Intracerebral Granulocytic Sarcoma in recurrence of Chronic Myeloid LeukemiaA 21-year-old male with a 2-year diagnosis of chronic myeloid leukemia in complete hematologic and cytogenetic responses was admitted to hospital with drowsiness, headache and seizures. Laboratory evaluation disclosed leucocitosis with 19.0% of peripheral blasts. Brain magnetic resonance imaging (MRI) (Figure 1) corroborated the diagnosis of granulocytic sarcoma (GS) in blast crisis. MRI performed 38 days after chemotherapy was indicative of tumor regression (Figure 2).
Figure 1
(A) Magnetic resonance imaging (MRI) shows an intra-axial right parietal solid lesion, isointense on T2 weighted image; (B) With edema and mass effect seen on FLAIR; (C) MRI T1 weighted image post contrast shows a heterogeneous enhancement hyperintense in (D) diffusion weighted imaging and (E) hypointense in ADC map, characterizing restricted diffusion.
(A) Magnetic resonance imaging (MRI) shows an intra-axial right parietal solid lesion, isointense on T2 weighted image; (B) With edema and mass effect seen on FLAIR; (C) MRI T1 weighted image post contrast shows a heterogeneous enhancement hyperintense in (D) diffusion weighted imaging and (E) hypointense in ADC map, characterizing restricted diffusion.
Figure 2
Follow up magnetic resonance imaging after 38 days of chemotherapy with methotrexate and cytosine arabinoside shows significant reduction of the tumor and mass effect on (A) T2 weighted image and (B) FLAIR; (C) ADC map shows areas of high signal suggesting the cellularity of the tumor was reduced over this period.
Follow up magnetic resonance imaging after 38 days of chemotherapy with methotrexate and cytosine arabinoside shows significant reduction of the tumor and mass effect on (A) T2 weighted image and (B) FLAIR; (C) ADC map shows areas of high signal suggesting the cellularity of the tumor was reduced over this period.
GS is an extramedullary solid tumor composed of immature myeloid cells1. It develops before, during or after the onset of myeloid leukemia2. Intra-axial GS without involvement of skull or meninges is rare3.
References
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1 Audouin J, Comperat E, Le Tourneau A, Camilleri-Broët S, Adida C, Molina T et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis. Int J Surg Pathol 2003;11(4):271-82. http://dx.doi.org/10.1177/106689690301100404
» https://doi.org/10.1177/106689690301100404 -
2 Suzer T, Colakoglu N, Cirak B, Keskin A, Coskun E, Tahta K. Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature. J Clin Neurosci. 2004;11(8):914-7. http://dx.doi.org/10.1016/j.jocn.2003.12.018
» https://doi.org/10.1016/j.jocn.2003.12.018 -
3 Lee SH, Park J, Hwang SK. Isolated recurrence of intracerebral granulocytic sarcoma in acute lymphoblastic leukemia: a case report. J Neurooncol. 2006;80(1):101-4. http://dx.doi.org/10.1007/s11060-006-9163-8
» https://doi.org/10.1007/s11060-006-9163-8
Publication Dates
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Publication in this collection
Jan 2015
History
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Received
12 Aug 2014 -
Reviewed
06 Sept 2014 -
Accepted
26 Sept 2014
