Aydemir et al.21
|
2011 |
Turkey |
31 preterm infants with fungal septicemia |
30 preterm infants who had no invasive fungal infection |
No association between codon 54 (B allele) polymorphism in exon 1 of the MBL gene and massive fungal sepsis |
Hartel et al.9
|
2011 |
Germany |
Cohort 1: 344 septic VLBW infants;
Cohort 2: 555 septic VLBW infants |
Cohort 1: 1600 non-septic VLBW infants;
Cohort 2: 371 non-septic VLBW infants |
No association between late onset sepsis and the SNP TNF- 308 G/A |
Abu-Maziad et al.22
|
2010 |
USA |
79 preterm infants with sepsis |
202 preterm infants without sepsis |
TLR2, TLR5, IL-10 and PLA2G2A polymorphisms predispose to sepsis in preterm infants |
Auriti et al.23
|
2010 |
Italy |
42 neonates with sepsis |
85 neonates without infection |
No association between the MBL2 genotypes and sepsis |
Koroglu et al.24
|
2010 |
Turkey |
Proven sepsis: 11 preterm newborns;
Clinical sepsis: 42 preterm newborns |
57 preterm infants with no sepsis |
No association between MBL polymorphism and culture-proven sepsis; however, a risk of clinical sepsis was shown |
Spiegler et al.25
|
2010 |
Germany |
706 septic VLBW infants genotyped for ACE-ins/del genotype;
709 septic VLBW infants genotyped for ATR-1166A/C genotype |
503 non-septic VLBW infants
genotyped for ACE-ins/del genotype;495 non-septic VLBW infants genotyped for ATR-1166A/C genotype |
No impact of any renin-angiotensin system SNPs; no association was found between the ATR-1166A/C genotype or ACE-ins/del genotype and neonatal sepsis |
Abdel-Hady et al.26
|
2009 |
Egypt |
54 septic full-term neonates |
70 non-septic matched full-term neonates |
The IL-6 -174 and IL-10-1082 genotypes were not significantly different in neonates with bloodstream infections, compared with controls |
Bertalan et al.27
|
2008 |
Hungary |
22 septic preterm neonates |
103 non-septic preterm neonates |
BclI, N363S and ER22/23EK polymorphisms of the glucocorticoid receptor gene were not associated with risk of sepsis |
Reiman et al.28
|
2008 |
Finland |
11 septic preterm VLBW infants |
96 non-septic preterm VLBW infants |
Association between the IL-6-174 CC genotype and increased sepsis prevalence in VLBW infants |
Dzwonek et al.29
|
2008 |
England/
Poland |
47 septic preterm infants |
111 non-septic preterm infants |
Analyses of the effect of MBL genotype in newborns of gestational age < 28 weeks and birth weight < 1000 g did not show a statistically significant association with sepsis |
van der Zwet et al.30
|
2008 |
Holland |
Low MBL genotype: 8 septic neonates;
Medium MBL genotype: 15 septic neonates;
High MBL genotype: 41 septic neonates |
Low MBL genotype: 30 non-septic neonates;
Medium MBL genotype: 60 non-septic neonates
High MBL genotype: 44 non-septic neonates |
No relationship was found between MBL genotype and the risk of nosocomial sepsis |
Schueller et al.31
|
2006 |
Germany |
67 preterm infants (< 32 weeks of gestation) and early-onset sepsis |
102 healthy newborns born after 32 weeks of gestation |
No association between polymorphisms of TNF-308 and LTA +252 and early-onset sepsis in newborns with < 32 weeks of gestation. |
Derzbach et al.32
|
2006 |
Hungary |
36 septic LBW infants |
89 non-septic LBW infants |
No association was found between the polymorphisms E-selectin Ser128Arg, P-selectin Thr715Pro, L-selectin Pro213Ser and the risk of sepsis |
Hartel et al.33
|
2006 |
Germany |
198 septic VLBW infants |
1008 non-septic VLBW infants |
Higher rate of sepsis for carriers of factor XIII Val34Leu SNP |
Baier et al.34 |
2006 |
Canada |
148 septic VLBW infants |
145 non-septic VLBW infants |
The IL-6 -174C allele was associated with increased incidence of late bloodstream infection (BSI) in AA but not in Caucasian infants. The IL-10 -1082A allele was associated with increased incidence of late BSI. The CD14 -260 C/T SNP did not alter the overall risk of BSI in ventilated
VLBW infants. |
Göpel et al.35
|
2006 |
Germany |
97 VLBW infants who evolved with sepsis |
320 non-septic VLBW infants |
No association between sepsis and
IL-6-174 genetic polymorphism |
John Baier et al.36
|
2005 |
Canada |
149 septic VLBW infants |
146 non-septic VLBW infants |
The ACE I/D polymorphism did not have a significant effect on
incidence of sepsis |
Hedberg et al.37
|
2004 |
USA |
82 mechanically ventilated VLBW infants with late bacteremia |
91 mechanically ventilated VLBW infants without late bacteremia |
The TNF-308 G/A SNP had no influence on the incidence of either early or late bacteremia or fungemia |
Ahrens et al.38
|
2004 |
Germany |
50 septic VLBW infants |
306 non-septic VLBW infants |
VLBW infants carrying the
NOD2-3020ins C allele (n = 15) and the IL-6-174 G allele (n = 121) had a significantly higher rate of blood culture-proven sepsis. |
Bessler et al.39
|
2004 |
Israel |
34 septic preterm LBW infants aged 24-35 weeks of gestation |
61 non-septic preterm LBW infants aged 24-35 weeks of gestation |
No impact of IL-1ra genetic polymorphism on early onset sepsis |
Harding et al.40
|
2003 |
England |
51 septic preterm infants aged < 32 weeks of gestation. |
106 non-septic preterm infants aged < 32 weeks of gestation. |
Increased confirmed bacteriological sepsis with IL-6-174 GG allele |
Treszl et al.41
|
2003 |
Hungary |
33 septic VLBW neonates |
35 non-septic VLBW neonates |
TNF-308, IL-1β, IL-4 receptor α chain, IL-6 and IL-10 genes are not risk factors for sepsis in LBW infants |