A hypothetical immunemediated unifying mechanism for the Holmes-Adie syndrome

Costa, C. M. de Castro; Hees, J. Van; Vale, D. C. do

doi:10.1590/S0004-282X1988000200013

Abstracts

The Holmes-Adie syndrome consists of pupillotonia, arreflexia and autonomic dysfunction. Some explanations for these different symptoms have been attempted, centred upen neuropathological and electrophysiological findings. A hypothetical immunemediated mechanism, as in the Guillain Barré syndrome, is presented in this paper for explaining the three chief symptoms of the syndrome.

A síndrome de Holmes-Adie consiste de pupila tônica, arreflexia patelar e disfunção autonômica. As explicações desses diferentes sintomas têm-se baseado em achados neuropatológicos e eletrofisiológicos. Neste trabalho apresenta-se uma hipótese imunológica para a fisiopatogenia da síndrome, de modo semelhante ã da síndrome de Guillain-Barré.

C. M. de Castro Costa^I; J. Van Hees^II; D. C. do Vale^III

^IDepartamento de Fisiologia e Farmacologia, Universidade Federal do Ceará (UFC)

^IIGasthuisberg-Afdeling Neurologie, Leuven (Belgium)

^IIIHospital das Clínicas, UFC

SUMMARY

The Holmes-Adie syndrome consists of pupillotonia, arreflexia and autonomic dysfunction. Some explanations for these different symptoms have been attempted, centred upen neuropathological and electrophysiological findings. A hypothetical immunemediated mechanism, as in the Guillain Barré syndrome, is presented in this paper for explaining the three chief symptoms of the syndrome.

RESUMO

A síndrome de Holmes-Adie consiste de pupila tônica, arreflexia patelar e disfunção autonômica. As explicações desses diferentes sintomas têm-se baseado em achados neuropatológicos e eletrofisiológicos. Neste trabalho apresenta-se uma hipótese imunológica para a fisiopatogenia da síndrome, de modo semelhante ã da síndrome de Guillain-Barré.

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Departamento de Fsiologia e Farmacologia, Universidade Federal do Ceará - Caixa Postal 657 - 60000 Fortaleza CE - Brasil.

1. Adie WJ - Tonic pupils and absent tendon reflexes. Brain 55: 98, 1932.
2. Hardin WB, Gay AJ - The phenomenon of benign arreflexia: review of the Holmes-Adie syndrome and a study of the Achilles reflex. Neurology 15: 613, 1965.
3. Harriman DGF, Garland H - The pathology of Adie's syndrome. Brain 91: 401, 1968.
4. Lowenfeld IE, Thompson HS - The tonic pupil: a reevaluation. Am J Ophthalm 63: 46, 1967.
5. Martinelli P, Montagna P, Gabellini AS - Holmes-Adie-syndrome (Letter). J Neurol Neurosur Psychiat 43: 1147, 1980.
6. Massey EW - Pupillary disautonomia and migraine: is Adie's pupil caused by migraine? Headache 21: 143, 1981.
7. McComas AJ, Payan J - Motoneurone excitability in the Holmes-Adie syndrome. In Andrew BL (ed): Control and Innervation of Skeletal Muscle. Livingstone, Edinburg, 1966.
8. Pasco M - Das Adie-syndrome: Betrachtungen uber zwei Falle. Klin Mbl Augenheilk 176: 835, 1980.
9. Spector RH, Bachman DL - Bilateral Adie's tonic pupil with anhidrosis and hyperthermia. Arch Neurol 41: 342, 1984.
10. Trautmann JC - Disease of the third, fourth and sixth cranial nerves. In Dyck PJ, Thomas PK, Lambert EH (eds): Peripheral Neuropathy. Saunders, Philadelphia, 1975, vol 1, pg 515, 1975,
11. Ulrich J - Morphological basis of Adie's syndrome, Eur Neurol 19: 390, 1980.
12. Warwick R, Williams PL - Neurologia. In Gray Anatomia. Ed 35. Guanabara Koogan, Rio, 1979, pg 911, 1001.
13. Wirtschafter JD, Herman WK - Low concentration eserine therapy for the tonic pupil (Adie) Syndrome. Ophtalmology 87: 1037, 1980.
14. Wirtschafter JD, Volk CR, Sawchuk RJ - Transaqueous diffusion of acetylcholine to denervated iris sphincter muscle: a mechanism for the tonic pupil syndrome (Adie syndrome). Ann Neurol 4: 1, 1978.

A hypothetical immunemediated unifying mechanism for the Holmes-Adie syndrome

Uma imune-hipótese unificante para o mecanismo da síndrome de Holmes-Adie

Publication Dates

Publication in this collection
21 June 2011
Date of issue
June 1988

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Adie WJ - Tonic pupils and absent tendon reflexes. Brain 55: 98, 1932.

[2] 2. Hardin WB, Gay AJ - The phenomenon of benign arreflexia: review of the Holmes-Adie syndrome and a study of the Achilles reflex. Neurology 15: 613, 1965.

[3] 3. Harriman DGF, Garland H - The pathology of Adie's syndrome. Brain 91: 401, 1968.

[4] 4. Lowenfeld IE, Thompson HS - The tonic pupil: a reevaluation. Am J Ophthalm 63: 46, 1967.

[5] 5. Martinelli P, Montagna P, Gabellini AS - Holmes-Adie-syndrome (Letter). J Neurol Neurosur Psychiat 43: 1147, 1980.

[6] 6. Massey EW - Pupillary disautonomia and migraine: is Adie's pupil caused by migraine? Headache 21: 143, 1981.

[7] 7. McComas AJ, Payan J - Motoneurone excitability in the Holmes-Adie syndrome. In Andrew BL (ed): Control and Innervation of Skeletal Muscle. Livingstone, Edinburg, 1966.

[8] 8. Pasco M - Das Adie-syndrome: Betrachtungen uber zwei Falle. Klin Mbl Augenheilk 176: 835, 1980.

[9] 9. Spector RH, Bachman DL - Bilateral Adie's tonic pupil with anhidrosis and hyperthermia. Arch Neurol 41: 342, 1984.

[10] 10. Trautmann JC - Disease of the third, fourth and sixth cranial nerves. In Dyck PJ, Thomas PK, Lambert EH (eds): Peripheral Neuropathy. Saunders, Philadelphia, 1975, vol 1, pg 515, 1975,

[11] 11. Ulrich J - Morphological basis of Adie's syndrome, Eur Neurol 19: 390, 1980.

[12] 12. Warwick R, Williams PL - Neurologia. In Gray Anatomia. Ed 35. Guanabara Koogan, Rio, 1979, pg 911, 1001.

[13] 13. Wirtschafter JD, Herman WK - Low concentration eserine therapy for the tonic pupil (Adie) Syndrome. Ophtalmology 87: 1037, 1980.

[14] 14. Wirtschafter JD, Volk CR, Sawchuk RJ - Transaqueous diffusion of acetylcholine to denervated iris sphincter muscle: a mechanism for the tonic pupil syndrome (Adie syndrome). Ann Neurol 4: 1, 1978.