The frequency of blood-born viral infections in a population of multitransfused Brazilian patients

Covas, Dimas T.; Boturão Neto, Edmir; Zago, Marco A.

doi:10.1590/S0036-46651993000300008

Abstracts

The frequency of viral markers for hepatitis B (HBV) and C (HCV), human immunodeficiency virus-1 (HIV-1) and human T-lymphotropic virus-1 (HTLV-1) was evaluated in 32 Brazilian ß-thalassemia multitransfused patients. Additionaly the serum concentrations of ferritin and alanine aspartate transaminase (ALAT) were determined. The results show a high prevalence of markers of infection by HBV (25.0%) and HCV (46.8%) and a low prevalence of markers for HIV-1 and HTLV-1. No correlations were demonstrated between the presence of the hepatitis markers and the number of units transfused or the serum concentrations of ferritin and ALAT.

Blood-Born Viral Infections; ß-thalassemia; Hepatitis; HIV-1; HTLV-1

A freqüência de marcadores virais para hepatite B (HBV), C (HCV), vírus da imunodeficiência humana-1 (HIV-1) e vírus linfotrópico-T humano (HTLV-1) foi avaliada em 32 pacientes brasileiros multitransfundidos, portadores de ß-talassemia. Adicionalmente determinou-se a concentração sérica de transaminase alani-na aspártica (ALAT) e de ferritina. Os resultados mostraram alta prevalência de marcadores para HBV (25,0%) e HCV (46,8%) e baixa prevalência de marcadores para HIV-1 e HTLV-1. Não se demonstrou correlação entre a presença de marcadores para hepatite e o número de unidades transfundidas ou com as concentrações séricas de ferritina e ALAT.

EPIDEMIOLOGY

The frequency of blood-born viral infections in a population of multitransfused Brazilian patients

Freqüência de infecções virais transmitidas por transfusões em uma população de pacientes brasileiros multitransfundidos

Dimas T. Covas; Edmir Boturão Neto; Marco A. Zago

Regional Blood Center and Division of Hematology, School of Medicine of Ribeirão Preto

^{Address for correspondence} Address for correspondence: Dr. Dimas Tadeu Covas Hemocentro de Ribeirão Preto 14048-900 Ribeirão Preto, Brazil FAX nº 55 16 633-11.44

SUMMARY

The frequency of viral markers for hepatitis B (HBV) and C (HCV), human immunodeficiency virus-1 (HIV-1) and human T-lymphotropic virus-1 (HTLV-1) was evaluated in 32 Brazilian ß-thalassemia multitransfused patients. Additionaly the serum concentrations of ferritin and alanine aspartate transaminase (ALAT) were determined. The results show a high prevalence of markers of infection by HBV (25.0%) and HCV (46.8%) and a low prevalence of markers for HIV-1 and HTLV-1. No correlations were demonstrated between the presence of the hepatitis markers and the number of units transfused or the serum concentrations of ferritin and ALAT.

Key words: Blood-Born Viral Infections; ß-thalassemia; Hepatitis; HIV-1; HTLV-1.

RESUMO

A freqüência de marcadores virais para hepatite B (HBV), C (HCV), vírus da imunodeficiência humana-1 (HIV-1) e vírus linfotrópico-T humano (HTLV-1) foi avaliada em 32 pacientes brasileiros multitransfundidos, portadores de ß-talassemia. Adicionalmente determinou-se a concentração sérica de transaminase alani-na aspártica (ALAT) e de ferritina. Os resultados mostraram alta prevalência de marcadores para HBV (25,0%) e HCV (46,8%) e baixa prevalência de marcadores para HIV-1 e HTLV-1. Não se demonstrou correlação entre a presença de marcadores para hepatite e o número de unidades transfundidas ou com as concentrações séricas de ferritina e ALAT.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

2. BAHAKIM, H.; BAKIR, T.M.F.; ARIF, M. & RAMIA, S. - Hepatitis C virus antibodies in high-risk Saudi groups. Vox Sang. (Basel), 60: 162-164, 1991.

Recebido para publicação em 01/09/1992

Aceito para publicação em 03/12/1992

Supported by grants from the Fundação Hemocentro de Ribeirão Preto (FUNDHERP), Brazil.

References

1. ALDOURI, M.A.; WONKE, B.; HOFFBRAND, A.V.; FLYNN, D.M.; LAULICHT, M.; FENTON, L.A.; SHCEVER, P.J.; KIBBLER, C.C.; ALLWOOD, C.A.; BROWN, D. & THOMAS, H.C. - Iron state and hepatic disease in patients with thalassemia major, treated with long term subcutaneous desferrioxamine. J. clin. Path., 40: 1353-1359, 1987.
3. CONTRERAS, M.; BARBARA, J.A.; ANDERSON, C.C.; RANASINGHE, E.; MOORE, C; BRENNAN, M.T.; HOWELL, D.R.; ALOYSIUS, S. & YARDUMINA, A. - Low incidence of non-A, non-B post transfusion hepatitis in London confirmed by hepatitis C virus serology. Lancet, 337: 753-757, 1991.
4. EBELING, F. - Alanine aminotransferase, gamma-glutamyltransferase, antibodies to hepatitis C virus in blood donor screening. Vox Sang. (Basel), 60: 219-224, 1991.
5. EL-HAZMI, M.A.F. & RAMIA, S. - Frequencies of hepatitis B, delta and human immune deficiency virus markers in multitransfused Saudi patients with thalassemia and Sickle-cell disease. J. trop. Med. Hyg-, 92: 1-5, 1989.
6. JANOT, C.; CORROUCE, A.M. & MANIEZ, M. - Antibodies to hepatits C virus in French blood donors. Lancet, 11: 796-797, 1989.
7. MONTALEMBERT, M. & GIROT, R. - Infections in thalassemic patients (hepatitis and bone marrow transplantation related infections excluded). Prog. clin, biol. Res., 309: 231-238, 1989.
8. POLITIS, C. - Complications of blood transfusion in thalassemia. Prog. clin. biol. Res., 309: 67-76, 1989.
9. RESTI, M.; AZZARI, C; ROSSI, M.E.; VULLO, C.; BORGATTI, L. & VIERUCCI, A. - Prevalence of hepatitis C virus antibody in beta-thalassemic polytransfused children in a long-term follow-up. Vox Sang. (Basel), 60: 246-247, 1991.
10. SIRCHIA, G.; BELLOBUONO, A.; GIOVANETTI, A. & MARCONI, M. - Antibodies to hepatitis C virus in Italian blood donors. Lancet, 11: 797, 1989.
11. STEVENS, C.E.; TAYLOR, P.E.; PINDYCK, J.; CHOO, Q.L.; BRADLEY, D.W.; KUO, G. & HOUGHTON, M. - Epidemiology of hepatitis C virus. J. Amer. med. Ass., 263: 49-53, 1990.
12. TRIADOU, P.; REGNAT-LUSINCHI, A. & GIROT, R. - Use of ferritin/alanine aspartate transaminase ratio as an iron overload marker independent of liver cell damage. Europ. J. Haematol., 43: 423-427, 1989.
13. WONKE, B.; HOFFBRAND, A.V.; BROWN, D. & DUSHEIKO, G. - Antibody to hepatitis C virus in multiply transfused patients with thalassemia major. J. clin. Path., 43: 638-640, 1990.

Address for correspondence:

Dr. Dimas Tadeu Covas

Hemocentro de Ribeirão Preto

14048-900 Ribeirão Preto, Brazil

FAX nº 55 16 633-11.44

Publication Dates

Publication in this collection
20 July 2006
Date of issue
June 1993

History

Received
01 Sept 1992
Accepted
03 Dec 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALDOURI, M.A.; WONKE, B.; HOFFBRAND, A.V.; FLYNN, D.M.; LAULICHT, M.; FENTON, L.A.; SHCEVER, P.J.; KIBBLER, C.C.; ALLWOOD, C.A.; BROWN, D. & THOMAS, H.C. - Iron state and hepatic disease in patients with thalassemia major, treated with long term subcutaneous desferrioxamine. J. clin. Path., 40: 1353-1359, 1987.

[2] 3. CONTRERAS, M.; BARBARA, J.A.; ANDERSON, C.C.; RANASINGHE, E.; MOORE, C; BRENNAN, M.T.; HOWELL, D.R.; ALOYSIUS, S. & YARDUMINA, A. - Low incidence of non-A, non-B post transfusion hepatitis in London confirmed by hepatitis C virus serology. Lancet, 337: 753-757, 1991.

[3] 4. EBELING, F. - Alanine aminotransferase, gamma-glutamyltransferase, antibodies to hepatitis C virus in blood donor screening. Vox Sang. (Basel), 60: 219-224, 1991.

[4] 5. EL-HAZMI, M.A.F. & RAMIA, S. - Frequencies of hepatitis B, delta and human immune deficiency virus markers in multitransfused Saudi patients with thalassemia and Sickle-cell disease. J. trop. Med. Hyg-, 92: 1-5, 1989.

[5] 6. JANOT, C.; CORROUCE, A.M. & MANIEZ, M. - Antibodies to hepatits C virus in French blood donors. Lancet, 11: 796-797, 1989.

[6] 7. MONTALEMBERT, M. & GIROT, R. - Infections in thalassemic patients (hepatitis and bone marrow transplantation related infections excluded). Prog. clin, biol. Res., 309: 231-238, 1989.

[7] 8. POLITIS, C. - Complications of blood transfusion in thalassemia. Prog. clin. biol. Res., 309: 67-76, 1989.

[8] 9. RESTI, M.; AZZARI, C; ROSSI, M.E.; VULLO, C.; BORGATTI, L. & VIERUCCI, A. - Prevalence of hepatitis C virus antibody in beta-thalassemic polytransfused children in a long-term follow-up. Vox Sang. (Basel), 60: 246-247, 1991.

[9] 10. SIRCHIA, G.; BELLOBUONO, A.; GIOVANETTI, A. & MARCONI, M. - Antibodies to hepatitis C virus in Italian blood donors. Lancet, 11: 797, 1989.

[10] 11. STEVENS, C.E.; TAYLOR, P.E.; PINDYCK, J.; CHOO, Q.L.; BRADLEY, D.W.; KUO, G. & HOUGHTON, M. - Epidemiology of hepatitis C virus. J. Amer. med. Ass., 263: 49-53, 1990.

[11] 12. TRIADOU, P.; REGNAT-LUSINCHI, A. & GIROT, R. - Use of ferritin/alanine aspartate transaminase ratio as an iron overload marker independent of liver cell damage. Europ. J. Haematol., 43: 423-427, 1989.

[12] 13. WONKE, B.; HOFFBRAND, A.V.; BROWN, D. & DUSHEIKO, G. - Antibody to hepatitis C virus in multiply transfused patients with thalassemia major. J. clin. Path., 43: 638-640, 1990.