Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioactivities and total synthesis. An overview of the research on marine natural products by Brazilian researchers is also discussed, as well as perspectives for the development of the chemistry of marine natural products in Brazil.

Keywords:
marine natural products; marine sponges; marine bacteria; marine fungi; marine alkaloids; marine polyketides

Authorship

Laura P. Ióca

Instituto de Química de São Carlos, Universidade de São Paulo, CP 780, 13560-970 São Carlos-SP, BrazilUniversidade de São PauloBrazilSão Carlos, SP, BrazilInstituto de Química de São Carlos, Universidade de São Paulo, CP 780, 13560-970 São Carlos-SP, Brazil

Laura P. Ióca graduated in Physical and Biomolecular Sciences at the Instituto de Física de São Carlos, Universidade de São Paulo, in 2013. In 2012, she was a visiting student at the Scripps Institution of Oceanography under the supervision of Paul R. Jensen. She got an MSc Degree and is currently a PhD student at the Instituto de Química de São Carlos, Universidade de São Paulo, under the supervision of Dr Roberto G. S. Berlinck. Her research interests include the investigation of metabolism and biosynthesis of secondary metabolites from microorganisms.

Karen J. Nicacio

Karen J. Nicacio graduated in Chemistry at State University of Santa Cruz in 2010. In 2012 she completed an MSc (2012) and a PhD (2017) at the Instituto de Química de São Carlos, Universidade de São Paulo, under the supervision of Dr Roberto G. S. Berlinck. She is currently a research associate at Dr Berlinck's lab. Her research interests include the chemistry and biology of marine microbial secondary metabolites.

Roberto G. S. Berlinck ^**e-mail: rgsberlinck@iqsc.usp.br

Roberto G. S. Berlinck joined the Instituto de Química de São Carlos, Universidade de São Paulo in 1993. He was appointed as associate professor in 2001 and as full professor in 2010. He was a visiting scholar at Professor Raymond J. Andersen group (University of British Columbia) and at Professor David H. Sherman group (University of Michigan). His research interests include the isolation, identification, biological activities, synthesis and biosynthesis of natural products from marine invertebrates and microorganisms.

*e-mail: rgsberlinck@iqsc.usp.br

Laura P. Ióca graduated in Physical and Biomolecular Sciences at the Instituto de Física de São Carlos, Universidade de São Paulo, in 2013. In 2012, she was a visiting student at the Scripps Institution of Oceanography under the supervision of Paul R. Jensen. She got an MSc Degree and is currently a PhD student at the Instituto de Química de São Carlos, Universidade de São Paulo, under the supervision of Dr Roberto G. S. Berlinck. Her research interests include the investigation of metabolism and biosynthesis of secondary metabolites from microorganisms.

Karen J. Nicacio graduated in Chemistry at State University of Santa Cruz in 2010. In 2012 she completed an MSc (2012) and a PhD (2017) at the Instituto de Química de São Carlos, Universidade de São Paulo, under the supervision of Dr Roberto G. S. Berlinck. She is currently a research associate at Dr Berlinck's lab. Her research interests include the chemistry and biology of marine microbial secondary metabolites.

Roberto G. S. Berlinck joined the Instituto de Química de São Carlos, Universidade de São Paulo in 1993. He was appointed as associate professor in 2001 and as full professor in 2010. He was a visiting scholar at Professor Raymond J. Andersen group (University of British Columbia) and at Professor David H. Sherman group (University of Michigan). His research interests include the isolation, identification, biological activities, synthesis and biosynthesis of natural products from marine invertebrates and microorganisms.

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