Psychoneuroimmunologic Correlates in a Group of Men who Have Sex with Men with Risky Sexual Behaviors

Restrepo, Jorge Emiro; Giraldo, Ana Claudia Ossa; Gutierrez, Luis Felipe Higuita; Zapata, Wildeman; Montoya, Gina Paula Cuartas

doi:10.1590/0102.3772e39204.en

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Behavioral Sciences • Psic.: Teor. e Pesq. 39 • 2023 • https://doi.org/10.1590/0102.3772e39204.en copy

Psychoneuroimmunologic Correlates in a Group of Men who Have Sex with Men with Risky Sexual Behaviors

Os Correlatos Psiconeuroimunológicos em um Grupo de Homens que Fazem Sexo com Homens com Comportamentos Sexuais de Risco

Authorship SCIMAGO INSTITUTIONS RANKINGS

ABSTRACT

This work aims to know what correlations can be found among psychological, neuropsychological, neurobiological, and immunological measures in a group of men who have sex with men negative for anti-HIV-1/2 antibodies which have sexual risk behaviors. Statistically significant correlations were found among certain behavioral, emotional, personality, neurobiological, and immunological variables. The circuit of interactions among depression, stress, neuroticism, and conscientiousness stands out, which could indirectly explain risky sexual behavior. In summary, there is a relationship between personality characteristics, mood disorders, risk behaviors, and an activated T cell profile.

KEYWORDS:
psychoneuroimmunology; HIV; mood disorders; risky sexual behavior; personality traits

	Me (IQR)
Age (years)	26(22-29)
Sexual relations (last three months)	14(5-30)
Different sexual partners (last three months)	4(2-25)
Unprotected sexual intercourse (last three months)	6(1-10)
	n (%)
Schooling
Postgraduate	1(3.3)
Undergraduate	16(53.3)
Baccalaureate	4(13.3)
Technical	4(13.3)
Technological	5(16.7)
Marital Status
Single	28(93.3)
Unmarried	2(6.7)
Gender Identity
Male	29(96.7)
Queer	1(3.3)
Sexual orientation
Gay/Homosexual	27(90)
Bisexual	3(10)
Have you had a partner with HIV/AIDS?
Yes	15(50)
No	15(50)
Do you use condoms with your casual partners?
Always	12(40)
Sometimes	16(53.3)
Never	2(6.7)
Do you use hallucinogens during sex?
Yes	19(63.3)
No	11(36.7)
Have you ever had STIs?
Yes	16(53.3)
No	14(46.7)
Casual sex in saunas, bathhouses or clubs?
Yes	14(46.7)
No	16(53.3)
Transactional sex?
Yes	1(3.3)
No	29(96.7)

	Low	Normal	High	NA^*
Personality
Neuroticism	16.7%	43.3%	36.7%	3.3%
Extraversion	20%	30%	46.7%	3.3%
Openness to experience	0%	40%	60%
Agreeableness	53.3%	36%	6.7%	3.3%
Conscientiousness	7%	76.7%	13%	3.3%
Mood
Depression		60%	30%	10%
Anxiety		33.3%	66.7%
Stress		46.7%	50%	3.3%
Neurotransmitters
Tryptophan		93.3%		6.7%
Adrenaline		83.3%		16.7%
Noradrenaline		63.3%	20%	16.7%
Dopamine		83.3%		16.7%
Serotonin	3.3%	80%	13.3%
Hormone
Cortisol		96.7%		3.3%
Neuropsychological
Executive functioning	30%	70%
Memory	36.7%	63.3%
Attention	36.7%	63.3%
Immunologicals	Me (IQR)
IL-1b (pg/mL)	1.69 (.86-3.01)
IL-6 (pg/mL)	1.05 (.57-2.50)
IL-8 (pg/mL)	6.00 (5.04-8.50)
IL-10 (pg/mL)	.63 (.23-1.62)
IL-12 (pg/mL)	.42 (.21-1.20)
TNFa (pg/mL)	1.34 (.53-2.72)
%CD3^**	67.90 (58.80-72.73)
%CD4^**	51.70 (41.35-59.00)
%CD8^**	31.70 (26.58-38.03)
%CD4HLADR+CD38+^**	3.11 (1.84-4.93)
%CD4HALDR-CD38-^**	46.35 (36.80-55.83)
%CD4CD69+^**	.32 (.12-0.83)
%CD4Ki67+^**	3.90 (2.32-5.77)
%CD8HLADR+CD38+^**	8.42 (5.23-12.70)
%CD8HALDR-CD38-^**	49.00 (32.90-62.53)
%CD8CD69+^**	1.01 (.60-1.56)
%CD8Ki67+^**	2.63 (1.61-4.40)

		r _s	p
Sexual Relationships	IL8	.41	.02
Sexual partners	Depression	.43	.02
	Memory	-.36	.49
	IL12	-.38	.03
	CD4 HLA DR- CD38+ (% cells)	-.36	.04
Unprotected sex	IL8	.36	,04
Dopamine	Anxiety	-.49	.007
	CD4 HLA DR+CD38+ (% cells)	-.39	.03
	CD8 Ki67+	-.38	.04
Adrenaline	Cortisol	.51	.009
	Openness to experience	-.42	.03
	CD4	.41	.03
Noradrenaline	IL6	-.39	.04
Serotonin	CD4 HLA DR+ CD38+ (% cells)	-.39	.03
	CD4 HLA DR- CD38- (% cells)	.37	.04
	CD8 CD38+	-.43	.01
	CD8 HLA DR- CD38- (% cells)	.42	.02
Cortisol	IL6	-.41	.02
Anxiety	Depression	.64	< .001
	Neuroticism	.70	< .001
	Agreeableness	-.45	.01
	Conscientiousness	-.40	.03
	CD4 CD69+	.42	.02
	CD4 HLA DR- CD38-	-.42	.02
	CD8 HLA DR+ CD38+	.42	.02
	CD8 HLA DR- CD38-	-.45	.01
Depression	Neuroticism	.76	< .001
	Agreeableness	-.48	.01
	Conscientiousness	-.49	.009
	IL8	-.38	.04
Stress	Conscientiousness	-.40	.03
Stress	Executive functioning	-.38	.04
Neuroticism	CD4 CD69+	.37	.04
Extraversion	CD4 HLA DR+ CD38+	-.40	.03
	CD8	.45	.01
	CD8 CD69+	-.42	.02
	CD8 HLA DR+	-.42	.02
Executive functioning	CD3	.44	.01
Memory	CD3	.50	.004

Instituto de Psicologia, Universidade de Brasília Instituto de Psicologia, Universidade de Brasília, 70910-900 - Brasília - DF - Brazil, Tel./Fax: (061) 274-6455 - Brasília - DF - Brazil
E-mail: revistaptp@gmail.com

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[1] * E-mail: jorge.restrepo67@tdea.edu.co