Synthesis and Characterization of Membranes Produced from Gelatin and Poly (ethylene glycol)

This study focuses on the development and characterization of gelatin-based membranes with varying concentrations of poly(ethylene glycol) (PEG) as potential cost-effective skin substitutes for burn wound treatment. In lowand middle-income countries, where burn injuries pose a significant public health challenge, affordable solutions are crucial. Gelatin/PEG membranes were prepared with PEG concentrations ranging from 3% to 30%. Fourier Transform Infrared Spectroscopy (FT-IR) analysis demonstrated an interaction between gelatin and PEG, indicating cohesive integration through hydrogen bonding, while mechanical tests showed an initial enhancement in Young’s modulus up to a 10% PEG concentration, suggesting improved interaction. Swelling tests revealed that higher PEG concentrations led to increased swelling capacity and reduced mass loss. Scanning electron micrographs supported these findings, showing an irregular surface and the formation of PEG agglomerates, which contributed to improved mechanical resistance. These gelatin-PEG membranes offer a promising avenue for cost-effective skin substitutes, addressing the need for accessible solutions in burn wound care, especially in resource-constrained settings. Further research and clinical validation are essential to assess their efficacy and safety in practical applications, potentially revolutionizing burn wound treatment.

Keywords:
Polyethylene glycols; Gelatin; Burns; Wound healing.

Gelatin/PEG membranes for skin substitutes.

Cost-effective solution for burn wound treatment.