A convenient and efficient protocol for the one pot synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones catalyzed by ionic liquids under ultrasound irradiation

Abstract

Derivatives of 3,4-dihydropyrimidin-2-(1H)-ones were synthesized in excellent yields in short reaction time by one pot, three component reaction of aldehydes, ethyl acetoacetate and urea (or thiourea) in room temperature ionic liquids (RTILs) under ultrasound irradiation without any added catalyst. A plausible mechanistic pathway has been postulated based on the catalytic role of the ionic liquid in promoting the reaction. The ionic liquids could be recycled at least six times with retention of their activity

one pot synthesis; 3,4-dihydropyrimidin-2-(1H)-ones; ionic liquid; ultrasound