Dear Editor,
We would like to comment on the publication “2022 Mpox (Monkeypox) outbreak: a concise review focused on new features of dermatological lesions”.11 Pinto-Pulido EL, Fernández-Parrado M, Rodríguez-Cuadrado FJ. 2022 Mpox (monkeypox) outbreak: a concise review focused on new features of dermatological lesions. An Bras Dermatol. 2023. Pinto-Pulido et al. Pinto-Pulido et al. pointed out that in addition to epidemiological alterations, clinical variations from the clinical picture previously described in endemic areas have also been recorded. It is unclear if these modifications are brought on by genetic changes in the virus, a unique method of transmission, unique baseline traits of affected patients in comparison to those of endemic nations, or, more likely, a combination of all these elements. Because pseudopustules with a necrotic-hemorrhagic center are uncommon in other dermatological illnesses, Pinto-Pulido et al. noted that a thorough dermatological description of lesions is necessary for a correct diagnosis. We all agree that the key to a successful early diagnosis of monkeypox is a thorough dermatological examination. However, it is challenging to diagnose if there is an atypical appearance, no fever, or no skin lesion at the initial presentation.22 Mungmunpuntipantip R, Wiwanitkit V. Letter to editor: human monkeypox and the atypical outbreak. Zhongguo Dang Dai Er Ke Za Zhi. 2022;24:1178-9. Atypical clinical skin lesions can occasionally occur and can be challenging to distinguish from other frequent dermatological issues.22 Mungmunpuntipantip R, Wiwanitkit V. Letter to editor: human monkeypox and the atypical outbreak. Zhongguo Dang Dai Er Ke Za Zhi. 2022;24:1178-9. Moreover, there are still issues with both false positive and negative results in the laboratory diagnosis of monkeypox using PCR.33 Tan NK, Madona CP, Taylor JF, Fourali LH, Sehmi JK, Stone MJ, et al. Performance evaluation of the Viasure PCR assay for the diagnosis of monkeypox: a multicentre study. J Clin Virol. 2023;158:105350. In questionable cases, a thorough clinical history taking, reexamination, and reanalysis of the clinical samples are required.
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Financial supportNone declared.
References
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1Pinto-Pulido EL, Fernández-Parrado M, Rodríguez-Cuadrado FJ. 2022 Mpox (monkeypox) outbreak: a concise review focused on new features of dermatological lesions. An Bras Dermatol. 2023.
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2Mungmunpuntipantip R, Wiwanitkit V. Letter to editor: human monkeypox and the atypical outbreak. Zhongguo Dang Dai Er Ke Za Zhi. 2022;24:1178-9.
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3Tan NK, Madona CP, Taylor JF, Fourali LH, Sehmi JK, Stone MJ, et al. Performance evaluation of the Viasure PCR assay for the diagnosis of monkeypox: a multicentre study. J Clin Virol. 2023;158:105350.
Publication Dates
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Publication in this collection
28 Aug 2023 -
Date of issue
Sep-Oct 2023
History
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Received
20 Mar 2023 -
Accepted
03 Apr 2023 -
Published
22 May 2023