Ângulo de fase como preditor de massa muscular em pacientes com doença inflamatória intestinal

BONGIOLO, Angela Martinha; MACHADO, Marcos José; LAZAROTTO, Bruno Ayala; RUPP, Maria Luiza Cimardi; DAL-PIZZOL, Felipe; PIRES, Maria Marlene de Souza

Angela Martinha BONGIOLO

designed the research

collected the clinical data

analyzed the data

wrote the paper

Universidade Federal de Santa Catarina, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, SC, Brasil.

https://orcid.org/0000-0002-5675-7876

Marcos José MACHADO

analyzed the data

wrote the paper

Universidade Federal de Santa Catarina, Departamento de Análises Clínicas, Florianópolis, SC, Brasil.

https://orcid.org/0000-0002-7010-5153

Bruno Ayala LAZAROTTO

collected the clinical data

Universidade Federal de Santa Catarina, Faculdade de Medicina, Florianópolis, SC, Brasil.

https://orcid.org/0009-0002-0336-526X

Maria Luiza Cimardi RUPP

collected the clinical data

Universidade Federal de Santa Catarina, Faculdade de Medicina, Florianópolis, SC, Brasil.

https://orcid.org/0009-0009-8390-6900

Felipe DAL-PIZZOL

designed the research

analyzed the data

reviewed the manuscript

Universidade do Extremo Sul Catarinense, Programa de Pós-Graduação em Ciências da Saúde, Laboratório de Fisiopatologia Experimental, Unidade de Ciências da Saúde, Criciúma, SC, Brasil.

https://orcid.org/0000-0003-3003-8977

Maria Marlene de Souza PIRES

designed the research

analyzed the data

wrote the paper

reviewed the manuscript

Universidade Federal de Santa Catarina, Divisão de Pediatria, Florianópolis, SC, Brasil.

https://orcid.org/0000-0001-5502-7436

Corresponding author: Angela Martinha Bongiolo. E-mail: nutangela@hotmail.com

Declared conflict of interest of all authors: none

Variable	Disease activity						P*
	Remission		Mild		Moderate/severe
	Female	Male	Female	Male	Female	Male
Age	48.5	39.5	40	32	46.5	32	0.027
	(35.0-59.0)	(27.0-46.5)	(29.2-45.7)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.	(21.5-47.0)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.	(34.0-63.0)	(29.2-37.7)
SMM	17.0	23.3	16.6(15.5-	20.1	14.8	18.7	<0.001
	(15.3-18.4)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92. 5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(21.7-24.9)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	18.8)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92. 5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(19.7-24.1)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(13.2-16.2)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9. 2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^-³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(16.8-25.85)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9. 2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^-³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.
SMI	6.6	7.7	6.5	7.3	5.7	6.7	<0.001
	(6.2-7.1)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^-⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(7.1-8.3)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(5.4-7.6)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(6.6-7.9)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(5.3-6.3)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9. 2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22. 3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^-⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(6.3-8.5)⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.
HGS	25.5	50	24	44	21	24	<0.001
	(210-30.0)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(41.0-54.0)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(20.5-31.0)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^-⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(37.5-50.2)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(18.0-24.0)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9. 2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22. 3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^-⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(18.5-41.2)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^-⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.
%BF	36.2	25.1	30.9	19.5	30.4	13.6	<0.001
	(30.9-39.9)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22. 3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^-⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(19.7-28.3)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(28.7-34.8)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^-²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(17.1-25.4)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(27.6-34.8)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(11.2-18.9)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.
BMI	27.8	25.8	24.7	22.9	23.1	20.5	0.034
	(23.4-31.6)⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(23.0-28.0)	(21.9-29.8)	(19.9-28.2)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.	(20.1-29.9)	(18.1-24.9)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.
R	598	529	589	556	646.5	554	<0.001
	(553-659)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(475-578.5)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(507.5-715.5)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(487-602)⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(588-706)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(455.5-595.5)⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.
Xc	61	54	64	59	50	64	0.277
	(52-73)	(46.5-64.0)	(50.7-72.5)	(49.2-63.5)	(46.0-65.0)	(41.2-69.5)
PhA	6.0	6.1	6.0	6.1	5.02	8.0	0.277
	(5.0-6.1)	(4.9-7.0)	(4.9-7.7)	(4.9-7.0)	(4.0-5.1)	(4.0-8.0)
Alb (g/L)	4.1	4.3	3.8	3.7	3.4	3.3	<0.001
	(3.8-4.3)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(4.0-4.6)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92. 5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(3.5-4.1)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(2.5-4.3)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(3.1-3.7)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(2.8-3.5)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.
Hb (g/L)	12.9	14.6	12.6	14.2	11.3	11.4	<0.001
	(12.2-13.6)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(13.8-15.3)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656. 4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92. 5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(12.1-13.8)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(11.9-16.2)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(9.5-13.2)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.	(10.9-13.4)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^,⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92.
CRP (mg/L)	4	2.5	5.5	5.8	21.3	20.6	<0.001
	(1.3-6.0)⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^,⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(0.8-6.0)⁴4. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, et al. Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017;36:1586-92. 5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.^-⁶6. Bryant RV., Trott MJ, Bartholomeusz FD, Andrews JM. Systematic review: Body composition in adults with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:213-25.	(1.4-15.8)⁵5. Li S, Ney M, Eslamparast T, Vandermeer B, Ismond KP, Kroeker K, et al. Systematic review of nutrition screening and assessment in inflammatory bowel disease. World J Gastroenterol . 2019;25:3823-37.	(3.0-29.3)²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.	(10.0-32.5)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9. 2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.^-³3. Dhaliwal A, Quinlan JI, Overthrow K, Greig C, Lord JM, Armstrong MJ, et al. Sarcopenia in inflammatory bowel disease: A narrative overview. Nutrients. 2021;13:656.	(4.6-43.0)¹1. Zhang YZ, Li YY. Inflammatory bowel disease: Pathogenesis. World J Gastroenterol. 2014;20:91-9.^,²2. Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease J Med Life. 2019;12:113-22.

n (disease activity)	All		Female		Male
	n=145 (remission, mild, moderate or severe)		n=85 (remission, mild, moderate or severe)		n=58 (remission, mild, moderate or severe)
Variables	r_S	P*	r_S	P*	r_S	P*
Age	-0.247	0.0027	-0.192	0.0741	-0.216	0.1028
SMM	0.35	<0.0001	0.326	0.0021	0.487	0.0001
SMI	0.427	<0.0001	0.38	0.0003	0.432	0.0007
HGS	0.127	0.1291	0.071	0.5143	0.12	0.3692
%BF	-0.058	0.4895	0.171	0.1126	-0.17	0.2018
BMI	0.113	0.1755	0.179	0.0976	0.063	0.6363
R	-0.114	0.1739	0.058	0.5961	-0.181	0.1732
Xc	0.781	<0.0001	0.832	<0.0001	0.835	<0.0001
Alb(g/L)	0.096	0.3707	0.065	0.6523	0.01	0.9542
Hb (g/L)	0.126	0.1436	0.118	0.2885	-0.074	0.5996
CRP (mg/L)	0.038	0.6785	0.075	0.5332	0.028	0.85

n (disease activity)	All		Female		Male
	n=39 (mild, moderate and/or severe)		n=25 (moderate and/or severe)		n 14 (severe)
Variables	r_S	P*	r_S	P*	r_S	P*
Age	-0.121	0.4644	-0.276	0.1821	0.245	0.3985
SMM	0.553	0.0003	0.566	0.0032	0.596	0.0246
SMI	0.651	<0.0001	0.598	0.0016	0.635	0.0147
HGS	0.075	0.6504	0.064	0.7616	0.132	0.6528
%BF	-0.0051	0.7587	0.136	0.5175	0.011	0.9703
BMI	0.266	0.1022	0.417	0.0383	0.143	0.6261
R	-0.379	0.0172	-0.287	0.1636	-0.336	0.2398
Xc	0.725	<0.0001	0.739	<0.0001	0.744	0.0023
Alb(g/L)	0.423	0.0908	0.706	0.0226	0.357	0.4316
Hb (g/L)	0.238	0.1498	0.199	0.3505	0.27	0.3499
CRP (mg/L)	-0.231	0.2027	-0.084	0.7241	-0.364	0.2453

Variable	OR	CI95%	P	ORa*	CI95%	P
Sex (men)	1.6905	0.7664 to 3.7287	0.1933	1.1287	0.4427 to 2.8775	0.7998
Age (1º quartil)	0.2845	0.09568 to 0.8459	0.0238	0.2541	0.0722 to 0.8946	0.0329
Age (2º quartil)	0.275	0.09267 to 0.8160	0.0200	0.1462	0.0408 to 0.5231	0.0031
Age (3º quartil)	0.1719	0.05060 to 0.5838	0.0048	0.0965	0.0241 to 0.3869	0.001
Categorized PhA for muscle mass reduction	7.8652	2.8209 to 21.9300	0.0001	12.115	3.8422 to 38.2005	<0.0001

[1] Corresponding author: Angela Martinha Bongiolo. E-mail: nutangela@hotmail.com

Brasil

Brasil

Ângulo de fase como preditor de massa muscular em pacientes com doença inflamatória intestinal

RESUMO

Objetivo:

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