Chemical constituents and bioactivities of Rosa roxburghii: a systematic review

WANG, Jianmei; WANG, Guopan; WANG, Xianting; QIN, Lin; XU, Chong; SHE, Xiangqian; HE, Yuqi; TAN, Daopeng

doi:10.1590/fst.72722

Jianmei WANG

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

Guopan WANG

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

Xianting WANG

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

https://orcid.org/0000-0002-7985-4038

Lin QIN

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

Chong XU

Institute of Traditional Chinese Medicine Preparation, Chongqing Traditional Chinese Medicine Hospital, Chongqing Academy of Traditional Chinese Medicine, Chongqing, China

Xiangqian SHE

Guizhou Keytrum Bio-Tech Co. Ltd., Guiyang, China

Yuqi HE ^**Corresponding author: 1474755772@qq.com; yqhe.pharm@foxmail.com

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

Daopeng TAN ^**Corresponding author: 1474755772@qq.com; yqhe.pharm@foxmail.com

Guizhou Engineering Research Center of Industrial Key-technology for Dendrobium Nobile, School of Pharmacy, Zunyi Medical University, Zunyi, China

*Corresponding author: 1474755772@qq.com; yqhe.pharm@foxmail.com

Conflict of interest

All authors have no conflicts of interest to declare.

No.	Compound name	Formula	Molecular weight (g/mol)	Part of plant	Ref.
1	Myricetin	C₁₅H₁₀O₈	318.24	Fruit	Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202... ; Wang et al., 2013Wang, H., Huang, C., Liu, S. Y., & Du, W. (2013). Determination of myricetin and quercetin in Rose roxburghii by HPLC. Zhongguo Shiyan Fangjixue Zazhi, 19(1), 109-111.; Zhang, 2005Zhang, X. L. (2005). Investigation on flavonoids from Rosa roxburghii Tratt. and its biological activity (Master’s thesis). East China Normal University, Shanghai.
2	Quercetin	C₁₅H₁₀O₇	302.24	Fruit	Hao et al., 2018Hao, M. H., Zhang, F., Liu, X. X., Zhang, F., Wang, L. J., Xu, S. J., Zhang, J. H., Ji, H. L., & Xu, P. (2018). Qualitative and quantitative analysis of catechin and quercetin in flavonoids extracted from Rosa roxburghii Tratt. Tropical Journal of Pharmaceutical Research, 17(1), 71-76. http://dx.doi.org/10.4314/tjpr.v17i1.11. PMid:30853875. http://dx.doi.org/10.4314/tjpr.v17i1.11... ; Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202... ; Porter et al., 2012Porter, E. A., van den Bos, A. A., Kite, G. C., Veitch, N. C., & Simmonds, M. S. (2012). Flavonol glycosides acylated with 3-hydroxy-3-methylglutaric acid as systematic characters in Rosa. Phytochemistry, 81, 90-96. http://dx.doi.org/10.1016/j.phytochem.2012.05.006. PMid:22721781. http://dx.doi.org/10.1016/j.phytochem.20... ; Wang et al., 2013Wang, H., Huang, C., Liu, S. Y., & Du, W. (2013). Determination of myricetin and quercetin in Rose roxburghii by HPLC. Zhongguo Shiyan Fangjixue Zazhi, 19(1), 109-111.; Wang et al., 2014Wang, Z. W., Shen, S., & Hu, X. B. (2014). Extracting total flavonoids from Rosa roxburghii Tratt with ultrasonic wave and determination by HPLC. Hubei Agricultural Sciences, 53(19), 4684-4687.; Xie et al., 2017Xie, G. F., Xu, X. Y., Wang, R., Liu, Z. G., Zhou, X. L., & Yang, H. T. (2017). Analysis of phenolic, Vc and antioxidant activity of fruits and leaves of Rosa sterilis D. Shi. Zhiwu Kexue Xuebao, 35(1), 122-127.; Zhang, 2005Zhang, X. L. (2005). Investigation on flavonoids from Rosa roxburghii Tratt. and its biological activity (Master’s thesis). East China Normal University, Shanghai.
3	Dihydroapigenin	C₁₅H₁₂O₅	273.07	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
4	Kaempferol	C₁₅H₁₀O₆	286.24	Fruit	Zhang et al., 2017Zhang, H. H., Liu, L. Y., Wu, C. E., Li, T. T., Fan, G. J., & Ying, R. F. (2017). Semi-bionic extraction of flavonoids from Rosa roxburghii Tratt. Journal of Nanjing Forestry University, 41(6), 47-53.; Zhang, 2005Zhang, X. L. (2005). Investigation on flavonoids from Rosa roxburghii Tratt. and its biological activity (Master’s thesis). East China Normal University, Shanghai.
5	Luteolin	C₁₅H₁₀O₆	286.24	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
6	Isoquercitrin	C₂₁H₂₀O₁₂	464.38	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
7	Quercitrin	C₂₁H₂₀O₁₁	448.38	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
8	Quercetin-3-O-xyloside	C₂₀H₁₈O₁₁	434.35	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
9	Quercetin-3-O-rutinoside	C₂₇H₃₀O₁₆	610.51	Fruit	Yu et al., 2020Yu, Y. H., Gu, W. T., Ding, Z. H., Chen, S. Q., Song, Y. T., & Wang, Y. (2020). Optimization on biotransformation of quercetin glycosides in Rosa roxburghii by β-glucosidase. Journal of Food Science and Technology, 38(5), 109-118.
10	Quercetin-3-O-rhamnoside	C₂₁H₂₀O₁₁	448.38	Fruit	Yu et al., 2020Yu, Y. H., Gu, W. T., Ding, Z. H., Chen, S. Q., Song, Y. T., & Wang, Y. (2020). Optimization on biotransformation of quercetin glycosides in Rosa roxburghii by β-glucosidase. Journal of Food Science and Technology, 38(5), 109-118.
11	Quercetin-3-O-glucoside	C₂₁H₂₀O₁₂	464.37	Fruit	Yu et al., 2020Yu, Y. H., Gu, W. T., Ding, Z. H., Chen, S. Q., Song, Y. T., & Wang, Y. (2020). Optimization on biotransformation of quercetin glycosides in Rosa roxburghii by β-glucosidase. Journal of Food Science and Technology, 38(5), 109-118.
12	Rutin	C₂₇H₃₄O₁₆	614.55	Fruit	Tian et al., 2009aTian, H. Z., Zhou, Y. M., Zhao, Y. B., Zang, J., & Hu, R. (2009a). Quantitative analysis of rutin in Rosa roxburghii Tratt fruit by HPLC. Shipin Kexue, 30(10), 203-205.; Wang et al., 2014Wang, Z. W., Shen, S., & Hu, X. B. (2014). Extracting total flavonoids from Rosa roxburghii Tratt with ultrasonic wave and determination by HPLC. Hubei Agricultural Sciences, 53(19), 4684-4687.; Yang et al., 2019Yang, Y., Li, S. Y., & Guo, Q. (2019). Study on extraction and antibactereial effect of rutin form Rosa roxburghii. Biological Chemical Engineering, 5(6), 28-30.
13	Quercetin-3-O-D-xyloside	C₂₀H₁₈O₁₁	434.35	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
14	Quercetin 3-O-[(6-O-3-hydroxy-3-methylglutaryl)-β-glucoside]	C₂₇H₂₉NO₁₆	623.52	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
15	Kaempferol 3-O-[(X-O-3-hydroxy-3-methylglutaryl)-β-galactoside]	C₂₇H₂₈O₁₅	592.50	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
16	Kaempferol 3-O-[(3-hydroxy-3-methylglutaryl)-β-glucuronide]	C₃₃H₃₄O₂₂	782.61	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
17	Catechin	C₁₅H₁₄O₆	290.28	Fruit	Hao et al., 2018Hao, M. H., Zhang, F., Liu, X. X., Zhang, F., Wang, L. J., Xu, S. J., Zhang, J. H., Ji, H. L., & Xu, P. (2018). Qualitative and quantitative analysis of catechin and quercetin in flavonoids extracted from Rosa roxburghii Tratt. Tropical Journal of Pharmaceutical Research, 17(1), 71-76. http://dx.doi.org/10.4314/tjpr.v17i1.11. PMid:30853875. http://dx.doi.org/10.4314/tjpr.v17i1.11... ; Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202... ; Liang et al., 2001Liang, G. Y., Zheng, Y. Y., He, Z. Y., Zhang, J. X., & Yang, J. G. (2001). Studies on the compound of fruit juice of Rosa roxburghii Tratt. Guizhou Science, 3, 5-7.; Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091... ; Xie et al., 2017Xie, G. F., Xu, X. Y., Wang, R., Liu, Z. G., Zhou, X. L., & Yang, H. T. (2017). Analysis of phenolic, Vc and antioxidant activity of fruits and leaves of Rosa sterilis D. Shi. Zhiwu Kexue Xuebao, 35(1), 122-127.
18	Epicatechin	C₁₅H₁₄O₆	290.27	Fruit	Zeng, 2017Zeng, F. F. (2017). Tudies on principal phytochemical composition and biological activities of Cili fruit (Master’s thesis). Zhejiang University, Hangzhou.
19	Epigallocatechin	C₁₅H₁₄O₇	306.27	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
20	Icariin I	C₂₇H₃₀O₁₁	530.53	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
21	Protocentaurea B4	C₂₁H₁₈O₉	414.37	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
22	Epicatechin-5-O-β-D-glucopyranoside	C₂₁H₂₄O₁₁	452.41	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
23	Gallocatechin	C₁₅H₁₄O₇	306.27	Fruit	Yang et al., 2020Yang, Q.-Q., Zhang, D., Farha, A. K., Yang, X., Li, H.-B., Kong, K.-W., Zhang, J.-R., Chan, C.-L., Lu, W.-Y., Corke, H., & Gan, R.-Y. (2020). Phytochemicals, essential oils, and bioactivities of an underutilized wild fruit Cili (Rosa roxburghii). Industrial Crops and Products, 143, 111928. http://dx.doi.org/10.1016/j.indcrop.2019.111928. http://dx.doi.org/10.1016/j.indcrop.2019...
24	Phloridzin	C₂₁H₂₄O₁₀	436.41	Fruit	Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...

No.	Compound name	Formula	Molecular weight (g/mol)	Part of plant	Ref.
25	Ursolic acid	C₃₀H₄₈O₃	456.71	Fruit	Dai et al., 2018Dai, T. T., Li, Q. J., Chen, X. Y., Wu, N. Y. Y., & Yang, X. S. (2018). Extraction and determination of total triterpenoids of Rosa roxburghii Tratt. Journal of Guizhou Normal University, 36(3), 36-39.
26	Roxburic acid	C₃₀H₄₈O₆	504.70	Fruit	Liang, 1987Liang, G. Y. (1987). The isolation and structure of roxburic acid. Yao Xue Xue Bao, 22(2), 121-125. PMid:3618237.
27	Euscaphic acid	C₃₀H₄₈O₅	488.70	Fruit	Dai et al., 2015Dai, T. T., Li, Q. J., Nan, Y., & Yang, X. S. (2015). Chemical components of antioxidant activity parts of Rosa roxburghii fruit. Zhongguo Shiyan Fangjixue Zazhi, 21(21), 62-65.; Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.; Li et al., 2016cLi, Q. J., Nan, Y., Yang, Y., Wang, D. P., & Yang, X. S. (2016c). Simultaneous determination of two triterpenoids components from Rose roxburghii by HPLC. Guizhou Agricultural Sciences, 44(9), 125-128.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.; Liu & Yuan, 2021Liu, Y. X., & Yuan, X. H. (2021). Study on technology extracting rosolic acid of Rosa roxbunghii Tratt. pomace. Hubei Agricultural Sciences, 60(5), 103-107.
28	1α,2β,3β,19α-tetrahydroxyurs-12-en-28-oic acid	C₃₀H₄₈O₆	504.71	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.
29	2α,3α,19α-trihydroxy-olean-12-en-28-oicacid28-O-β-D-glucopyranoside	C₃₆H₅₈O₁₀	650.85	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.
30	Kaiiichigoside F1	C₃₆H₅₈O₁₀	650.85	Fruit, Leaf	Dai et al., 2015Dai, T. T., Li, Q. J., Nan, Y., & Yang, X. S. (2015). Chemical components of antioxidant activity parts of Rosa roxburghii fruit. Zhongguo Shiyan Fangjixue Zazhi, 21(21), 62-65.; Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.; Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.; Li et al., 2016bLi, Q. J., Nan, Y., Yang, Y., Wang, D. P., & Yang, X. S. (2016b). Determination of kaiiichigeside F1 from the medical and edible plants of Rose roxburghii by HPLC. Chinese Journal of Ethnomedicine and Ethnopharmacy, 25(9), 22-23.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.; Tian et al., 2009bTian, Y., Cao, P. X., Liang, G. Y., & Xu, B. X. (2009b). An investigation in chemical constituents of chestnut rose(Rosa roxburghii) leaves. Journal of Mountain Agriculture and Biology, 28(4), 366-368.
31	Rosamultin	C₃₆H₅₈O₁₀	650.85	Fruit, Leaf	Dai et al., 2015Dai, T. T., Li, Q. J., Nan, Y., & Yang, X. S. (2015). Chemical components of antioxidant activity parts of Rosa roxburghii fruit. Zhongguo Shiyan Fangjixue Zazhi, 21(21), 62-65.; Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.; Tian et al., 2009bTian, Y., Cao, P. X., Liang, G. Y., & Xu, B. X. (2009b). An investigation in chemical constituents of chestnut rose(Rosa roxburghii) leaves. Journal of Mountain Agriculture and Biology, 28(4), 366-368.
32	Potentilanoside B	C₃₆H₅₆O₁₀	648.83	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.; Liang et al., 2019aLiang, M. L., Li, Q., Long, Y. B., Li, Y., Li, P., & Yuan, X. H. (2019a). Identification of chemical constituents of Rosa roxbunghii and their antibacterial activities. Guizhou Agricultural Sciences, 47(5), 10-13.
33	1β-hydroxyeuscaphic acid	C₃₀H₄₈O₆	504.71	Fruit	Dai et al., 2015Dai, T. T., Li, Q. J., Nan, Y., & Yang, X. S. (2015). Chemical components of antioxidant activity parts of Rosa roxburghii fruit. Zhongguo Shiyan Fangjixue Zazhi, 21(21), 62-65.; Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.; Li et al., 2016cLi, Q. J., Nan, Y., Yang, Y., Wang, D. P., & Yang, X. S. (2016c). Simultaneous determination of two triterpenoids components from Rose roxburghii by HPLC. Guizhou Agricultural Sciences, 44(9), 125-128.
34	Arjunic acid	C₃₀H₄₈O₅	488.71	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.
35	Tormentic acid	C₃₀H₄₈O₅	488.71	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.
36	Euscaphic acid	C₃₀H₄₈O₅	488.71	Fruit	Liang, 1986Liang, G. Y. (1986). Research on the chemical composition of Rosa roxburghii Tratt. Chinese Herbal Medicines, 17(11), 4-6.
37	β-Sitosterol	C₂₉H₅₀O	414.70	Leaf	Tian et al., 2009bTian, Y., Cao, P. X., Liang, G. Y., & Xu, B. X. (2009b). An investigation in chemical constituents of chestnut rose(Rosa roxburghii) leaves. Journal of Mountain Agriculture and Biology, 28(4), 366-368.
38	Platyconic acid A	C₃₀H₄₆O₈	534.69	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
39	24-Hydroxytormentic acid	C₃₀H₄₈O₆	504.71	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
40	Ganoderic Acid C2	C₃₀H₄₆O₈	534.69	Seed	Ding et al., 2020Ding, Y.-T., Zheng, Z.-H., Zhao, R.-Y., Zhang, N., Sun, Y.-J., Li, J.-H., Wang, J.-H., Luo, J., Jia, S.-S., & Sun, Y.-K. (2020). Rapid identification of chemical constituents in psoralea coryifolia by UPLC-Q-TOF-MSE combined with unifi informatics platform. Journal of Chinese Mass Spectrometry Society, 41(1), 76-86.
41	Arjunetin	C₃₆H₅₈O₁₀	650.85	Fruit	Dai et al., 2015Dai, T. T., Li, Q. J., Nan, Y., & Yang, X. S. (2015). Chemical components of antioxidant activity parts of Rosa roxburghii fruit. Zhongguo Shiyan Fangjixue Zazhi, 21(21), 62-65.; Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.; Singh et al., 2004Singh, D. V., Gupta, M. M., Tripathi, A. K., Prajapati, V., & Kumar, S. (2004). Arjunetin from terminalia arjuna as an insect feeding-deterrent and growth inhibitor. Phytotherapy Research, 18(2), 131-134. http://dx.doi.org/10.1002/ptr.1383. PMid:15022165. http://dx.doi.org/10.1002/ptr.1383...
42	2-oxo pomolic acid	C₃₁H₄₈O₅	500.72	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.
43	β-Daucosterol	C₃₅H₆₀O₆	576.86	Leaf	Tian et al., 2009bTian, Y., Cao, P. X., Liang, G. Y., & Xu, B. X. (2009b). An investigation in chemical constituents of chestnut rose(Rosa roxburghii) leaves. Journal of Mountain Agriculture and Biology, 28(4), 366-368.
44	2α,3α,19α,24-tetrahydroxyolean-12-en-28-oic-acid 28-O-β-D-glucopyranosyl ester	C₃₆H₅₈O₁₂	682.85	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.
45	2α,3α,19α -trihydroxy-olean-12-en-28-oic acid 28-O-β-D-glucopyranoside	C₃₆H₅₈O₁₁	666.85	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863.

No.	Compound name	Formula	Molecular weight (g/mol)	Part of plant	Ref.
46	Ascorbic acid	C₆H₈O₆	178.14	Fruit	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.; Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202... ; Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091... ; Wang & An, 2013Wang, L. L., & An, H. M. (2013). Optimized HPLC method for analyzing Vc content in Rosa roxburghii fruits. Xiandai Shipin Keji, 29(2), 397-400.
47	Lactic acid	C₃H₆O₃	90.08	Root, Fruit	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.; Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
48	Tartaric acid	C₄H₆O₆	150.09	Root	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.; Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202...
49	Oxalic acid	C₂H₂O₄	90.03	Fruit	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.
50	Succinic acid	C₄H₆O₄	118.09	Flower	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.
51	Malic acid	C₄H₆O₅	134.09	Fruit	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.; Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
52	Protocatechuic acid	C₇H₆O₄	154.12	Fruit	Liang, 1986Liang, G. Y. (1986). Research on the chemical composition of Rosa roxburghii Tratt. Chinese Herbal Medicines, 17(11), 4-6.
53	Citric acid	C₆H₈O₇	192.12	Fruit	An et al., 2011An, H. M., Liu, M., Yang, M., & Fan, W. G. (2011). Analysis of main organic acid compositions in Rosa roxburghii Tratt. Zhongguo Nong Ye Ke Xue, 44(10), 2094-2100.; Liu et al., 2016Liu, M. H., Zhang, Q., Zhang, Y. H., Lu, X. Y., Fu, W. M., & He, J. Y. (2016). Chemical analysis of dietary constituents in Rosa roxburghii and Rosa sterilis fruits. Molecules, 21(9), 1204. http://dx.doi.org/10.3390/molecules21091204. PMid:27618004. http://dx.doi.org/10.3390/molecules21091...
54	P-coumaric acid	C₉H₈0₃	164.16	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
55	Gallic acid	C₇H₆O₅	170.12	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
56	Syringic acid	C₉H₁₀O₅	198.17	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
57	p-hydroxybenzoic acid	C₇H₆O₃	138.12	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
58	Caffeic acid	C₉H₈O₄	180.16	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
59	Gallic acid	C₇H₆O₅	170.12	Fruit, Leaf	Xie et al., 2017Xie, G. F., Xu, X. Y., Wang, R., Liu, Z. G., Zhou, X. L., & Yang, H. T. (2017). Analysis of phenolic, Vc and antioxidant activity of fruits and leaves of Rosa sterilis D. Shi. Zhiwu Kexue Xuebao, 35(1), 122-127.
60	Pyrogallic acid	C₆H₆O₃	126.11	Fruit	Li et al., 2016aLi, Q. J., Nan, Y., Qin, J. J., Yang, Y., Hao, X. J., & Yang, X. S. (2016a). Chemical constituents from medical and edible plants of Rosa roxburghii. Zhongguo Zhongyao Zazhi, 41(3), 451-455. PMid:28868863. [[Q11: Q11]]
61	Ellagic acid	C₁₄H₆O₈	302.19	Fruit	Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202... ; Liang et al., 2019bLiang, Q., Wu, Q., Wu, J. F., Li, L. L., Chen, W. S., & Jiang, F. (2019b). Investigation of extraction process and establishment of content determination method for Rosa roxburghii root polyphenols. Lishizhen Medicine and Materia Medica Research, 30(2), 319-322.; Tan et al., 2019Tan, D. H., Wang, P. Q., Zhang, S., Zhao, M., Liu, Y., Zhang, M., & Gao, X. (2019). Study on content determination of ellagic acid in different medicinal parts of Rosa roxburghii and in vitro antioxidant activity of its ethanol extract. China Pharmacy, 30(9), 1236-1240.; Xie et al., 2017Xie, G. F., Xu, X. Y., Wang, R., Liu, Z. G., Zhou, X. L., & Yang, H. T. (2017). Analysis of phenolic, Vc and antioxidant activity of fruits and leaves of Rosa sterilis D. Shi. Zhiwu Kexue Xuebao, 35(1), 122-127.
62	9,12,15-octadecatrienoic acid	C₁₈H₃₀O₂	278.44	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
63	9,12-octadecadienoic acid	C₁₈H₃₂O₂	280.45	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
64	Chlorogenic acid	C₁₆H₁₈O₉	354.31	Fruit, Leaf	Xie et al., 2017Xie, G. F., Xu, X. Y., Wang, R., Liu, Z. G., Zhou, X. L., & Yang, H. T. (2017). Analysis of phenolic, Vc and antioxidant activity of fruits and leaves of Rosa sterilis D. Shi. Zhiwu Kexue Xuebao, 35(1), 122-127.
65	Ellagic acid glucuronide	C₂₁H₁₆O₁₃	476.35	Fruit	Hou et al., 2020Hou, Z., Yang, H., Zhao, Y., Xu, L., Zhao, L., Wang, Y., & Liao, X. (2020). Chemical characterization and comparison of two chestnut rose cultivars from different regions. Food Chemistry, 323, 126806. http://dx.doi.org/10.1016/j.foodchem.2020.126806. PMid:32330647. http://dx.doi.org/10.1016/j.foodchem.202...

No.	Chemical compound	Formula	Molecular weight (g/mol)	Part of plant	Ref.
66	Procyanidin B1	C₃₀H₂₆O₁₂	579.14	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
67	Procyanidin B2	C₃₀H₂₆O₁₂	579.14	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
68	Procyanidin B3	C₃₀H₂₆O₁₂	579.14	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
69	Fisetinidol-(4α,8)-catechin	C₃₀H₂₆O₁₁	561.14	Fruit	Fu et al., 2020Fu, Y. Y., Liu, J. M., Lu, X. L., Peng, Q. R., Xie, Y. C., & Yang, M. (2020). Research progress on main active components and pharmacological effects of Rosa roxburghii Tratt. Science and Technology of Food Industry, 41(13), 328-335.
70	Rugosin F	C₈₂H₅₆O₅₂	1873.30	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
71	Roxbin B	C₄₁H₂₈O₂₆	936.65	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
72	Roxbin A	C₇₅H₅₀O₄₇	1703.18	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
73	Pedunculagin	C₃₄H₂₄O₂₂	784.54	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
74	Casuarictin	C₄₁H₂₈O₂₆	936.65	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
75	Alnusiin	C₄₁H₂₆O₂₆	934.63	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
76	Stachyurin	C₄₁H₂₈O₂₆	936.65	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
77	Tellimagrandin II	C₄₁H₃₀O₂₆	938.67	Fruit	Yoshida et al., 1987Yoshida, T., Chen, X. M., Hatano, T., Fukushima, M., & Okuda, T. (1987). Tannins and related polyphenols of rosaceous medicinal plants. IV. Roxbins A and B from Rosa roxburghii fruits. Chemical & Pharmaceutical Bulletin, 35(5), 1817-1822. http://dx.doi.org/10.1248/cpb.35.1817. PMid:3664796. http://dx.doi.org/10.1248/cpb.35.1817...
78	Strictinin isomers	C₂₆H₂₀O₁₉	636.43	Fruit	Ma et al., 2020Ma, Y., Wang, Y., Zhang, H., Sun, W., Li, Z., Zhang, F., Zhang, H., Chen, F., Zhang, H., An, J., & He, C. (2020). Antimicrobial mechanism of strictinin isomers extracted from the root of Rosa roxburghii Tratt (Ci Li Gen). Journal of Ethnopharmacology, 250, 112498. http://dx.doi.org/10.1016/j.jep.2019.112498. PMid:31877366. http://dx.doi.org/10.1016/j.jep.2019.112...

name	compose	The molar ratio (%)	molecular weight (Da)	preparation method	Source	Ref.
novel acidic polysaccharide (RTFP-3)	Carbohydrate, Protein, Galacturonic acid, Monosaccharides, Arabinose, Galactose, Glucose, Mannose, XyloseFucose	83.12:1.78:9.47:37.20:34.14:10.02:0.15:0.17:18.30	67200	Dried powder of R. roxburghii fruits was refluxed with 95% ethanol twice at 70 °C for 3 h to remove liposoluble compounds and impurities. The separation and purification of crude RTFP was carried out using a DEAE-Sepharose fast-flow column.	Fruit	Wang et al., 2018b Wang, L., Chen, C., Zhang, B., Huang, Q., Fu, X., & Li, C. (2018b). Structural characterization of a novel acidic polysaccharide from Rosa roxburghii Tratt fruit and its α-glucosidase inhibitory activity. Food & Function, 9(7), 3974-3985. http://dx.doi.org/10.1039/C8FO00561C. PMid:29974117. http://dx.doi.org/10.1039/C8FO00561C...
RRTP-1	Rhamnose, Arabinose, Unknown sugar, Xylose, Mannose, Galactose, Glucose	1.00:16.75:13.37:5.86:11.49:22.73:7.80	3200	After proteins and coloring matter were removed, RRTP-1 was isolated and purified by DEAE-cellulose and Sepharose CL-6B column chromatography from crude polysaccharide and its physicochemical properties were determined by gel permeation chromatography, GC, and IR spectrum.	Fruit	Yang, 2008Yang, J. T. (2008). Isolation and purification, physicochemical properties and biological activity of Rosa roxburghii Tratt polysaccharides (Master’s thesis). Guizhou University, Guiyang.; Yang et al., 2005Yang, J., Chen, F. X., & Liang, G. Y. (2005). Studyies on physicochemical properties and anti-hypoxia activity of polysaccharide RRTP-1 from Rosa roxburghii. Zhongguo Yao Xue Za Zhi, 40(23), 1775-1778.; Yang et al., 2006Yang, J., Yang, F. Y., & Sun, Q. Y. (2006). Study on isolation and neurotrophic activity of ploysaccharides from Rosa roxburghii. Zhongguo Yao Xue Za Zhi, 41(13), 980-982.
RRTP-3	Rhamnose, Arabinose, Unknown sugar, Mannose, Galactose, Glucose	1.00:5.47:1.31:3.02:15.88:1.58	52000	The crude polysaccharide was obtained from the juice of Rosa roxburhhii Tratt by concentration and precipitation with ethanol. After proteins and coloring matter were removed, RRTP-3 was isolated and purified by cellulose and Sepharose CL-6B column chromatography from crude polysaccharide, and its physicochemical properties were determined by gel permeation chromatography, GC and IR spectrum	Fruit	Yang, 2008Yang, J. T. (2008). Isolation and purification, physicochemical properties and biological activity of Rosa roxburghii Tratt polysaccharides (Master’s thesis). Guizhou University, Guiyang.; Yang et al., 2006Yang, J., Yang, F. Y., & Sun, Q. Y. (2006). Study on isolation and neurotrophic activity of ploysaccharides from Rosa roxburghii. Zhongguo Yao Xue Za Zhi, 41(13), 980-982.
Water-soluble polysaccharides (RTFP)	Arabinose, Galactose, Glucose, Mannose, Xylose, Fucose	33.8:37.3: 20.7:1.74: 3.43: 2.95	513020	Water-soluble polysaccharides (RTFP) were extracted from Rosa roxburghii Tratt fruit through the hot water method	Fruit	Wang et al., 2018c Wang, L., Zhang, B., Xiao, J., Huang, Q., Li, C., & Fu, X. (2018c). Physicochemical, functional, and biological properties of water-soluble polysaccharides from Rosa roxburghii Tratt fruit. Food Chemistry, 249, 127-135. http://dx.doi.org/10.1016/j.foodchem.2018.01.011. PMid:29407915. http://dx.doi.org/10.1016/j.foodchem.201...
polysaccharides from RRT fruit (RRTPs)	Mannose, Rhamnose, Glucuronic acid, Galacturonic acid, Glucose, Galactose, Arabinose, Xylose	2.64:5.13:2.71:1.20:6.69:8.01:1.00:1.55	332563, 183963, 11929, 5953	the response surface methodology was utilized to determine optimum conditions for extract-ing the polysaccharides from Rosa roxburghii Tratt fruit (RRTPs) using ultrasonic-assisted extraction	Fruit	Chen & Kan, 2018bChen, G., & Kan, J. (2018b). Ultrasound-assisted extraction, characterization, and antioxidant activity in vitro and in vivo of polysaccharides from chestnut rose (Rosa roxburghii tratt) fruit. Journal of Food Science and Technology, 55(3), 1083-1092. http://dx.doi.org/10.1007/s13197-017-3023-8. PMid:29487451. http://dx.doi.org/10.1007/s13197-017-302...
RSPs-40	Arabinose, Galactose, Glucose, Fructose, Galactouronic acid	0.24:0.37:3.22:0.27:1.44	228298	Hot water extraction and fractional alcohol precipitation technology	Fruit	Chen et al., 2019aChen, Q., Li, C., Huang, T., Fu, X., & Jia, Q. (2019a). Physicochemical characterization, in vitro antioxidant and α-glucosidase inhibitory activity of polysaccharides from Rosa sterilis fruit. Modern Food Science and Technology, 35(11), 114-119.
RSPs-60	Arabinose, Galactose, Glucose, Galactouronic acid	1.58:2.06:2.37:1.69	124144	Hot water extraction and fractional alcohol precipitation technology	Fruit	Chen et al., 2019aChen, Q., Li, C., Huang, T., Fu, X., & Jia, Q. (2019a). Physicochemical characterization, in vitro antioxidant and α-glucosidase inhibitory activity of polysaccharides from Rosa sterilis fruit. Modern Food Science and Technology, 35(11), 114-119.
RRT leaves (RLP-1.2)	galacturonic acid, glucose, galactose, arabinose	1.00:18.98:4.21:1.31	40500	Response surface methodology, DEAE-52 cellulose column, and SepharoseCL-6B column chromatography were used to purify RLP, and RLP-1.2 and RLP-2.1 were obtained.	Leaves	Wu et al., 2020aWu, H., Li, M., Yang, X., Wei, Q., Sun, L., Zhao, J., & Shang, H. (2020a). Extraction optimization, physicochemical properties and antioxidant and hypoglycemic activities of polysaccharides from roxburgh rose (Rosa roxburghii Tratt.) leaves. International Journal of Biological Macromolecules, 165(Pt A), 517-529. http://dx.doi.org/10.1016/j.ijbiomac.2020.09.198. PMid:33002536. http://dx.doi.org/10.1016/j.ijbiomac.202...
RRT) leaves (RLP-2.1)	galacturonic acid, glucose, galactose, arabinose	1.00:6.30:2.18:0.53	29400	Response surface methodology, DEAE-52 cellulose column, and SepharoseCL-6B column chromatography were used to purify RLP, and RLP-1.2 and RLP-2.1 were obtained.	Leaves	Wu et al., 2020aWu, H., Li, M., Yang, X., Wei, Q., Sun, L., Zhao, J., & Shang, H. (2020a). Extraction optimization, physicochemical properties and antioxidant and hypoglycemic activities of polysaccharides from roxburgh rose (Rosa roxburghii Tratt.) leaves. International Journal of Biological Macromolecules, 165(Pt A), 517-529. http://dx.doi.org/10.1016/j.ijbiomac.2020.09.198. PMid:33002536. http://dx.doi.org/10.1016/j.ijbiomac.202...
PR-1	Mannose, Ribose, Rhamnose, Glucosamine Hydrochloride, Glucuronic acid, Galacturonic acid, Glucose, Galactose, Arabinose, Fucose	2.1:0.54: 2.1: 0.26:1.5: 22.7:24.0: 26.4:19.6:0.89	6200 to 7400	An extraction assay applying microwave-assisted enzymatic treatment for polysaccharides in Rosa roxburghii were developed using response surface methodology.	Fruit	Wang et al., 2018aWang, H., Li, Y., Ren, Z., Cong, Z., Chen, M., Shi, L., Han, X., & Pei, J. (2018a). Optimization of the microwave-assisted enzymatic extraction of Rosa roxburghii Tratt polysaccharides using response surface methodology and its antioxidant and α-D-glucosidase inhibitory activity. International Journal of Biological Macromolecules, 112, 473-482. http://dx.doi.org/10.1016/j.ijbiomac.2018.02.003. PMid:29412175. http://dx.doi.org/10.1016/j.ijbiomac.201...
RRTFP-2	Rhamnose, Arabinose, Mannose, Glucose, Galactose,	1.0:6.5:1.1:1.2:16.1	74330	The crude polysaccharide of Rosa roxburghii dried fruit was purified by ion exchange and molecular gel column chromatography to obtain RRTFP-2.	Fruit	Xie et al., 2022Xie, Jing, H. D., Li, Y. X., Lilang, Yu, W., Qiji, L., Zhongsheng, L., & Juan, Y. (2022). Structure analysis and NGF-Like neurotrophic activity of polysaccharides RRTFP-2 from Rosa roxburghii Tratt. Food Science and Technology, 47(4), 224-230.

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Chemical constituents and bioactivities of Rosa roxburghii: a systematic review

Abstract