In an endemic area where transmission of schistosomiasis has been interrupted 164 infected patients were treated with oxamniquine and praziquantel in reduced doses. Each individual took, under supervision, one 250 mg capsule of oxamniquine and one tablet of 300 mg of praziquantel. The doses of oxamniquine varied from 3.5 to 16.6 mg/kilo body weight and that of praziquantel from 4.2 to 20 mg. The control of cure was eight faecal examination for eggs by the Kato-Katz method carried out overaperiod ofsix months. The indices ofcure varied from 30 to 57%. The total percentage of cure ivas 40%. Tolerance was good. Our results show a low cure rate and an apparent lack of synergism of the association of oxamniquine and praziquantel in reduced doses in the treatment of Schistosoma mansoni in Brazil.
Schistosomiasis; Treatment; Association of oxamniquine and praziquantel