Evaluation of the efficacy of azithromycin and pyrimethamine, alone or in combination, for the treatment of experimental infection of mice with Toxoplasma gondii

Abstract

The efficacy of azithromycin and pyrimethamine in experimental infection of mice with Toxoplasma gondii was tested. Daily dosages of 200mg/kg and 12.5mg/kg, respectively, were given orally over a period of ten days. The medications were administered in combination or separately. The combined use of the drugs yielded better results, and a similar investigation using a cystogenic strain of the parasite will be conducted in a future study.

Infection by Toxoplasma gondii; Mice; Treatment; Azythromicin; Pyrimethamine