Testicular schistosomiasis as differential diagnosis for testicular nodules: a case report

Abstract

Despite its infrequent occurrence, testicular schistosomiasis forming pseudo-tumors can be considered in the differential diagnosis of testicular tumors, especially in areas where the parasitic disease is endemic. In this report, we present a case of testicular schistosomiasis caused by Schistosoma mansoni and mimicking a testicular neoplasm. We describe the patterns of a testicular nodule on ultrasonography and magnetic resonance images in a 46-year-old man. The nodule was removed after a pre-operative diagnosis of a non-malignant lesion. Histology demonstrated granulomas with epithelioid macrophages and eosinophils around S. mansoni eggs within a fibrous tissue that formed a nodular structure.

Keywords: Schistosomiasis; Testis; Testicular schistosomiasis; Tumor; Schistosoma mansoni; Radiology

INTRODUCTION

Testicular nodes have several potential origins, with neoplastic causes the most important diagnoses. However, when confronted with a testicular mass in a region of endemic schistosomiasis, this parasitic disease might be considered because it can cause a local granulomatous inflammation that presents as a mass similar to a testicular neoplasm.

In this article, we report a case of testicular schistosomiasis with emphasis on lesion patterns on ultrasonography (US) and magnetic resonance imaging (MRI).

CASE REPORT

A 46-year-old male patient, originally from Itororó, State of Bahia, attended the urology service at the University Hospital Cassiano Antônio Moraes from the Federal University of Espírito Santo, Brazil, with the initial complaint of difficulty urinating with progressive worsening, mainly during the previous year. He had no other complaints.

During the physical exam, the glans could not be exposed due to phimosis. The testicles were topical. A node of 1cm diameter was detected with hardened consistency in the right testicle, with no other changes.

The leukocyte count was 4,270 cells/mm ³ and indicated important eosinophilia (491 cells/mm ³ ; 11.5%); however, the parasitological feces examination was negative for protozoa and helminthes. The tumor markers human chorionic gonadotropin and alpha-fetoprotein were negative, and lactate dehydrogenase was slightly high (288, VR: 220).

Ultrasound (US) with Doppler examination of the scrotum showed a hypoechoic nodule image with regular contours and peripheral and central vascularity measuring 1.4 × 1.0 × 1.0cm in the lower third of the right testicle ( Figure 1 ).

Figure 1:
Ultrasonography of the right testis: A: hypoechoic nodule in the lower pole, with predominantly peripheral flow on color Doppler. B: The nodule measures 1.5 × 1.0 × 0.9cm with a partially defined and irregular contour. C: The nodule has a heterogeneous echo texture. D: The diameters of the right testicle C remain preserved.

On MRI of the testicles, a solid and hypervascularized nodule of indeterminate nature and bilateral ectasia of the veins of the pampiniform plexus were observed on the right testicle ( Figure 2 ).

Figure 2:
Magnetic resonance imaging: A: T2 sequence of a peripheral nodule in the right testis with hypointense, irregular outlines and well-defined limits, without promoting an expansive effect. B: T1 sequence of fat saturation without paramagnetic contrast in a peripheral nodule with mild hyperintensity. C: T1 sequence of fat saturation with paramagnetic contrast of a lateral peripheral nodule is observed in the right testicle showing intense enhancement; discrete peripheral enhancement in the tunica albuginea is also observed.

The patient was hospitalized and, due to a spare characteristic neoplasm on imaging, underwent a right partial orchiectomy with perioperative freezing; the result was negative for malignancy. We performed a circumcision and cystostomy after unsuccessfully passing a urethral catheter. There was almost nonexistent exposure of the glans, with plenty of grip during retraction of the foreskin, making it difficult to pass the catheter. The excisional biopsy of the right testicular nodule was sent for pathological examination, and the final diagnosis was chronic granulomatous inflammation with eosinophilia around Schistosoma mansoni eggs.

DISCUSSION

Although schistosomiasis is endemic in many countries, testicular involvement is extremely rare. In an autopsy study in an endemic area in Brazil, testicular involvement was found in 3.2% of the schistosomiasis cases, indicating that these lesions are commonly subclinical ¹ . Testicular involvement is attributed to the migration of eggs through venous channels between the internal spermatic and mesenteric veins ² , inducing an immune response with granuloma formation and associated fibrotic changes ^{3 4} . This lesion can mimic a malignant lesion presenting with painless small solid nodules.

Echographically, the schistosomal lesion appears as a well delimited solid testicular mass with a heterogeneous echotexture or hypoechogenicity and shows increased vascularity on color Doppler flow imaging, which is an appearance identical to that of most testicular malignancies ^{3 5 6} .

Magnetic resonance imaging might be better than US to show intratesticular abnormalities; however, neither technique allows differentiation between benign and malignant disorders ⁷ .

There are few studies describing MRI findings of testicular schistosomiasis (TS) in the literature. Lopes et al ⁸ described, in a case report, an irregular tunica albuginea signal on the posterior side of the testis without evidence of a focal nodular lesion ⁸ . Hassan et al reported an extratesticular mass of low signal intensity on T2-weighted imaging, indicating a fibrous tissue component. No intratesticular masses of abnormal signal intensity or enhancement were present ² . In our case, we report a solid and hypervascularized intratesticular nodule associated with bilateral ectasia of the veins of the pampiniform plexus.

The recognition of TS as a differential diagnosis for testicular tumors is crucial to avoid unnecessary orchiectomies ⁹ . The authors believe that the indication for radical orchiectomy should be carefully reviewed to avoid unnecessary invasive surgeries, especially in patients of fertile age and in schistosomiasis endemic areas. In this context, a partial orchiectomy from the inguinal approach with perioperative freezing can be a safe and effective approach for both diagnosis and treatment of benign lesions; it also allows conversion to a radical orchiectomy for neoplasms diagnosed during freezing.

References

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• ⁹Periyasamy P, Subramaniam SR, Rajalingham S. An increasingly notorious mimicker of testicular tumours; crossing borders. BMJ Case Rep 2011; pii: bcr0920114816. doi: 10.1136/bcr.09.2011.4816.

Publication Dates

• Publication in this collection
  Aug 2015

History

• Received
  27 Oct 2014
• Accepted
  11 May 2015