Eleven cases of schizophrenia were treated with guanethidine, substance considered as a sympathicoplegic drug. In the author's opinion, the remarkable and significative results achieved justify a new approach in the investigation of the schizophrenia etiopathogenesis. As from the achieved elements, he considers plausible a "schizopherenia psychosomatic theory". However, he refuses entering the infructuous although attractive speculation field. He prefers to wait until the pharmacologists and physiologists can furnish more precise data regarding the guanetidine activity mechanism and new trials can corroborate the results achieved by him, and after that he will divulge his theory.