We report the case of three boys with prepubertal gynecomastia, of uncommon etiology. In the first case, bilateral gynecomastia began at the age of 5 years and 10 months and was associated with nutritional disturbance secundary to celiac disease. In the second case, unilateral gynecomastia was detected at the age of 8 years and 5 months after the introduction of a GnRH analogue for treatment of idiopathic true precocius puberty diagnosed at 5 years of age. In the third case, bilateral gynecomastia began at the age of 5 years and 9 months and was associated to estrogenic contaminant of non-identified source. In all of the cases, the clinical evolution was unremarkable with regression of the gynecomastia. The presentation of the cases confirms that gynecomastia in this age, although rare, frequently presents diagnostic difficulties in relation to the trigger off process.
Gynecomastia; Prepubertal gynecomastia; Refeeding gynecomastia; GnRH analogue