Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika<sup/>

Venâncio, Leonardo Gleygson Angelo; Muniz, Lilian Ferreira; Hora, Lais Cristine Delgado da; Silva, Jéssica Dayane da; Cavalcanti, Gabriela Silva Teixeira; Leal, Mariana de Carvalho; Caldas Neto, Sílvio da Silva

doi:10.1016/j.bjorl.2023.101342

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Brazilian Journal of Otorhinolaryngology

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Sumário

Review article • Braz. j. otorhinolaryngol. 90 (01) • 2024 • https://doi.org/10.1016/j.bjorl.2023.101342 copy

Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika^☆ ☆ Peer Review under the responsibility of Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objectives

To identify and understand the evidence regarding hearing changes related to acquired Dengue, Chikungunya, and Zika virus infection in adult individuals.

Methods

A scoping review was performed according to the recommendations of The Joanna Briggs Institute and guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews in the Embase, PubMed/Medline, ScienceDirect, Scopus, and Web of Science databases without restriction on language and year of publication. Case studies, observational studies, and clinical trials reporting hearing loss in adult subjects (>18-60 years of age) of both sexes with DENV, CHIKV, or ZIKV diagnosed by positive molecular/serological examination by RT-PCR or IgM/IgG by ELISA method were included.

Results

Thirteen studies met the inclusion criteria and were selected for review. The occurrence of auditory symptoms caused by arboviroses and the presence of permanent or transient sensorineural hearing loss was variable in adults.

Conclusions

Dengue, Chikungunya, and Zika infections in adults are associated with a variety of auditory symptoms. The frequency of permanent or transient sensorineural hearing loss is low but not negligible.

Keywords
Zika virus; Chikungunya virus; Dengue; Hearing disorders; Auditory perceptual disorders

Highlights

Hearing alteration may occur during Dengue, Chikungunya, and Zika infections.

Otalgia, hypoacusis, vertigo and tinnitus were the most common symptoms.

Sensorineural hearing loss was more notiaceable in adults exposed to Zika virus.

The actual effect of arboviruses on hearing from adults is unknown.

Arbovirus	Author/year	Country	Aim	Study design	Sample (N)	Mean age (years)	Hearing assessment method	Main conclusions
Dengue	Denis et al., 2003	Brazil	Evaluate patients with dengue who present with otorhinolaryngological symptoms	Cross-sectional study	30	33.7	Self-reporting	The clinical suspicion of dengue is essential because of the different otorhinolaryngological manifestations
	Diniz et al., 2021	Brazil	To report a case of aseptic meningitis, acute renal failure, and sensorineural hearing loss in a 42-year-old man with severe dengue fever	Case report	1	42	Audiometry	Six-month follow-up showed persistent deafness, suggesting an association between dengue and hearing loss
	Mughal et al., 2022	Pakistan	To report a case of unilateral sensorineural hearing loss after dengue	Case report	1	46	Rinne test, Webber test and audiometry	Sensory sensorineural hearing loss is a rare presentation in dengue that doctors need to investigate
	Rahme et al., 2020	Brazil	To describe four patients who presented with serologically confirmed dengue infection and cochleovestibular manifestations	Case report	4	55	Audiometry, vídeo head impulse test and acufenometry	The cochleovestibular manifestations in dengue are heterogeneous
	Ribeiro et al., 2015	Brazil	To present a case of dengue hemorrhagic fever that evolved with sensorineural hearing loss	Case report	1	60	Audiometry	No other cause was found for sudden deafness and the correlation with dengue fever was questioned
	Soni et al., 2021	India	To explore the association of dengue with hearing loss	Prospective cohort	10	29	Audiometry, tympanometry, brainstem auditory evoked potential, and steady state	Hearing loss in dengue, even if mild, is irreversible. The cause of the loss has not yet been found, and further studies are needed
Chikungunya	Couturier et al., 2012	France	To measure the frequency and risk factors for rheumatic manifestations after chikungunya infection and to assess their impact on quality of life	Prospective cohort	227	50.3	Questionnaire	Medical follow-up was recommended to support possible associated depression and anxiety
	Dutta et al., 2011	India	Finding the prevalence of chikungunya in Assam, northeast India	Cross-sectional study	10	NR	Audiometry	Highlights the importance of an epidemiological and entomological investigation for detection of the emergence of chikungunya
	Jain et al., 2018	India	Report two cases of chikungunya encephalitis	Case report	2	32.5	NR	Neurological complications may occur during the infectious process or after a period of 15-20 days
Zika	Aspahan et al., 2019	Brazil	To report a case of neuromyelitis optical spectrum disorder associated with Zika virus infection	Case report	1	35	NR	The pathophysiology of neurological disorders related to arbovirus infections has not yet been established, and further research is needed for this purpose
	Martins et al., 2017	Brazil	To characterize the otologic findings in two adult patients, post-infection by Zika virus	Case study series	2	45	Audiometry, tympanometry, brainstem evoked potentials, transient and distortion product evoked otoacoustic emissions	Audiological findings demonstrate possible neuronal involvement in the complaints presented, associated or not with the peripheral component, in infected patients
	Tappe et al., 2015	Germany	To report an acute Zika infection that presented with bilateral hearing difficulties during illness	Case report	1	45	Self-reporting	The cause of hearing difficulties remains unclear. Increased clinical and laboratory awareness may help diagnose outside epidemic events
	Vinhaes et al., 2016	Brazil	Report one confirmed and two probable cases of Zika with transient sensorineural hearing loss	Case report	3	23	Audiometry	An association between Zika infection and transient hearing loss has been suggested

Arbovirus	Study	Hearing results											Change in the grade of hearing loss
		Normal hearing (N)	Symptoms and complaints					Improvement of symptoms	Hearing loss
			Hypoacusis	Hyperacusis	Otalgia	Vertigo/tinnitus	Tinnitus		(N)	Type	Grade	Ear
Dengue (n = 47)	Denis et al., 2003	‒	‒	‒	11	6	2	NR	‒	‒	‒	‒	‒
	Diniz et al., 2021	‒	‒	‒	‒	1	‒	NR	1	SN	Moderately severe on right and profound on left	Both	Yes
	Mughal et al., 2022	‒	1	‒	‒	‒	1	Yes	1	SN	Profound	Left	Yes
	Rahme et al., 2020	1	‒	1	‒	2	3	Yes	2	SN	Mild on right and profound on left	Left	Yes
	Ribeiro et al., 2015	‒	‒	‒	‒	‒	‒	‒	1	SN	Profound	Both	No
	Soni et al., 2021	7	2	‒	‒	‒	1	NR	3	SN	Mild (NS)	Both	NS
Chikungunya	Couturier et al., 2012	‒	13	‒	‒	‒	‒	NR	‒	‒	‒	‒	‒
	Dutta et al., 2011	‒	‒	‒	‒	‒	‒	‒	1	SN	Mild to severe (NS)	Both	NS
	Jain et al., 2018	‒	1	‒	‒	‒	‒	NR	‒	‒	‒	‒	‒
Zika	Aspahan et al., 2019	‒	1	‒	‒	1	‒	NR	‒	‒	‒	‒	‒
	Martins et al., 2017	1	‒	‒	‒	2	2	NR	1	SN	Moderate (NS)	Left	NS
	Tappe et al., 2015	‒	1	‒	‒	‒	‒	Yes	‒	‒	‒	‒	‒
	Vinhaes et al., 2016	1	‒	‒	‒	1	2	NR	2	SN	Severe on right and profound on left	Both	Yes

Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Sede da Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico Facial, Av. Indianópolia, 1287, 04063-002 São Paulo/SP Brasil, Tel.: (0xx11) 5053-7500, Fax: (0xx11) 5053-7512 - São Paulo - SP - Brazil
E-mail: revista@aborlccf.org.br

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Peer Review under the responsibility of Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.

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Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika☆ ☆ Peer Review under the responsibility of Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.

Abstract

Objectives

Methods

Results

Conclusions

Highlights

Does a patient with acquired arbovirus infection have a hearing impairment? A scoping review of hearing changes in an adult with Dengue, Chikungunya, and Zika^☆ ☆ Peer Review under the responsibility of Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial.