⁶⁸Ga-PSMA PET/CT: effect of external cooling on salivary gland uptake

PET/CT com ⁶⁸Ga-PSMA: efeitos do resfriamento externo na captação pelas glândulas salivares

Abstract

Objective:

To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (⁶⁸Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy.

Materials and Methods:

Ten patients with prostate cancer were submitted to ⁶⁸Ga-PSMA positron emission tomography/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student’s t-tests were used in order to compare the results.

Results:

In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004).

Conclusion:

The use of ECSG does not appear to reduce ⁶⁸Ga-PSMA uptake by the salivary glands. In addition, there is yet no evidence that ECSG is effective in preventing salivary gland toxicity.

Keywords:
Salivary glands; Hypothermia, induced; Positron emission tomography computed tomography; ⁶⁸Ga-PSMA; ¹⁷⁷Lu-PSMA-617; Prostatic neoplasms, castration-resistant