Tendência temporal das coberturas vacinais no primeiro ano de vida no Brasil

Neves, Ana Beatriz Batista; Silva, Lucas Emanuel de Oliveira; Amaral, Gabriela Morais Celestino; Silva, Maria Rosa da; Santos Júnior, Claudio José dos

Ana Beatriz Batista Neves ^*Corresponding author. E-mail: anabeatrizbnvs@gmail.com (A. B. B. Neves)

Study design

Data collection

Data analysis

Manuscript writing

Manuscript revision

Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.

https://orcid.org/0000-0001-7203-7409

Lucas Emanuel de Oliveira Silva

Data collection

Data analysis

Manuscript writing

Manuscript revision

Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.

https://orcid.org/0000-0002-5013-6278

Gabriela Morais Celestino Amaral

Data analysis

Manuscript writing

Manuscript revision

Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.

https://orcid.org/0000-0002-2056-161X

Maria Rosa da Silva

Study design

Manuscript revision

Study supervision

Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, AL, Brazil.

Universidade de São Paulo, São Paulo, SP, Brazil.

https://orcid.org/0000-0001-7431-9266

Claudio José dos Santos Júnior

Study design

Data collection

Manuscript revision

Study supervision

Universidade de São Paulo, São Paulo, SP, Brazil.

https://orcid.org/0000-0002-2853-1968

Corresponding author. E-mail: anabeatrizbnvs@gmail.com (A. B. B. Neves)

Conflict of interests

The authors declare there is no conflict of interests.

Unit	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
Unit	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
Brazil	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.58 (−5.89; −1.20)	−0.02	−4.22 (−8.31; 0.06)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.10 (−5.42; −2.76)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.76 (−3.80; −1.71)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.56 (−4.21; −0.87)
North	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.92 (−5.20; −2.64)	−0.00	−1.94 (−5.99; 2.29)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.58 (−5.38; −3.77)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.03 (−5.48; −2.55)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.90 (−6.28; −1.46)
Northeast	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.83 (−6.33; −1.27)	−0.01	−2.92 (−7.17; 1.52)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.27 (−6.38; −2.11)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.11 (−4.57; −1.63)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.76 (−4.66; −0.81)
Southeast	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.85 (−7.19; −0.40)	−0.03	−6.67 (−13.34; 0.51)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.02 (−5.76; −2.25)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.58 (−3.54; −1.61)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.14 (−3.14; −0.84)
South	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.44 (−3.75; −1.12)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.42 (−4.68; −2.14)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.65 (−4.43; −2.86)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.60 (−2.31; −0.88)	−0.01	−1.78 (−3.68; 0.15)
Midwest	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.24 (−5.24; −1.20)	−0.01	−3.23 (−6.80; 0.46)	−0.02^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.17 (−6.18; −4.15)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.80 (−4.25; −1.32)	−0.01^* * p-value<0.05; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.19 (−5.34; −0.98)

FU	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
FU	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
AC	−0.01^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.32 (−5.67; −0.92)	0.04	10.58 (−6.83; 31.24)	0.00	−0.74 (−2.29; 0.83)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.38 (−6.87; −1.83)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.83 (−5.97; −1.64)
AP	−0.01	−2.32 (−4.68; 0.10)	−0.01	−1.39 (−3.80; 1.08)	−0.05^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−10.30 (−15.18; −5.14)	−0.03^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−6.20 (−9.92; −2.32)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.36 (−7.27; −1.36)
AM	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.69 (−5.07; −2.28)	−0.01	−2.49 (−5.08; 0.18)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.62 (−5.88; −1.30)	−0.01^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.02 (−5.78; −0.18)	−0.01^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.64 (−5.04; −0.19)
PA	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.54 (−7.53; −3.50)	−0.02	−3.64 (−11.13; 4.49)	−0.03^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−6.27 (−8.62; −3.86)	−0.03^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.64 (−8.50; −2.69)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.59 (−9.12; −1.93)
RO	−0.17^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.84 (−7.03; −0.53)	−0.02^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.58 (−7.35; −3.78)	−0.01	−1.88 (−5.24; 1.59)	−0.01	−2.21 (−4.63; 0.28)	−0.01	−1.83 (−4.92; 1.36)
RR	0.00	0.11 (−2.97; 3.29)	0.03	6.51 (−4.54; 18.85)	−0.01	−2.60 (−7.36; 2.40)	−0.01	−2.32 (−4.97; 0.39)	−0.01	−2.75 (−6.45; 1.10)
TO	0.00	0.70 (−0.39; 1.81)	0.01	3.30 (−0.82; 7.60)	−0.01^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.97 (−3.75; −2.18)	−0.01^* * p-value<0.05; FU: Federative Units; AC: Acre; AP: Amapá; AM: Amazonas; PA: Pará; RO: Rondônia; RR: Roraima; TO: Tocantins; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.40 (−2.10; −0.69)	−0.01	−1.38 (−3.34; 0.61)

FU	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
FU	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
AL	−0.02	−3.56 (−8.68; 1.84)	−0.02	−4.30 (−11.50; 3.48)	−0.01	−2.01 (−4.25; 0.28)	−0.01	−1.64 (−3.57; 0.34)	0.00	−0.41 (−3.30; 2.56)
BA	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.71 (−4.92; −2.48)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.29 (−3.86; −0.69)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.42 (−6.31; −2.48)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.84 (−5.38; −2.26)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.29 (−5.79; −0.73)
CE	−0.02	−4.72 (−10.10; 0.97)	−0.02	−5.39 (−13.92; 4.00)	−0.01	−2.72 (−6.59; 1.30)	0.00	−1.00 (−3.30; 1.35)	−0.01	−1.55 (−4.57; 1.56)
MA	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.50 (−8.83; −2.04)	−0.02	−5.12 (−12.21; 2.55)	−0.04^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−7.79 (−10.87; −4.61)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.24 (−7.30; −3.14)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.13 (−7.98; −2.18)
PB	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.73 (−7.89; −0.70)	−0.02	−3.70 (−11.11; 4.32)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.14 (−4.73; −1.52)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.59 (−4.40; −0.75)	−0.01	−1.73 (−4.15; 0.76)
PE	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.01 (−5.22; −0.75)	0.00	0.17 (−4.47; 5.05)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.73 (−7.63; −1.73)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.50 (−5.27; −1.70)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.32 (−3.68; −0.94)
PI	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.26 (−4.16; −0.32)	−0.01	−1.23 (−6.60; 4.45)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.13 (−6.91; −1.28)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.94 (−5.18; −0.66)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.45 (−4.59; −0.26)
RN	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.23 (−6.84; −1.55)	0.00	−1.02 (−8.89; 7.53)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.85 (−6.45; −1.18)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.28 (−5.97; −0.51)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.95 (−5.30; −0.54)
SE	−0.01	−2.18 (−5.54; 1.31)	−0.03^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−6.77 (−10.99; −2.35)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.70 (−5.56; −1.81)	−0.02^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.49 (−4.96; −1.98)	−0.01^* * p-value<0.05; FU: Federative Units; AL: Alagoas; BA: Bahia; CE: Ceará; MA: Maranhão; PB: Paraíba; PE: Pernambuco; PI: Piauí; RN: Rio Grande do Norte; SE: Sergipe; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.33 (−3.81; −0.84)

FU	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
FU	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
ES	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.52 (−4.06; −0.95)	−0.01	−2.80 (−6.24; 0.76)	−0.02^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.87 (−6.30; −3.42)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.02 (−3.96; −2.06)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.23 (−3.40; −1.04)
MG	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.15 (−3.36; −0.92)	−0.01	−1.70 (−5.06; 1.78)	−0.02^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.48 (−4.54; −2.41)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.83 (−2.74; −0.91)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.46 (−2.74; −0.16)
RJ	−0.03	−6.19 (−12.16; 0.18)	−0.05	−11.06 (−21.89; 1.26)	−0.03^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−7.37 (−14.15; −0.04)	−0.03^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−6.50 (−10.54; −2.28)	−0.02	−3.77 (−7.53; 0.15)
SP	−0.02^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.00 (−7.57; −0.30)	−0.03	−7.58 (−15.38; 0.93)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.31 (−4.45; −2.15)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.96 (−2.88; −1.04)	−0.01^* * p-value<0.05; FU: Federative Units; ES: Espírito Santo; MG: Minas Gerais; RJ: Rio de Janeiro; SP: São Paulo; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.93 (−3.13; −0.70)

FU	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
FU	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
PR	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.16 (−3.21; −1.09)	−0.02^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.96 (−6.60; −3.31)	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.33 (−3.99; −2.67)	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.91 (−2.72; −1.09)	−0.01	−2.05 (−4.19; 0.13)
RS	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.33 (−3.79; −0.85)	−0.01	−1.28 (−2.97; 0.45)	−0.02^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.97 (−4.27; −3.67)	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.51 (−2.58; −0.43)	−0.01	−1.51 (−3.47; 0.49)
SC	−0.01^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.17 (−5.09; −1.22)	−0.04^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−9.54 (−13.47; −5.44)	−0.02^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.68 (−5.72; −1.60)	0.00^* * p-value<0.05; FU: Federative Units; PR: Paraná; RS: Rio Grande do Sul; SC: Santa Catarina; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−1.14 (−1.58; −0.70)	−0.01	−1.71 (−3.40; 0.02)

FU	BCG		Hepatitis B		Pentavalent		Polio		Triple viral
FU	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)	β	APC (95%CI)
DF	−0.01	−2.46 (−5.47; 0.64)	−0.01^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.33 (−6.49; −0.06)	−0.01	−2.67 (−8.30; 3.30)	−0.01	−1.55 (−4.64; 1.64)	−0.01	−1.78 (−4.21; 0.72)
GO	−0.02^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.59 (−5.95; −3.21)	−0.01	−1.40 (−4.69; 2.01)	−0.03^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.84 (−6.62; −5.05)	−0.02^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−3.69 (−4.91; −2.46)	−0.02^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.72 (−7.22; −2.15)
MS	−0.01	−3.20 (−9.65; 3.70)	−0.02	−5.04 (−14.29; 5.12)	−0.03^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−5.74 (−7.94; 3.49)	−0.01	−2.20 (−6.35; 2.13)	−0.01	−1.98 (−6.23; 2.46)
MT	−0.01^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.33 (−4.04; −0.59)	−0.02^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.26 (−7.39; 1.03)	−0.02^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−4.59 (−6.54; −2.61)	−0.01^* * p-value<0.05; FU: Federative Units; DF: Distrito Federal, GO: Goiás; MS: Mato Grosso do Sul; MT: Mato Grosso; BCG: Bacille Calmette-Guerin; β: regression coefficient; APC: annual percent change (%); 95%CI: 95% confidence interval.	−2.70 (−3.96; −1.42)	−0.01	−2.48 (−4.90; 0.01)

[1] Corresponding author. E-mail: anabeatrizbnvs@gmail.com (A. B. B. Neves)

Brasil

Brasil

Tendência temporal das coberturas vacinais no primeiro ano de vida no Brasil

RESUMO

Objetivo:

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