Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis

Kurizky, Patricia Shu; Martins, Gladys Aires; Carneiro, Jamille Nascimento; Gomes, Ciro Martins; Mota, Licia Maria Henrique da

doi:10.1590/abd1806-4841.20183071

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Investigation • An. Bras. Dermatol. 93 (6) • Nov/Dec 2018 • https://doi.org/10.1590/abd1806-4841.20183071 copy

Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis^* * Work conducted at Hospital Universitário de Brasília, Universidade de Brasília, Brasília (DF), Brazil.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract:

Background:

Psoriasis has a significant impact on quality of life (QoL). Sexual life can also be affected, with sexual dysfunction being reported by 25-70% of patients.

Objectives:

To determine the occurrence of sexual dysfunction and evaluate QoL in women with psoriasis.

Methods:

This case-control study included women aged 18-69 years. The validated Brazilian Portuguese versions of the Female Sexual Function Index (FSFI) and of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) were administered to all participants to assess sexual function and QoL, respectively. Patients with psoriasis underwent clinical evaluation for the presence of comorbidities, especially psoriatic arthritis and other rheumatic manifestations. Location of lesions and the extent of skin involvement were also assessed.

Results:

The sample consisted of 150 women, 75 with diagnosis of psoriasis and 75 healthy controls. Prevalence of sexual dysfunction was high in women with psoriasis (58.6% of the sample). Prevalence was statistically higher in women with psoriasis than in controls (P = 0.014). The SF-36 domain scores were also lower in women with psoriasis, with role limitations due to physical health, limitations due to emotional problems, and mental health being the most affected domains.

Study limitations:

Sample size was calculated to evaluate the association between the occurrence of sexual dysfunction and psoriasis, but it did not include the determination of the possible causes of this dysfunction.

Conclusions:

QoL and sexual function were altered in women with psoriasis and should be taken into consideration when assessing disease severity.

Keywords:
Arthritis, Psoriatic; Psoriasis; Quality of life; Sexual dysfunction, physiological

	Psoriasis group
Extent of psoriasis (PASI)	0-21.4 (Median 3.6)
Clinical type of psoriasis
Psoriasis vulgaris	69 (92%)
Palmoplantar psoriasis	4 (5.3%)
Guttate psoriasis	1 (1.3%)
Erythrodermic psoriasis	1 (1.3%)
Ungual involvement
Present	25 (33.3%)
Absent	50 (66.6%)
Genital involvement
Present	15 (20%)
Absent	55 (73.3%)
Missing data	5 (6.7%)
Involvement of exposed areas*
Present	23 (30.7%)
Absent	48 (64%)
Missing data	4 (5.3%)
Associated rheumatologic diagnosis
Fibromyalgia	16 (21.3%)
Psoriatic arthritis	10 (13.3%)
Osteoarthritis	2 (2.6%)
Others	10 (13.3%)
Absence of rheumatologic alterations	31 (41.3%)
Missing data	6 (8%)

	Psoriasis group	Control group		p-value
Presence of comorbidity	54 (72%)	34 (45.3%)	88 (65.10%)	0.023
SAH	18 (24%)	14 (18.6%)		0.43
DM	14 (18.6%)	8 (10.7%)		0.17
Dyslipidemia	16 (21.3%)	7 (9.3%)		0.042
Absence of comorbidity	19 (25.3%)	28 (37.3%)	47 (34.81%)
Missing data	2 (2.6%)	13 (17.3%)

		Mean	Standard deviation	p-value^* * Adjusted for age, schooling, marital status, and ethnicity * significance: p-value < 0.05
PHYSICAL FUNCTIONING - SF36	Control	80.3	20.0	0.641
	Patient	78.7	24.5
ROLE PHYSICAL - SF36	Control	72.3	39.1	0.002
	Patient	45.0	47.2
BODILY PAIN - SF36	Control	63.8	24.4	0.503
	Patient	62.3	29.6
GENERAL HEALTH - SF36	Control	70.3	19.9	0.169
	Patient	62.8	27.3
VITALITY - SF36	Control	61.3	19.0	0.081
	Patient	55.7	28.5
SOCIAL FUNCTIONING - SF36	Control	75.3	21.0	0.191
	Patient	69.2	32.3
ROLE EMOTIONAL - SF36	Control	67.6	39.0	0.029
	Patient	47.6	47.8
MENTAL HEALTH - SF36	Control	69.3	16.5	0.021
	Patient	59.6	28.0

		Mean	Standard deviation	p-value^* * Results adjusted for age, race, schooling, and marital status * significance: p-value <0.05
DESIRE	Control	3.6	1.2	0.019
	Patient	3.2	1.3
AROUSAL	Control	3.9	1.8	0.001
	Patient	2.6	2.2
LUBRICATION	Control	4.3	1.9	0.014
	Patient	3.1	2.6
ORGASM	Control	4.2	1.8	0.017
	Patient	3.1	2.7
SATISFACTION	Control	4.6	2.0	0.001
	Patient	3.1	2.6
PAIN	Control	4.5	2.0	0.012
	Patient	3.4	2.7

Sociedade Brasileira de Dermatologia Av. Rio Branco, 39 18. and., 20090-003 Rio de Janeiro RJ, Tel./Fax: +55 21 2253-6747 - Rio de Janeiro - RJ - Brazil
E-mail: revista@sbd.org.br

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[1] Mailing Address: Patricia Shu Kurizky. E-mail: patyshu79@gmail.com

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Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis* * Work conducted at Hospital Universitário de Brasília, Universidade de Brasília, Brasília (DF), Brazil.

Abstract:

Background:

Objectives:

Methods:

Results:

Study limitations:

Conclusions:

Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis^* * Work conducted at Hospital Universitário de Brasília, Universidade de Brasília, Brasília (DF), Brazil.