| Baba et al., 200699 Sreenivasa Baba C, Alexander G, Kalyani B, Pandey R, Rastogi S, Pandey A, et al. Effect of exercise and dietary modification on serum aminotransferase levels in patients with nonalcoholic steatohepatitis. J Gastroenterol Hepatol. 2006; 21(1 Pt 1):191-8.
|
|
Biopsy |
|
65 |
|
Moderate calorie restriction in obese individuals + PA (40' walk 3-4 times per week, 60 to 70% maximum HR) |
|
Beneficial effect limited to patients who fulfilled the dietary programs and PA (n=44) |
| Thamer et al., 20071010 Thamer C, Machann J, Stefan N, Haap M, Schäfer S, Brenner S, et al. High visceral fat mass and high liver fat are associated with resistance to lifestyle intervention. Obesity (Silver Spring). 2007; 15(2):531-8.
|
|
MRI |
|
112 |
|
Reduction of fat intake up to 30% of total calories, reduction of saturated fatty acids up to 10% of total calories, increased daily dose of fiber intake to 15 g/1,000 kcal, and increased PA to 3h/week for 9 months |
|
Reduction of IR and fat in the liver |
| Albu et al., 20101111 Albu JB, Heilbronn LK, Kelley DE, Smith SR, Azuma K, Berk ES, et al.; Look AHEAD Adipose Research Group. Metabolic changes following a 1-year diet and exercise intervention in patients with type 2 diabetes. Diabetes. 2010; 59(3):627-33.
|
|
MRI |
|
58 |
|
Decreased calorie intake (-500 kcal/day) and increased PA (≥ 175 min/week), during 12 months |
|
Reduction of fasting blood glucose and fat in the liver |
| Promrat et al., 20101212 Promrat K, Kleiner DE, Niemeier HM, Jackvony E, Kearns M, Wands JR, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010; 51(1):121-9.
|
|
Biopsy |
|
65 |
|
Caloric restriction (1,000-1,200 kcal/day if baseline weight < 200 lb or 1,200-1,500/day if initial weight > 200 lb) and a daily fat target of 25% and 200 minutes of moderately intense PA per week for 12 months |
|
Significant improvement in steatosis, lobular inflammation, hepatocyte ballooning and NAS in patients with a decrease of at least 7% of total body weight |
| Lazo et al., 20101313 Lazo M, Solga SF, Horska A, Bonekamp S, Diehl AM, Brancati FL, et al.; Fatty Liver Subgroup of the Look AHEAD Research Group. Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes. Diabetes Care. 2010; 33(10):2156-63.
|
|
MRI |
|
5,145 |
|
Moderate caloric restriction (1,200-1,500 kcal/day for individuals weighing < 114 kg and 1,500-1,800 kcal/day for those weighing > 114 kg) and increased physical activity with a target of 175 min of moderately intense PA per week for 12 months |
|
Reduction in liver fat |
| Oh et al., 201488 Oh S, Shida T, Yamagishi K, Tanaka K, So R, Tsujimoto T, et al. Moderate to vigorous physical activity volume is an important factor for managing nonalcoholic fatty liver disease: a retrospective study. Hepatology. 2015; 61(4):1205-15.
|
|
Fibroscan |
|
169 (obese) |
|
Calorie restriction of 1,680 kcal/day and PA for less than 250 min per week or 250 min or more per week |
|
Reduction of serum ferritin and adiponectin and reduction of liver fat |
| Vilar-Gomez et al., 20151414 Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, et al. Weight loss via lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015; 149(2):367-78.e5.
|
|
Biopsy |
|
293 |
|
Low-calorie diet (750 kcal/day less than the calculated daily energy need) and PA for 200 min a week for 52 weeks |
|
Histological improvement, including fibrosis, when weight loss was greater than or equal to 10% |
