The pathological findings of the cerebral involvement in deep-seated fungal infections in routine autopsy is reported. In 42 cases of mycotic infections studied among 3,966 autopsies, there were 8 cases of cryptococosis and 2 of aspergillosis of the brain, showing a very low frequency of central nervous system involvement, occuring in a proportion of 1:400 autopsies. The histopathological findings of the brain in cases of cryptococosis showed the spectrum of inflamatory reactions already described, although most of the cases presented with mild to severe meningitis with large number of giant cells, and slight degree of involvement of the nervous tissue. The cases of aspergillosis showed a pattern of severe necrotizing meningoencephalitis with large number of fungi. The paper points out the role of the histological examination in the identification of the fungi in tissues and their morphologic reactions.