The synthesis of title compounds 3a-g, from arylamidoximes 1a-g and succinic anhydride in high yields is described. 1,2,4-Oxadiazoles 3a-f were also obtained by carrying out the reaction in a domestic microwave oven. Preliminary pharmacological evaluations demonstrated that 3b-e possess analgesic properties. Ab initio molecular orbital calculations of the type STO-3G have been performed for compounds 3a, 4a, 5a and 6a.
arylamidoximes; bis-1,2,4-oxadiazoles; diaryl-1,2,4-oxadiazoles; ab-initio sto-3g calculations
