Smart Films Produced by Electrospinning of Poly(butylene-adipate-<i>co</i>-terephthalate)/poly-(ε-caprolactone) for Controlled Delivery of Ibuprofen

Hardt, Janice C.; Fraga, Gabriel N.; Medeiros, Alessandra R.; Rossin, Ariane R. S.; Caetano, Josiane; Leite, Matheus C. O.; Fonseca, Bruno V. L. da; Vilsinski, Bruno H.; Dragunski, Douglas C.

doi:10.21577/0103-5053.20240004

person Janice C. Hardt

writing original draft · data curation

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, Brazil

person Gabriel N. Fraga

investigation · validation

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, BrazilschoolDepartamento de Química, Universidade Estadual de Maringá, 87020-900 Maringá-PR, Brazil

person Alessandra R. Medeiros

formal analysis · data curation

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, BrazilschoolDepartamento de Química, Universidade Estadual de Maringá, 87020-900 Maringá-PR, Brazil

0000-0003-2907-337X

person Ariane R. S. Rossin

writing original draft · writing-review

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, BrazilschoolDepartamento de Química, Universidade Estadual de Maringá, 87020-900 Maringá-PR, Brazil

person Josiane Caetano

investigation · project administration

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, Brazil

person Matheus C. O. Leite

validation · data curation

schoolGrupo de Materiais Biopoliméricos e Compósitos (GMBC), Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora-MG, Brazil

person Bruno V. L. da Fonseca

validation · conceptualization

schoolGrupo de Materiais Biopoliméricos e Compósitos (GMBC), Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora-MG, Brazil

person Bruno H. Vilsinski *

writing original draft · project administration · writing-review

schoolGrupo de Materiais Biopoliméricos e Compósitos (GMBC), Universidade Federal de Juiz de Fora, 36036-900 Juiz de Fora-MG, Brazil

0000-0002-9050-5760

person Douglas C. Dragunski *

project administration · visualization · resources

schoolGrupo Interdisciplinar de Fotoquímica e Eletroquímica Ambiental, Centro de Engenharias e Ciências Exatas, Universidade Estadual do Oeste do Paraná, 85903-000 Toledo-PR, BrazilschoolDepartamento de Química, Universidade Estadual de Maringá, 87020-900 Maringá-PR, Brazil

0000-0001-7870-097X

person* e-mail:
bruno.vilsinski@ufjf.br;
dcdragunski@gmail.com

Editor handled this article: Fernando C. Giacomelli (Associate)

Solution	Conductivity / (μs cm^-1)	Relative viscosity
PBAT/PCL	1.17 ± 0.023	4.044 ± 0.095
PBAT/PCL/IBU-20	1.011 ± 0.0066	2.983 ± 0.023
PBAT/PCL/IBU-30	0.828 ± 0.016	2.985 ± 0.045

Sample	Peak 1		Peak 2		Peak 3		Peak 4
Sample	T_melting / °C	ΔH_m / (J g^-1)	T_melting / °C	ΔH_m / (J g^-1)	T_melting / °C	ΔH_m / (J g^-1)	T_{crystallization} / °C	ΔHrecrystalization / (J g^-1)
PBAT/PCL	55	21.6	–	–	143	11.5	75	–17.7
PBAT/PCL/IBU-20	54	37.0	–	–	114	7.6	71	–16.1
PBAT/PCL/IBU-30	49	19.4	59	2.3	129	5.5	76	–6.9

Sample	Crystallinity peak 1 / %	Crystallinity peak 3 / %
PBAT/PCL	28.1	25.6
PBAT/PCL/IBU-20	38.0	20.8
PBAT/PCL/IBU-30	18.9	10.9

time / s	Contact angle / degree
time / s	PBAT/PCL	PBAT/PCL/IBU-20	PBAT/PCL/IBU-30
0	110	82	101
120	108	89	95
240	107	61	92
360	106	55	91
480	106	51	91

No.	Model	Equation
1	zero-order⁴³	(2) $F = k_{0} t$
2	first-order⁴⁴	(3) $F = 100 \times (1 - e^{- k_{1} \times t})$
3	Higuchi⁴⁵	(4) $F = k_{H} \times t^{\frac{1}{2}}$
4	Korsmeyer-Peppas⁴⁶	(5) $F = k_{HP} \times t^{n}$
5	Hixson-Crowell⁴⁷	(6) $F = 100 \times [1 - {(1 - k_{HC} \times t)}^{3}]$
6	Hopfenberg⁴⁸	(7) $F = 100 \times [1 - {(1 - k_{HB} \times t)}^{n}]$
7	Baker-Londsale⁴⁹	(8) $\frac{3}{2} [1 - {(- \frac{F}{100})}^{(\frac{2}{3})}] - \frac{F}{100} = k_{BL} \times t$
8	Peppas-Sahlin⁵⁰	(9) $F = k_{1} \times t^{m} + k_{2} \times t^{2m}$
9	quadratic⁵¹	(10) $F = 100 \times (k_{1 q} \times t^{2} + k_{2} \times t)$
10	Weibull⁵¹	(11) $F = 100 \times [1 - e^{- (\frac{- {(t - T_{i})}^{β}}{α})}]$
11	logistic⁴⁸	(12) $F = F \frac{e^{α_{1} + β_{1} \times logt}}{1 + e^{α_{1} + β_{1} \times logt} \max}$
12	Gompertz⁵²	(13) $F = 100 \times e^{- α_{G} \times e^{- β_{G} \times logt}}$
13	Probit⁵²	(14) $F = 100 \times ϕ [α_{P} + β_{P} \times logt]$

No.	PBAT/PCL/IBU-20				PBAT/PCL/IBU-30
No.	R	R²_adjusted	AIC	MSC	R	R²_adjusted	AIC	MSC
1	0.8946	0.6982	122.4827	0.8317	0.8946	0.6982	122.4827	0.8377
2	0.9777	0.9379	99.1857	2.3908	0.9750	0.9231	96.5913	2.2590
3	0.9672	0.9095	105.8293	1.9479	0.9724	0.9101	100.6593	1.9878
4	0.9329	0.2321	123.9153	0.7422	0.9322	0.7614	115.0649	1.0274
5	0.9649	0.8961	106.8625	1.8790	0.9641	0.8818	102.7245	1.8501
6	0.9701	0.9056	106.5677	1.8987	0.9654	0.8919	102.6904	1.8524
7	0.9780	0.8865	108.8024	1.7497	0.9795	0.8825	103.5942	1.7921
8	0.9707	0.8999	109.0456	1.7335	0.9723	0.9109	102.2305	1.8830
9	0.9871	0.9687	87.0104	3.2025	0.9879	0.9687	83.9381	3.1025
10	0.9698	0.8976	103.8963	2.0768	0.9717	0.9187	100.9320	1.9696
11	0.9838	0.9517	89.3786	3.0446	0.9851	0.9649	87.4208	2.8703
12	0.9954	0.9888	73.6122	4.0957	0.9960	0.9913	65.7426	4.3155
13	0.9889	0.9705	84.3001	3.3832	0.9899	0.9772	80.7771	3.3132

Sample	Peak 1		Peak 2		Peak 3		Peak 4
Sample	T_melting / °C	ΔH_m / (J g^-1)	T_melting / °C	ΔH_m / (J g^-1)	T_melting / °C	ΔH_m / (J g^-1)	T_{crystallization} / °C	ΔH_{recrystalization} (J g^-1)
PBAT/PCL	55	21.6	–	–	143	11.5	75	–17.7
PBAT/PCL/IBU-20	59	22.9	–	–	124	9.3	82	–25.9
PBAT/PCL/IBU-30	57	20.1	75	1.8	93	3.0	80	–17.4

Sample	Crystallinity peak 1 / %	Crystallinity peak 3 / %
PBAT/PCL	28.1	25.6
PBAT/PCL/IBU-20 released	35.0	30.8
PBAT/PCL/IBU-30 released	26.9	16.8

[TFN1] PBAT: poly(butylene-adipate-co-terephthalate); PCL: poly-(ε-caprolactone); IBU: ibuprofen.

Smart Films Produced by Electrospinning of Poly(butylene-adipate-co-terephthalate)/poly-(ε-caprolactone) for Controlled Delivery of Ibuprofen

Abstract