Basics aspects of the ischemia reperfusion injury and of the ischemic preconditioning

Abstract

Ischemia contributes to the pathogenesis of many perioperative clinical conditions. Although restoration of blood flow to an ischemic organ is essencial to prevent irreversible cellular injury, reperfusion may augment tissue injury in excess to that produced by ischemia alone. Thus, cellular damage after reperfusion of previously viable ischemic tissue is defined as ischemia-reperfusion injury. The basic aspects of I/R are reviewed.

ischemia; reperfusion; ischemia-reperfusion; liver