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Kano-Sueoka et al. (1979Kano-Sueoka T, Cohen DM, Yamaizumi Z, Nishimura S, Mori M, Fujiki H. Phosphoethanolamine as a growth factor of a mammary carcinoma cell line of rat. Proc Natl Acad Sci. 1979;76(11):5741-4.) |
Not applicable |
Phosphoethanolamine induced tumor proliferation |
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Arruda et al. (2011Arruda MSP, Correa MA, Venturini J, Félix MC, De Rosis AMB, Galhiane MS, et al. The effect of phosphoethanolamine intake on mortality and macrophage activity in mice with solid Ehrlich tumors. Brazilian Arch Biol Technol. 2011;54(6):1203-10.) |
n=20, group treated with 800 mg/kg PHOS-S; n=20, control group |
PHOS-S has the capacity to alter macrophage metabolism |
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Ferreira et al. (2011Ferreira AK, Meneguelo R, Neto SC, Chierice GO, Maria DA. Synthetic phosphoethanolamine induces apoptosis through caspase-3 pathway by decreasing expression of Bax/Bad protein and changes cell cycle in melanoma. J Cancer Sci Ther. 2011;3(3):53-9.) |
30 mice (divided into 4 treatment groups: 7 mg/kg PHOS-S, 14 mg/kg PHOS-S, 7 mg/kg Taxol and saline control) |
PHOS-S showed anticarcinogenic capacity, inhibiting tumor growth by induction of apoptosis |
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Ferreira et al. (2012aFerreira AK, Meneguelo R, Pereira A, Mendonça Filho OR, Chierice GO, Maria DA. Anticancer effects of synthetic phosphoethanolamine on Ehrlich ascites tumor: an experimental study. Anticancer Res. 2012a;32(1):95-104.) |
The mice were divided into different groups (n=5): 35 mg/kg/day PHOS-S, 70 mg/kg/day PHOS-S and an untreated control group |
PHO-S presented cytotoxic potential against tumor cells via several mechanisms |
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Ferreira et al. (2012bFerreira AK, Meneguelo R, Marques FLN, Radin A, Filho OMR, Neto SC, et al. Synthetic phosphoethanolamine a precursor of membrane phospholipids reduce tumor growth in mice bearing melanoma B16-F10 and in vitro induce apoptosis and arrest in G2/M phase. Biomed Pharmacother. 2012b;66(7):541-8.) |
The mice were divided into four groups (n=5): 50 mg/kg PHOS-S, 100mg/kg PHOS-S and an untreated control group |
PHOS-S showed inhibitory capacity in B16F10 cells |
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Ferreira et al. (2013Ferreira AK. Alquil fosfatado sintético precursor dos fosfolipídios de membrana celular com potencial efeito antitumoral e apoptótico em modelos de tumores experimentais [Tese doutorado]. São Paulo: Faculdade de Medicina, Universidade de São Paulo; 2013.a) |
Not applicable |
PHOS-S presented anticarcinogenic capacity, inhibiting tumor growth by inducing apoptosis and cell cycle blockade |
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Ferreira et al. (2013Ferreira AK. Alquil fosfatado sintético precursor dos fosfolipídios de membrana celular com potencial efeito antitumoral e apoptótico em modelos de tumores experimentais [Tese doutorado]. São Paulo: Faculdade de Medicina, Universidade de São Paulo; 2013.c) |
The mice were divided into different groups (n=5): 40 mg/kg PHOS-S; 80 mg/kg PHOS-S; 1 mg/kg all-trans retinoic acid (ATRA) and 10 mg/kg daunorubicin (DA) (the last two were positive controls). In addition, mice were treated with 100 mL of PBS (vehicle) to induce the same stress conditions of treatment in the control animals |
PHOS-S presented cytotoxic capacity against leukemic cells |
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Ferreira et al. (2013Ferreira AK. Alquil fosfatado sintético precursor dos fosfolipídios de membrana celular com potencial efeito antitumoral e apoptótico em modelos de tumores experimentais [Tese doutorado]. São Paulo: Faculdade de Medicina, Universidade de São Paulo; 2013.b) |
The mice were divided into different groups (n=5): 50 mg/kg/day PHOS-S, 100 mg/kg/day PHOS-S and 10 mg/kg/day sunitinib |
PHOS-S presented antiangiogenic and antimetastatic capacity |
