Is multiple sclerosis in Brazil and asia alike?

Lana-Peixoto, Marco Aurélio; Lana-Peixoto, Maria Inês V.

doi:10.1590/S0004-282X1992000400002

Abstracts

The clinical picture of 67 consecutive patients with definite multiple sclerosis in Belo Horizonte, Brazil, was analysed. There were 20 patients with the predominant optic-spinal form of the disease and eight with Devic's disease. Visual loss occurred in 43% of the cases as the presenting symptom and in 84% in the course of the illness. Symptoms related to spinal cord and cerebellar involvement were observed in 64% and 52% respectively. The high prevalence of visual and spinal abnormalities at onset and during the course of the illness, the lesser common involvement of the cerebellum and the relative frequency of Devic's disease make multiple sclerosis in Brazil similar to that observed in Eastern countries in distinction to the clinical pattern seen in the United States and Europe.

multiple sclerosis; clinical characteristics; geographical similarities; (Brazil and East Asia countries).

O quadro clínico de 67 pacientes consecutivos com diagnóstico clinicamente definido de esclerose múltipla foi analisado. Vinte destes pacientes apresentavam a forma predominante óptico-espinal da doença e oito pacientes apresentavam doença de Devic. Baixa visual foi observada em 43% dos casos como manifestação inicial e em 84% durante o curso da doença. Sintomas e sinais secundários a acometimento da medula espinal e do cerebelo foram observados em 64% e 52% dos casos respectivamente. A elevada prevalência de anormalidades visuais e espinais, o envolvimento menos frequente do cerebelo e a alta frequência relativa da doença de Devic sugerem que a esclerose múltipla no Brasil apresenta características semelhantes às relatadas em países orientais em distinção ao padrão clínico mais comumente observado nos Estados Unidos e na Europa.

esclerose múltipla; características clínicas; semelhanças geográficas; (Brasil e países da Asia Leste)

Marco Aurélio Lana-Peixoto; Maria Inês V. Lana-Peixoto

Department of Neurology, Federal University of Minas Gerais Medical School, Belo Horizonte, Brazil

SUMMARY

The clinical picture of 67 consecutive patients with definite multiple sclerosis in Belo Horizonte, Brazil, was analysed. There were 20 patients with the predominant optic-spinal form of the disease and eight with Devic's disease. Visual loss occurred in 43% of the cases as the presenting symptom and in 84% in the course of the illness. Symptoms related to spinal cord and cerebellar involvement were observed in 64% and 52% respectively. The high prevalence of visual and spinal abnormalities at onset and during the course of the illness, the lesser common involvement of the cerebellum and the relative frequency of Devic's disease make multiple sclerosis in Brazil similar to that observed in Eastern countries in distinction to the clinical pattern seen in the United States and Europe.

Key words: multiple sclerosis, clinical characteristics, geographical similarities (Brazil and East Asia countries).

RESUMO

O quadro clínico de 67 pacientes consecutivos com diagnóstico clinicamente definido de esclerose múltipla foi analisado. Vinte destes pacientes apresentavam a forma predominante óptico-espinal da doença e oito pacientes apresentavam doença de Devic. Baixa visual foi observada em 43% dos casos como manifestação inicial e em 84% durante o curso da doença. Sintomas e sinais secundários a acometimento da medula espinal e do cerebelo foram observados em 64% e 52% dos casos respectivamente. A elevada prevalência de anormalidades visuais e espinais, o envolvimento menos frequente do cerebelo e a alta frequência relativa da doença de Devic sugerem que a esclerose múltipla no Brasil apresenta características semelhantes às relatadas em países orientais em distinção ao padrão clínico mais comumente observado nos Estados Unidos e na Europa.

Palavras-chave: esclerose múltipla, características clínicas, semelhanças geográficas (Brasil e países da Asia Leste).

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Marco Aurélio Lana-Peixoto, M.D. Departamento de Neurologia, Instituto Hilton Rocha -Av. Anel da Serra 1355 - 30210 Belo Horizonte- MO - Brasil.

1. Allison RT. Disseminated sclerosis in North Wales. Brain 1931, 53:391-430.
2. Batchelor JK, Compston DAS, McDonald WI. The significance of the association between HLA and multiple sclerosis. Br Med Bull 1978, 34:279-284.
3. Bauer HJ. Problems of symptomatic therapy of multiple sclerosis. Neurology 1978, 28:8-20.
4. Bhiglee AL. Multiple sclerosis in a black patient. S Afr Med J 1987, 72:873-875.
5. Callegaro D. Contribuição ao estudo clínico evolutivo da esclerose múltipla: análise de 120 pacientes. Dissertation. Faculdade de Medicina da Universidade de São Paulo. São Paulo, 1989.
6. Compston A. Risk factors for multiple sclerosis: race or place? J Neurol Neurosurg Psychiatry 1990, 53:821-823.
7. Davenport CB. Multiple sclerosis from the standpoint of geographic distribution and race. Arch Neurol Psychiatry 1922, 8:51-58.
8. Detels R, Visscher BR, Malmgren RM, Coulson AM, Lucia MV, Dudley JP. Evidence for lower susceptibility to multiple sclerosis in Japanese-Americans. Am J Epidemiol 1977, 105:303-310.
9. Ebers GC, Bulman DE, Sandovnick AD. A population based study of multiple sclerosis in twins. N Engl J Med 1986, 315:1638-1642.
10. Hung TP, Landsborough D, Hsi MS. Multiple sclerosis in Taiwan. J Neurol Sci 1976, 27:459-485.
11. Isayama Y, Takahashi T, Slümoyama T, Yamadori A. Acute optic neuritis and multiple sclerosis. Neurology 1982, 32:73-76.
12. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvud M, Kapprio J. Genetic susceptibility to multiple sclerosis: a co-twin study of a nationwide series. Arch Neurol 1988, 45:1108-1111.
13. Kuroiwa Y. Neuromyelitis optica. In: Vinken PJ, Bruyn GM, Klawans HL, (eds) : Handbook of Neurology. Amsterdam: Elsevier, 1985, vol 47:397-408.
14. Kuroiwa Y, Igata A, Itahara K, Kishijima S, Tsubaki T, Toyokura Y, Shibiasaki H. Nationwide survey of multiple sclerosis in Japan: clinical analysis of 1084 cases. Neurology 1975, 25:845-851.
15. Kuroiwa Y, Shibasaki H, Tabira T, Itoyama Y. Clinical pictures of multiple sclerosis in Asia. In: Kuroiwa Y, Kurland LT (eds) : Multiple Sclerosis East and West. Basel: Karger, 1982, p 31-42.
16. Kurtzke JF, Beebe GW, Nagler B, Auth TL, Kurland LT, Nefger MD. Studies on natural history of multiple sclerosis: 6. Clinical and laboratory findings at first diagnosis. Acta Neurol Scand 1972, 48:19-46.
17. Kurtzke JF, Park CS, Oh SJ. Multiple sclerosis in Korea: clinical features and prevalence. J Neurol Sci 1968, 6:463-481.
18. Lana-Peixoto MA, Lana-Peixoto MI. The risk of multiple sclerosis developing in patients with isolated idiopathic optic neuritis in Brasil. Arq Neuro-Psiquiat (São Paulo) 1991, 49:279-284.
19. Lancellotti CD, Paslar EAL, D'Andretta C Neto, Atra M, Tilbery CP. Esclerose múltipla: estudo clínico e patológico de um caso. Arq Neuro-Psiquiat (São Paulo) 1989, 47:455-460.

Is multiple sclerosis in Brazil and asia alike?

A esclerose múltipla é semelhante no Brasil e na Asia?

Publication Dates

Publication in this collection
22 Feb 2011
Date of issue
Dec 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Allison RT. Disseminated sclerosis in North Wales. Brain 1931, 53:391-430.

[2] 2. Batchelor JK, Compston DAS, McDonald WI. The significance of the association between HLA and multiple sclerosis. Br Med Bull 1978, 34:279-284.

[3] 3. Bauer HJ. Problems of symptomatic therapy of multiple sclerosis. Neurology 1978, 28:8-20.

[4] 4. Bhiglee AL. Multiple sclerosis in a black patient. S Afr Med J 1987, 72:873-875.

[5] 5. Callegaro D. Contribuição ao estudo clínico evolutivo da esclerose múltipla: análise de 120 pacientes. Dissertation. Faculdade de Medicina da Universidade de São Paulo. São Paulo, 1989.

[6] 6. Compston A. Risk factors for multiple sclerosis: race or place? J Neurol Neurosurg Psychiatry 1990, 53:821-823.

[7] 7. Davenport CB. Multiple sclerosis from the standpoint of geographic distribution and race. Arch Neurol Psychiatry 1922, 8:51-58.

[8] 8. Detels R, Visscher BR, Malmgren RM, Coulson AM, Lucia MV, Dudley JP. Evidence for lower susceptibility to multiple sclerosis in Japanese-Americans. Am J Epidemiol 1977, 105:303-310.

[9] 9. Ebers GC, Bulman DE, Sandovnick AD. A population based study of multiple sclerosis in twins. N Engl J Med 1986, 315:1638-1642.

[10] 10. Hung TP, Landsborough D, Hsi MS. Multiple sclerosis in Taiwan. J Neurol Sci 1976, 27:459-485.

[11] 11. Isayama Y, Takahashi T, Slümoyama T, Yamadori A. Acute optic neuritis and multiple sclerosis. Neurology 1982, 32:73-76.

[12] 12. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvud M, Kapprio J. Genetic susceptibility to multiple sclerosis: a co-twin study of a nationwide series. Arch Neurol 1988, 45:1108-1111.

[13] 13. Kuroiwa Y. Neuromyelitis optica. In: Vinken PJ, Bruyn GM, Klawans HL, (eds) : Handbook of Neurology. Amsterdam: Elsevier, 1985, vol 47:397-408.

[14] 14. Kuroiwa Y, Igata A, Itahara K, Kishijima S, Tsubaki T, Toyokura Y, Shibiasaki H. Nationwide survey of multiple sclerosis in Japan: clinical analysis of 1084 cases. Neurology 1975, 25:845-851.

[15] 15. Kuroiwa Y, Shibasaki H, Tabira T, Itoyama Y. Clinical pictures of multiple sclerosis in Asia. In: Kuroiwa Y, Kurland LT (eds) : Multiple Sclerosis East and West. Basel: Karger, 1982, p 31-42.

[16] 16. Kurtzke JF, Beebe GW, Nagler B, Auth TL, Kurland LT, Nefger MD. Studies on natural history of multiple sclerosis: 6. Clinical and laboratory findings at first diagnosis. Acta Neurol Scand 1972, 48:19-46.

[17] 17. Kurtzke JF, Park CS, Oh SJ. Multiple sclerosis in Korea: clinical features and prevalence. J Neurol Sci 1968, 6:463-481.

[18] 18. Lana-Peixoto MA, Lana-Peixoto MI. The risk of multiple sclerosis developing in patients with isolated idiopathic optic neuritis in Brasil. Arq Neuro-Psiquiat (São Paulo) 1991, 49:279-284.

[19] 19. Lancellotti CD, Paslar EAL, D'Andretta C Neto, Atra M, Tilbery CP. Esclerose múltipla: estudo clínico e patológico de um caso. Arq Neuro-Psiquiat (São Paulo) 1989, 47:455-460.