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Oral delivery system for peptides and proteins: I. Approaches to improve oral bioavailability

There are hundreds of peptides and proteins clinically relevant. The difficulties associated with their oral administration have been responsible for the major efforts in developing ways to improve oral bioavailability. Both these subjects are described in this review. The potentiality of microencapsulation presents this technique as a privileged approach for the oral delivery of peptide and protein drugs.

Absorption enhancer; Formulation; Microencapsulation; Peptide drugs; Protease inhibitors


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