Moore et al., 20161919 Moore TA, Schmid KK, Anderson-Berry A, Berger AM. Lung disease, oxidative stress, and oxygen requirements in preterm infants. Biol Res Nurs. 2016;18:322-30. United States |
Prospective |
31 PTN |
Cord blood and urine |
8-OHdG |
CLD IVH BPD ROP |
CLD was associated with lower levels of 8-OHdG. There were no significant differences regarding IVH, BPD, and ROP incidences. |
Perrone et al., 20161313 Perrone S, Tataranno ML, Negro S, Longini M, Toti MS, Alagna MG, et al. Placental histological examination and the relationship with oxidative stress in preterm infants. Placenta. 2016;46:72-8. Italy |
Cohort |
120 PTN |
Cord blood |
IsoPs NPBI AOPP |
IUGR |
Placental injuries (inflammation or impaired perfusion) were associated with elevated OS levels. PTN with vascular perfusion lesions had higher levels of AOPP, low GA, and the IUGR. |
Dietze et al., 20162020 Dietze TR, Rosea FF, Moore TA. Maternal variables associated with physiologic stress and perinatal complications in preterm infants. J Neonatal Perinatal Med. 2016;9:271-7. United States |
Prospective |
31 PTN |
Cord blood and saliva |
Cortisol |
NEC IVH BPD ROP |
The higher the GA at the beginning of prenatal care, the lower cord blood cortisol and tended to have a higher risk of NEC. In salivary cortisol, NB whose mothers smoked had a higher risk of IVH. |
Ghany et al., 20161010 Ghany EA, Elhamed WA, Ali AA, Youness ER, Hussein JS. Antioxidant profiles and markers of oxidative stress in preterm neonates. Paediatr Int Child Health. 2016;36:134-40. Egypt |
Case-control study |
200 NB 100 PTN 100 FT NB |
Cord blood and venous blood |
MDA; TAC Catalase Vitamin A Vitamin E |
NEC BPD IVH |
Positive relationship between reduced antioxidant levels at birth and the risk of neonatal morbidities, including BPD, IVH, NEC. |
Bandyopadhyay et al., 201788 Bandyopadhyay T, Bhatia BD, Khanna HD. A study of oxidative stress in neonates delivered through meconium-stained amniotic fluid. Eur J Pediatr. 2017;176:317-25. India |
Transversal |
109 NB 27 PTN 82 FT NB |
Cord blood |
MDA 8-OHdG |
IUGR |
Term NB and late PTN with IUGR had higher levels of MDA and 8-OHdG compared to infants suitable for GA through meconium-stained amniotic fluid. |
Norishadkam et al., 201744 Norishadkam M, Andishmand S, Zavar reza J, Sakhvidi MJ, Hachesoo VR. Oxidative stress and dna damage in the cord blood of preterm infants. Mutat Res. 2017;824:20-4. Iran |
Case-control study |
50 NB 25 PTN 25 FT NB |
Cord blood |
MDA Catalase SOD TAC |
DNA damage |
There was no significant association between MDA, SOD, TAC, catalase, and early DNA damage in cord blood plasma for PTN. |
Ozalkaya et al., 20172121 Ozalkaya E, Karatekin G, Topçuoglu S, Karatepe HO, Taner Hafızoglu T, Baran P, et al. Neonatology oxidative status in preterm infants with premature preterm rupture of membranes and fetal inflammatuar response syndrome. Pediatr Neonatol. 2017;58:437-41. Turkey |
Prospective |
51 PTN |
Cord blood |
TAC PON-1 TOS OSI |
FIRS RDS IVH BPD ROP Sepsis |
Higher levels of TOS were associated with NB with PPROM; Higher PON-1 was associated with higher risk of PPROM, FIRS or both. NB with PPROM and FIRS had higher incidence of RDS. NB with FIRS had higher mortality. |
Bharadwaj et al., 201733 Bharadwaj SK, Bhat BV, Vickneswaran V, Adhisivam B, Bobby Z, Habeebullah S. Oxidative stress, antioxidant status and neurodevelopmental outcome in neonates born to pre-eclamptic mothers. Indian J Pediatr. 2018;85:351-7. India |
Cohort |
143 NB 71 w/ GA >35 e 72 w/ GA >39 |
Maternal blood and cord blood |
Protein carbonyls MDA TAC |
Neurologic deseases IUGR Sepsis |
OS increases in NB and mothers with PE. Decreased maternal TAC is associated with negative neuromotor results. Maternal TAC during PE is useful to predict poor motor development at the corrected age of one year. |
Coutinho et al., 20182222 Coutinho FG, Diniz EM, K Ingrid, Cianciarullo MA, Santos NR. Assessment of oxidative damage and enzymatic antioxidant system activity on the umbilical cord blood and saliva from preterm newborns with risk factors for early-onset neonatal sepsis. Rev Assoc Med Bras (1992). 2018;64:888-95. Brazil |
Transversal |
21 PTN |
Cord blood, saliva, and urine |
MDA SOD GPx Catalase |
Sepsis |
GPx in cord blood can be a diagnostic tool for suspicion of early-onset neonatal sepsis in PTNs of mothers with risk factors for sepsis. |
Armann et al., 20182323 Arman D, Ercin S, Topcuoğlu S, Kaya A, Yavuz T, Karatekin G, et al. The association between oxidative stress and cardiac functions in infants born to preeclamptic mothers. Am J Perinatol. 2019;36:1205-10. Turkey |
Case-control study |
80 PTN |
Cord blood |
TAC TOS OSI |
Cardiac functions |
TAC, TOS, and OSI were significantly higher for NB of mothers with PE. Echocardiographic parameters are not affected by the oxidant state. |
Elkabany et al., 20191212 Elkabany ZA, El-Farrash RA, Shinkar DM, Ismail EA, Nada AS, Farag AS, et al. Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity. Pediatr Res. Egypt |
Prospective Case-control study |
40 PTN |
Cord blood |
MDA; AOPP 8-OHdG TAC Copper; Zinc |
RDS |
AOPPs and 8-OHdG can be used as serum biomarkers for OS among NBs with RDS to monitor disease progression. |
Dekker et al., 2019 Netherlands2424 Dekker J, Martherus T, Lopriore E, Giera M, McGillick EV, Hutten J, et al. The effect of initial high vs. low fio2 on breathing effort in preterm infants at birth: a randomized controlled trial. Front Pediatr. 2019;7:504.
|
Clinical trial |
52 PTN |
Cord blood and venous blood |
8iPGF2α |
Grade III IVH |
8iPGF2α did not differ among groups. There were also no differences regarding intubation, the incidence of grade III IVH, or death before hospital discharge. |
Silva et al., 2019 Brazil2525 Silva AB, Medeiros JF, Lima MS, Mata AM, Andrade ED, Bezerra DS, et al. Intrauterine growth and the vitamin E status of full-term and preterm newborns. Rev Paul Pediatr. 2019;37:291-6.
|
Transversal |
140 NB 54 PTN and 76 FT NB |
Cord blood |
Vitamin E |
IUGR |
IUGR was more frequent in PTB; most of the infants had low vitamin E levels. |
Stefanov et al., 202099 Stefanov G, Briyal S, Pais G, Puppala B, Gulati A. Relationship between oxidative stress markers and endothelin-1 levels in newborns of different gestational ages. Front Pediatr. 2020;8:279. United States |
Prospective Pilot study |
63 NB 50 PTN and 13 FT NB |
Cord blood and venous blood |
MDA Glutathione |
Endothelial dysfunction |
MDA was higher in cord blood than at 24 hours of life, regardless of GA. PTN had higher ET-1 levels in cord blood than 24 hours of life, but overall, ET-1 had no significant association with OS. |
Liu et al., 2020 China2626 Liu L, Zheng B, Jiang Z, Wu S, Jin Q, Lin P, et al. Elevated cord blood oxidative stress biomarkers negatively affect neonatal outcomes of mothers with severe preeclampsia: a case-control study. BMC Pregnancy Childbirth. 2020;1:1-19.
|
Case-control study |
816 NB 182 PTN 634 FT NB |
Cord blood |
MDA SOD ROSs |
Morbidity and mortality |
Higher levels of MDA and ROSs are associated with lower Apgar scores; NICU admission and ventilation, i.e., are significantly associated with higher morbidity and mortality. |
Pajai e Bezalwar 202055 Pajai SS, Bezalwar AP. Oxidative stress in preterm neonates: an analysis of oxidative stress biomarkers and antioxidant profiles. J Clin Diagn Res. 2020;14:CC01-3. India |
Observational Analytic |
45 PTN |
Cord blood |
MDA Nitrates Vitamin C Vitamin E |
Morbidity and mortality |
PTN shows higher MDA and nitrates levels and reduced levels of vitamins C and E, especially in males, indicating increased morbidity and mortality. |
Agrawal et al., 2021 Índia2727 Agrawal G, Dutta S, Prasad R, Dogra MR. Fetal oxidative stress, micronutrient deficiency and risk of retinopathy of prematurity: a nested case-control study. Eur J Pediatr. 2021; 180:1487-96.
|
Nested case-control |
189 PTN |
Cord blood and venous blood (both from NB and mother) |
MDA Copper Zinc Vitamin A |
ROP |
MDA and vitamin A in umbilical cord plasma were independent predictive variables of ROP. |
Coviello et al., 2021 Netherlands2828 Coviello C, Perrone S, Buonocore G, Negro S, Longini M, Dani C, et al. Isoprostanes as biomarker for white matter injury in extremely preterm infants. Front Pediatr. 2021; 8:618622.
|
Prospective observational study |
44 PTN |
Cord blood and plasma |
F2-isoprostanes |
White matter injury |
Early verification of plasma IsoPs can help discriminate abnormal WMI scores at term-equivalent age; and represents an early biomarker for identifying PTN at risk of brain injury. |