Investigation on Ruthenium(II) Bipyridine/Ag<sup>III</sup> Complexes Chemiluminescence System and Its Application for Sensitive Norfloxacin and Ofloxacin Detection

Liu, Jinjin; Ma, Ling; Zhao, Tangjuan; Yang, Kaijie; Shi, Hongmei; Kang, Weijun; Ma, Li

doi:10.21577/0103-5053.20180223

Acessibilidade / Reportar erro

Brasil

Journal of the Brazilian Chemical Society

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Article • J. Braz. Chem. Soc. 30 (4) • Apr 2019 • https://doi.org/10.21577/0103-5053.20180223 copy

Investigation on Ruthenium(II) Bipyridine/Ag^III Complexes Chemiluminescence System and Its Application for Sensitive Norfloxacin and Ofloxacin Detection

Authorship SCIMAGO INSTITUTIONS RANKINGS

The reaction mechanism of Ag^III complex ([Ag(HIO₆)₂]^5–) with ruthenium(II) bipyridine (Ru(bpy)₃²⁺) in acid medium was investigated. A novel flow injection chemiluminescence (CL) analysis method was developed for the detection of norfloxacin (NFLX) and ofloxacin (OFLX) in commercial drug, milk and human urine samples based on Ag^III-ruthenium(II) bipyridine in acidic solution. Under optimal conditions, CL intensities were proportional to drug concentrations in the range of 1.6 × 10^-9 to 8 × 10^-6 g mL^-1 for NFLX and 1.0 × 10^-9 to 4 × 10^-6 g mL^-1 for OFLX. The detection limit was 1.0 × 10^-9 g mL^-1 for NFLX and 0.8 × 10^-9 g mL^-1 for OFLX. On the basis of the CL, UV and fluorescence spectra, possible reaction mechanisms were proposed.

Keywords:
Ag^III; ruthenium(II) bipyridine; CL; mechanism

Method		Linear range	Detection limit / (g mL^-1)	Reference
Ru(bpy)₃²⁺-Ce^IV	ofloxacin	0.003-0.7 µg mL^-1	1.1 × 10^-10	²2 Aly, F. A.; Al-Tamimi, S. A.; Alwarthan, A. A.; Talanta 2001, 53, 885.
	norfloxacin	0.05-7.0 µg mL^-1	1.75 × 10^-9
Ce^IV-Na₂SO₃	ofloxacin	0.04-4 µg mL^-1	1.6 × 10^-8	⁷7 Rao, Y.; Tong, Y.; Zhang, X. R.; Luo, G. A.; Baeyens, W. R. G.; Anal. Chim. Acta 2000, 416, 227.
Ce^IV-Na₂S₂O₄	ofloxacin	2.0 × 10^-8-6.0 × 10^-6 g mL^-1	7 × 10^-9	⁸8 Sun, H. W.; Li, L. Q.; Chen, X. Y.; Anal. Sci. 2006, 22, 1145.
	norfloxacin	1.0 × 10^-8-6.0 × 10^-5 g mL^-1	6 × 10^-9
Ce^IV-Na₂SO₃-nano Au	norfloxacin	7.9 × 10^-7-1.9 × 10^-5 g mL^-1	2.61 × 10^-8	⁵5 Yu, X. J.; Bao, J. F.; J. Lumin. 2009, 129, 973.
Ag^III-H₂SO₄	norfloxacin	1.34 × 10^-8-5.44 × 10^-6 g mL^-1	3.10 × 10^-9	¹⁰10 Sun, H. W.; Chen, P. Y.; Wang, F.; Spectrochim. Acta, Part A 2009, 74, 819.
Ru(bpy)₃²⁺-Ag^III-H₂SO₄	ofloxacin	1.0 × 10^-9-4 × 10^-6 g mL^-1	0.8 × 10^-9	this method
	norfloxacin	1.6 × 10^-9-8 × 10^-6 g mL^-1	1 × 10^-9

Analyte	Labeled value / (mg per capsule)	Determination value		Added / mg	Found / mg	Recovery / %	RSD (n = 3) / %
Analyte	Labeled value / (mg per capsule)	This method	UV	Added / mg	Found / mg	Recovery / %	RSD (n = 3) / %
Norfloxacin	100	97.0	99.2	50	51.1	102.6	1.5
				100	99.9	97.4	1.04
				200	206	109.5	1.12
Ofloxacin	100	91.0	92.2	50	52.8	105.6	0.96
				100	102.4	102.4	0.39
				200	198	99.0	0.87

Sample/analyte	Background	Added / (µg mL^-1)	Found / (µg mL^-1)	Recovery / %	RSD (n = 3) / %
Milk/norfloxacin	0	0.1	0.096	98.51	3.53
		0.2	0.202	100.89	3.58
		0.5	0.526	105.17	3.17
Urine/norfloxacin	6.85	2.5	9.28	97.2	0.72
		5.0	12.04	103.8	0.59
		10.0	16.83	99.98	0.55
Urine/ofloxacin	4.52	2.5	7.13	104.4	0.35
		5.0	9.80	105.6	0.46
		10.0	14.89	103.7	0.53

Sociedade Brasileira de Química Instituto de Química - UNICAMP, Caixa Postal 6154, 13083-970 Campinas SP - Brazil, Tel./FAX.: +55 19 3521-3151 - São Paulo - SP - Brazil
E-mail: office@jbcs.sbq.org.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] *e-mail: mali@hebmu.edu.cn

Brasil

Brasil

Investigation on Ruthenium(II) Bipyridine/AgIII Complexes Chemiluminescence System and Its Application for Sensitive Norfloxacin and Ofloxacin Detection

Investigation on Ruthenium(II) Bipyridine/Ag^III Complexes Chemiluminescence System and Its Application for Sensitive Norfloxacin and Ofloxacin Detection