Increased antimicrobial resistance in <i>Klebsiella pneumoniae</i> from a University Hospital in Rio Grande do Sul, Brazil

Lorenzoni, Vinícius Victor; Rubert, Franciéli da Costa; Rampelotto, Roberta Filipini; Hörner, Rosmari

doi:10.1590/0037-8682-0362-2017

Acessibilidade / Reportar erro

Brasil

Revista da Sociedade Brasileira de Medicina Tropical

Español English

Brasil

Español English

sumário « anterior atual seguinte »

Sumário

Short Communication • Rev. Soc. Bras. Med. Trop. 51 (05) • Sep-Oct 2018 • https://doi.org/10.1590/0037-8682-0362-2017 copy

Increased antimicrobial resistance in Klebsiella pneumoniae from a University Hospital in Rio Grande do Sul, Brazil

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

INTRODUCTION

The spread of multidrug-resistant Gram-negative bacilli is a health threat, limiting therapeutic options and increasing morbimortality rates.

METHODS:

This study aimed to evaluate the antimicrobial susceptibility profile of 1805 Klebsiella pneumoniae isolates collected from Hospital Universitário de Santa Maria between January 2015 and December 2016.

RESULTS:

Resistance to colistin (239.3%), meropenem (74.2%), ciprofloxacin (68%), gentamicin (35.1%), tigecycline (33.9%), imipenem (29.7%), ertapenem (26.8%), and amikacin (21.4%) was found increased.

CONCLUSIONS:

Infection control measures in the hospitals are necessary for reducing the spread of multidrug-resistant microorganisms and preventing efficacy loss of these drugs.

Keywords:
Colistin; Klebsiella pneumoniae; Multi-drug resistance

Antimicrobial agent	MIC Range	2015 (n = 784)			2016 (n = 1021)
	(µg/mL)	MIC₅₀/MIC₉₀	R	S	MIC₅₀/MIC₉₀	R	S
			(n;%)	(n;%)		(n;%)	(n;%)
AMI	0.5-64	2/16	22;	762;	2/16	35;	986;
			2.8	97.2		3.4	96.6
CIP	0.25-16	4/4	321; 40.9	463;	4/4	701;	320;
				59.1		68.7	31.3
COL	0.5-16	0.5/0.5	48;	736;	0.5/16	211;	810;
			6.1	93.9		20.7	79.3
ERT	0.5-8	0.5/8	328;	456;	4/8	541;	480;
			41.8	58.2		53	47
GEN	1-16	1/16	326;	458;	16/16	574;	447;
			41.6	58.4		56.2	43.8
IMI	0.25-16	0.25/16	245;	539;	0.25/16	414;	607;
			31.3	68.7		40.6	59.4
MER	0.25-16	0.25/16	237;	547;	2/16	537;	484;
			30.2	69.8		52.6	47.4
TIG	0.25-8	0.5/8	250;	534;	1/8	436;	585;
			31.9	68.1		42.7	57.3

Antimicrobial agent	MIC Range	2015 (n = 48)			2016 (n = 211)
	(µg/mL)	MIC₅₀/	R	S	MIC₅₀/	R	S
		MIC₉₀	(n;%)	(n;%)	MIC₉₀	(n;%)	(n;%)
AMI	0.5-64	8/16	6;	42;	4/16	13;	198;
			12.5	87.5		10.9	89.1
CIP	0.25-16	4/4	46;	2;	4/4	208;	3;
			95.8	4.2		98.6	1.4
ERT	0.5-8	8/8	40;	8;	8/8	201;	10;
			83.3	16.7		95.3	4.7
GEN	1-16	16/16	32;	16;	16/16	195;	16;
			66.7	33.3		92.4	7.6
IMI	0.25-16	16/16	40;	8;	8/16	203;	8;
			83.3	16.7		96.2	3.8
MER	0.25-16	16/16	40;	8;	16/16	203;	8;
			83.3	16.7		96.2	3.8
TIG	0.25-8	8/8	42;	6;	2/8	187;	24;
			87.5	12.5		88.6	11.4

Sociedade Brasileira de Medicina Tropical - SBMT Caixa Postal 118, 38001-970 Uberaba MG Brazil, Tel.: +55 34 3318-5255 / +55 34 3318-5636/ +55 34 3318-5287, http://rsbmt.org.br/ - Uberaba - MG - Brazil
E-mail: rsbmt@uftm.edu.br

Acompanhe os números deste periódico no seu leitor de RSS

[1] Corresponding author: Drª Rosmari Hörner. e-mail:rosmari.ufsm@gmail.com.