In the present study, we describe the synthesis of alkylseleno carbohydrates with different sugar scaffolds and the evaluation of their antioxidant activity profile. A compound possessing a C8 alkyl chain presented the best results in the free radical scavenging activity.
organoselenium; organochalcogens; antioxidant; selenocarbohydrates
| μM | Scavenging ABTS / % | μM | Scavenging DPPH / % | μM | FRAP (absorbance) |
|---|---|---|---|---|---|
| 10 | 2.27 ± 1.79 | 10 | 0.03 ± 0.05 | 10 | 0.19 ± 0.04 |
| 50 | 13.60 ± 1.57c b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). | 50 | 0.26 ± 0.45 | 50 | 0.22 ± 0.03 |
| 100 | 25.99 ± 1.61c b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). | 100 | 0.13 ± 0.22 | 100 | 0.26 ± 0.02 |
| 500 | 81.69 ± 0.90c b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). | 500 | 5.49 ± 3.40b b p < 0.01; | 500 | 0.57 ± 0.08c b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). |
| IC50 | 210 | - | - | - | - |
| μM | FRAP (absorbance) |
|---|---|
| 10 | 0.19 ± 0.06 |
| 50 | 0.19 ± 0.04 |
| 100 | 0.20 ± 0.03 |
| 500 | 0.65 ± 0.07b b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). |
| μM | Scavenging ABTS / % |
|---|---|
| 10 | 3.47 ± 0.47 |
| 50 | 4.24 ± 3.93 |
| 100 | 7.64 ± 4.90 |
| 500 | 31.77 ± 19.26b b p < 0.01 as compared to the respective control sample (one way ANOVA/Newman-Keuls). |
| μM | Scavenging ABTS / % | μM | FRAP (absorbance) |
|---|---|---|---|
| 10 | 3.04 ± 4.10 | 10 | 0.20 ± 0.04 |
| 50 | 12.47 ± 3.74 | 50 | 0.20 ± 0.03 |
| 100 | 24.90 ± 5.81c c p < 0.001 as compared to the respective control sample (one way ANOVA/Newman-Keuls). | 100 | 0.23 ± 0.06 |
| 500 | 21.01 ± 7.87b b p < 0.01; | 500 | 0.54 ± 0.07c c p < 0.001 as compared to the respective control sample (one way ANOVA/Newman-Keuls). |
