases; Critical review of the manuscript

Study	Study Type (n) Patients	Intervention	Follow-up time	Follow-up time	Jadad Scale
Genuíno, 2014⁷7 Genuino GA, Baluyut-Angeles KV, Espiritu AP, Lapitan MC, Buckley BS. Topical petrolatum gel alone versus topical silver sulfadiazine with standard gauze dressings for the treatment of superficial partial thickness burns in adults: A randomized controlled trial. Burns. 2014;40:1267-73.	Randomized Clinical Trial (n = 50)	Experimental: Petrolatum gel Control: SSD	Until the end	GE: 6.2 ± (SD 2.8) GC: 7.8 ± (SD 2.1) (p = 0.050)	3
Saeidinia, 2017⁸8 Saeidinia A, Keihanian F, Lashkari AP, Lahiji HG, Mobayyen M, Heidarzade A, et al. Partial-thickness burn wounds healing by topical treatment: a randomized controlled comparison between silver sulfadiazine and Centiderm. Medicine (Baltimore). 2017;96:e6168.	Randomized Clinical Trial (n = 75)	Experimental: Centiderm Control: SSD	25 days	GE: 14.67± (SD 1.78) CG: 21.53 ± (SD 1.65) (P = 0.001)	5
Shahzad, 2013⁹9 Shahzad MN, Ahmed N. Effectiveness of Aloe Vera Gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns. J Pak Med Assoc. 2013;63:225-30.	Randomized Clinical Trial (n = 50)	Experimental: Aloe vera Gel Control: SSD	60 days	GE: 11 ± (SD 4.18) CG: 24.24 ± (SD 11.16) (p = < 0.0001)	1
Nasiri, 2016¹⁰10 Nasiri E, Hosseinimehr SJ, Zaghi Hosseinzadeh A, Azadbakht M, Akbari J, Azadbakht M. The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial. J Ethnopharmacol. 2016;189:107-16.	Randomized Clinical Trial (n = 90)	Experimental: Arnebia euchroma ointment Control: SSD	30 days	GE: 13.9 ± (SD 5.3) GC: 17.5 ± (SD 6.9) (p = 0.001)	4
Muangman, 2010¹¹11 Muangman P, Pundee C, Opasanon S, Muangman S. A prospective, randomized trial of silver containing hydrofibra dressing versus 1% silver sulfadiazine for the treatment of partial thickness burns. Int Wound J. 2010;7:271-6.	Randomized Clinical Trial (n = 70)	Experimental: Aquacel^® Ag dressing Control SSD	35 days	GE: 10 ± (SD 3.0) GC: 13.7 ± (SD 4.3) (p = 0.02)	2
Malik, 2010¹²12 Malik KI, Malik MA, Aslam A. Honey compared with silver sulphadiazine in partial-thickness burns. Int Wound J. 2010;7:413-7.	Randomized Clinical Trial (n = 150)	Experimental: Honey Control SSD	Until the end	GE: 13.47 ± (SD 4.0) GC: 15.62 ± (SD 4.40) (p < 0.0001)	1
Homann, 2007¹³13 Homann HH, Rosbach O, Moll W, Vogt PM, Germann G, Hopp M, et al. A Liposome Hydrogel with Polyvinyl-Pyrrolidone Iodine in the Local Treatment of Partial-Thickness Burn Wounds. Ann Plast Surg. 2007;59:423-7.	Randomized Clinical Trial (n = 47)	Experimental: Liposome Hydrogel with Polyvinyl-Pyrrolidone Iodine Control: SSD	Until the end	GE: 9.9 ± (SD 4.5) GC: 11.3 ± (SD 4.9) (p = 0.015)	2
Huang, 2007¹⁴14 Huang Y, Li X, Liao Z, Zhang G, Liu Q, Tang J, et al. A randomized comparative trial between Acticoat and SD-Ag in the treatment of residual burn wounds, including safety analysis. Burns. 2007;33:161-6.	Randomized Clinical Trial (n = 98)	Experimental: Acticoat Control: SSD	20 days	GE: 12.42 ± (SD 5.40) GC: 15.79 ± (SD 5.60) (p = 0.005)	3
Aramwit, 2013¹⁵15 Aramwit P, Palapinyo S, Srichana T, Chottanapund S, Muangman P. Silk sericin ameliorates wound healing and its clinical efficacy in burn wounds. Arch Dermatol Res. 2013;305:585-94.	Randomized Clinical Trial (n = 29)	Experimental: Sulfadiazine Silk Sericin Control: SSD	Until the end	GE: 22.42 ± (SD 6.33) GC: 29.28 ± (SD 9.27) (p = 0.001)	5
Maghsoudi, 2013¹⁶16 Maghsoudi H, Nezami N, Mirzajanzadeh M. Enhancement of burn wounds healing by platelet dressing. Int J Burns Trauma. 2013;3:96-101.	Randomized Clinical Trial (n = 50)	Experimental: Platelet Healing Control: SSD	Until the end	GE: 9.5 ± (SD 4.6) GC: 12.2 ± (SD 5.4) (p < 0,0001)	3
Wattanaploy,2017¹⁷17 Wattanaploy S, Chinaroonchai K, Namviriyachote N, Muangman P. Randomized Controlled Trial of Polyhexanide/Betaine Gel Versus Silver Sulfadiazine for Partial Thickness Burn Treatment. Int J Low Extrem Wounds. 2017;16:45-50.	Randomized Clinical Trial (n = 46)	Experimental: Polyhexanide/ Betaine Gel Control: SSD	22 days	GE: 17.8 ± (SD 2.2) GC: 18.8 ± (SD 2.1) (p=0.13)	2

[1] Mailing address: Alex Bezerra da Silva Maciel. E-mail: alexmaciellive@hotmail.com

Brasil

Brasil

Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials^* * Work conducted at Universidade do Estado do Amazonas, Manaus (AM), Brazil.

Abstract

Brasil

Brasil

Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials* * Work conducted at Universidade do Estado do Amazonas, Manaus (AM), Brazil.

Abstract

Tissue healing efficacy in burn patients treated with 1% silver sulfadiazine versus other treatments: a systematic review and meta-analysis of randomized controlled trials^* * Work conducted at Universidade do Estado do Amazonas, Manaus (AM), Brazil.