Effects of magnesium sulphate on the onset time of rocuronium at different doses: a randomized clinical trial

Abstract

Background and aims:

Rocuronium may provide excellent onset time, but high doses are required for effective action. Several strategies have managed to shorten rocuronium onset time, including the use of Magnesium Sulphate (MgSO₄).

Methods:

One hundred and eighty patients were randomized into six groups according to rocuronium dose received (0.3, 0.6 or 1.2 mg.kg^-1) and the administration of saline or MgSO⁴ (60 mg.kg^-1). Correlations between tissue perfusion and rocuronium onset time was determined by variations in perfusion index.

Results:

Median (quartiles) rocuronium onset times were 85.5 (74.0–92.0); 76.0 (52.0–87.0) and 50.0 (41.0–59.5) seconds for 0.3, 0.6 mg.kg^-1 and 1.2 mg.kg^-1 doses, respectively. MgSO₄ decreased rocuronium onset at doses of 0.3 mg.kg^-1 (60.0 [48.0–74.3] seconds) and 0.6 mg.kg^-1 (44.0 [39.0–49.0] seconds) but not at 1.2 mg.kg^-1 (38.0 [33.5–56.3] seconds) (p < 0.001). Perfusion index variations in groups that received MgSO₄ were greater than in controls. A negative correlation between shorten onset and increased perfusion index was observed in rocuronium doses of 0.3 mg.kg^-1 (r = -0.50; p < 0.001) and 0.6 mg.kg^-1 (r = -0.424; p < 0.001), but not for 1.2 mg.kg^-1 dose (r = -0.25; p = 0.07).

Conclusion:

MgSO₄ reduces rocuronium onset time at doses of 0.3 mg.kg^-1 and 0.6 mg.kg^-1 being that the latter has a similar effect when compared to the dose of 1.2 mg.kg^-1, with or without the use of MgSO₄.

KEYWORDS
Magnesium sulphate; Neuromuscular blocking agents; Rocuronium