Novas observações sôbre as fibras nervosas que repopulam o segmento distal de nervos com mais de seis meses de secção completa

Erhart, Eros Abrantes; Rezze, Cecil José

doi:10.1590/S0004-282X1966000200002

Resumos

Com base em dados experimentais, publicados em trabalhos anteriores, são apresentados e discutidos, aspectos histológicos que, analisados em seqüência (figs. 1 a 8), sugerem uma possível via de reorganização progressiva com conseqüente regeneração de fibras nervosas, nos segmentos intermédio e distal de nervos, completamente separados por transecção, entre si e do côto proximal, há mais de seis meses, mas mantidos em seus leitos conectivos naturais.

Based on experimental data previously published is presented and discussed a progressive sequence of histological findings (figs. 1-8) which suggest a possible gradual reorganization and regeneration of nerve-fibres in the distal and intermediate nerve segments, completely separated from the proximal stump for more than six months, but maintained undisturbed in their natural connective tissues beds.

Further discussion on the "new-growing" nerve-fibres which repopulate the distal segment of nerves completely separated from the proximal stump for more than six months

Novas observações sôbre as fibras nervosas que repopulam o segmento distal de nervos com mais de seis meses de secção completa

Eros Abrantes Erhart^I; Cecil José Rezze^II

^IProfessor Assistente, Docente-Livre, Chefe da Secção de Neuranatomia; Departamento de Anatomia da Faculdade de Medicina da Universidade de São Paulo (Prof. O. Machado de Sousa)

^IIProfessor Assistente; Departamento de Anatomia da Faculdade de Medicina da Universidade de São Paulo (Prof. O. Machado de Sousa)

ABSTRACT

Based on experimental data previously published is presented and discussed a progressive sequence of histological findings (figs. 1-8) which suggest a possible gradual reorganization and regeneration of nerve-fibres in the distal and intermediate nerve segments, completely separated from the proximal stump for more than six months, but maintained undisturbed in their natural connective tissues beds.

ABSTRACT

Com base em dados experimentais, publicados em trabalhos anteriores, são apresentados e discutidos, aspectos histológicos que, analisados em seqüência (figs. 1 a 8), sugerem uma possível via de reorganização progressiva com conseqüente regeneração de fibras nervosas, nos segmentos intermédio e distal de nervos, completamente separados por transecção, entre si e do côto proximal, há mais de seis meses, mas mantidos em seus leitos conectivos naturais.

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Departamento de Anatomia. Faculdade de Medicina da Universidade de São Paulo - Caixa Postal 2921 - São Paulo, SP - Brasil

1. CAJAL, S. RAMON y - Degeneration and regeneration of the nervous system. Translated and edited by Raoul M. May. Oxford Univ. Press, London, 1928.
2. COURTEY, B. - Observations en contraste de phase de la régéneration "per primam intentionem" des fibres nerveuses en culture chez l'embryon de poulet. Comptes Rendus de l'Ass. Anat. 117:458-473, 1963.
3. DAHLSTRÖM, A. - Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression. J. Anat. 99:677-689, 1965.
4. DE ROBERTIS, E. - Histophysiology of Synapses and Neurosecretion. Pergamon Press, Oxford-London-New York-Paris, 1964.
5. DROZ, B. & LEBLOND, C. P. - Axonal migration of proteins in the central nervous system and peripheral nerves as shown by autoradiography. J. Comp. Neurol. 121:325-346, 1963.
6. ERHART, M. B. & ERHART, E. A. - Sôbre o comportamento das fibras nervosas no côto distal de nervo fibular de Canis familiaris após transecção total. Folia Clinica et Biológica (São Paulo) 28:98, 1958.
7. ERHART, E. A. & ERHART, M. B. - Normal axis-cylinders in the distal segment of nerves completely separated from the proximal stump for up to 24 years. Anat. Rec. 136:189, 1960.
8. ERHART, E. A. - Normal nerve-fibres !n the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-psiquiat. (São Paulo) 20:289-306, 1962.
9. ERHART, E. A. & REZZE, C. J. - Nerve fibres in isolated segments of dog ulnar nerve after complete brachial plexotomy and periaxilar artery sympathectomy. Arq. Neuro-siquit. (São Paulo) 23:82-90, 1965.
10. ERHART, E. A. & REZZE, C. J. - The neuroma-like structure of the long-time severed and isolated nerve stumps. Arq. Neuro-psiquiat. (São Paulo) 23:91-94, 1965.
11. ERHART, E. A. & REZZE, C. J. - Experimental data and practical results which modify the present concepts of peripheral nerve fibres degeneration and regeneration. Proceedings of the V International Congress of Neuropathology: 667-671, 1965. Published by Excerpta Medica.
12. HYDÉN, H. - The Neuron. In The Cell, IV, 215-323. Edited by Brachet and Mirsky. Academic Press. New York-London, 1960.
13. LEVI-MONTALCINI, R. - Growth control of nerve cells by a protein factor and its antiserum. Science 143:105-110, 1964.
14. LUBINSKA, L. et al. - Bidirectional movements of axoplasm in peripheral nerve fibres. Acta Biol. Exp. Var. 23:239-247, 1963. (Quoted from Dahlström³).
15. PINNER, B. & CAMPBELL, J. B. - Alkaline phosphatase activity of incisures and nodes during degeneration and regeneration of peripheral nerve fibres. Exp. Neurol. 12:159-172, 1965.
16. SHANTHAVEERAPPA, T. R. & BOURNE, G. H. - The effects of transection of the nerve trunk on the perineural epithelium with special reference to its role in nerve degeneration and regeneration. Anat. Rec. 150:35-50, 1964.
17. WEISS, P.; TAYLOR, A. C. & PILLAI, P. A. - The nerve fibres as a system in continuous flow: microcinematographic and electron microscopic demonstrations. Science 136:330, 1962.

Datas de Publicação

Publicação nesta coleção
14 Ago 2013
Data do Fascículo
Jun 1966

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. CAJAL, S. RAMON y - Degeneration and regeneration of the nervous system. Translated and edited by Raoul M. May. Oxford Univ. Press, London, 1928.

[2] 2. COURTEY, B. - Observations en contraste de phase de la régéneration "per primam intentionem" des fibres nerveuses en culture chez l'embryon de poulet. Comptes Rendus de l'Ass. Anat. 117:458-473, 1963.

[3] 3. DAHLSTRÖM, A. - Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression. J. Anat. 99:677-689, 1965.

[4] 4. DE ROBERTIS, E. - Histophysiology of Synapses and Neurosecretion. Pergamon Press, Oxford-London-New York-Paris, 1964.

[5] 5. DROZ, B. & LEBLOND, C. P. - Axonal migration of proteins in the central nervous system and peripheral nerves as shown by autoradiography. J. Comp. Neurol. 121:325-346, 1963.

[6] 6. ERHART, M. B. & ERHART, E. A. - Sôbre o comportamento das fibras nervosas no côto distal de nervo fibular de Canis familiaris após transecção total. Folia Clinica et Biológica (São Paulo) 28:98, 1958.

[7] 7. ERHART, E. A. & ERHART, M. B. - Normal axis-cylinders in the distal segment of nerves completely separated from the proximal stump for up to 24 years. Anat. Rec. 136:189, 1960.

[8] 8. ERHART, E. A. - Normal nerve-fibres !n the distal segment of nerves completely separated from the proximal stump for more than six months. Arq. Neuro-psiquiat. (São Paulo) 20:289-306, 1962.

[9] 9. ERHART, E. A. & REZZE, C. J. - Nerve fibres in isolated segments of dog ulnar nerve after complete brachial plexotomy and periaxilar artery sympathectomy. Arq. Neuro-siquit. (São Paulo) 23:82-90, 1965.

[10] 10. ERHART, E. A. & REZZE, C. J. - The neuroma-like structure of the long-time severed and isolated nerve stumps. Arq. Neuro-psiquiat. (São Paulo) 23:91-94, 1965.

[11] 11. ERHART, E. A. & REZZE, C. J. - Experimental data and practical results which modify the present concepts of peripheral nerve fibres degeneration and regeneration. Proceedings of the V International Congress of Neuropathology: 667-671, 1965. Published by Excerpta Medica.

[12] 12. HYDÉN, H. - The Neuron. In The Cell, IV, 215-323. Edited by Brachet and Mirsky. Academic Press. New York-London, 1960.

[13] 13. LEVI-MONTALCINI, R. - Growth control of nerve cells by a protein factor and its antiserum. Science 143:105-110, 1964.

[14] 14. LUBINSKA, L. et al. - Bidirectional movements of axoplasm in peripheral nerve fibres. Acta Biol. Exp. Var. 23:239-247, 1963. (Quoted from Dahlström³).

[15] 15. PINNER, B. & CAMPBELL, J. B. - Alkaline phosphatase activity of incisures and nodes during degeneration and regeneration of peripheral nerve fibres. Exp. Neurol. 12:159-172, 1965.

[16] 16. SHANTHAVEERAPPA, T. R. & BOURNE, G. H. - The effects of transection of the nerve trunk on the perineural epithelium with special reference to its role in nerve degeneration and regeneration. Anat. Rec. 150:35-50, 1964.

[17] 17. WEISS, P.; TAYLOR, A. C. & PILLAI, P. A. - The nerve fibres as a system in continuous flow: microcinematographic and electron microscopic demonstrations. Science 136:330, 1962.