A national study on the use of opioid analgesics in dentistry

Abstract

The aim of this study was to assess the frequency of opioid analgesics prescribed by Brazilian dentists, potential regional differences and their association with socioeconomic and health-related factors. Data for all opioid prescriptions by dentists was obtained from the 2012 database of the National Controlled Substances Management System, regulated by the Brazilian Health Surveillance Agency. The number of defined daily doses (DDD) and DDDs per 1,000 inhabitants per day for each Brazilian state were calculated as the primary outcomes. DDDs were compared by regions and Brazilian states. Spearman’s rho correlation coefficient was used to determine the influence of the states’ characteristics, such as the Human Development Index; poverty; education; number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; good or very good oral health; number of pharmaceutical establishments per 100,000/inhabitants; and ability to get all prescribed medications. Data analysis was performed using IBM SPSS Statistics 25.0. A total of 141,161 prescriptions for opioids analgesics by 36,929 dentists were recorded, corresponding to 658,855 doses of opioids dispensed in 2012. The most commonly dispensed opioids were codeine associated with paracetamol (83.2%; n = 117,493). The national DDDs per 1,000 inhabitants per day was 0.0093 (range: 0.0002-0.0216). DDD per 1,000 inhabitants per day was positively associated to visits to dentists (rs = 0.630; P < 0.001) and inversely associated to poverty (rs = -0.624; p = 0.001). There are significant differences in opioid prescriptions in dentistry among the Brazilian states. These differences may be associated with non-clinical factors.

Analgesics, Opioid; Prescription Drugs; Dentistry; Healthcare Disparities; Dental Care

Introduction

The management of pain is very common in the dental practice. ¹ When drug therapy is required, opioid analgesics are not usually the first choice, however they should be considered as an alternative in specific cases. ² , ³ , ⁴ These include situations where acetaminophen or a nonsteroidal anti-inflammatory drug (NSAID) are contraindicated. The World Health Organisation reinforces that opioid analgesics are an additional medication to other first-choice non-opioids, in cases where they do not act enough. ⁵

Opioid use has increased in dental practice in the last few decades. ⁶ Studies also report an increased prevalence of opioid addiction and a parallel increase in opioid overdose deaths. ⁷ As one might expect, prescribers play an important role in controlling these addiction problems. ⁸ However, on the other hand, millions of people worldwide suffer from untreated pain, this great need for pain control is found in the developing world, especially among the poor, elderly, mentally ill, children, women, and racial/ethnic minorities. ⁹ The use of opioid analgesics has increased in different geographic areas and in different scenarios. However they coexist with a great concern in some regions where with excessive opioid use, while other regions experience difficulty accessing this class of drugs. ¹⁰

Rational drug therapy aims to select pain-relief or pain-control drugs while minimising possible adverse effects. National drug surveillance systems may collaborate with actions promoting rational drug use. Some healthcare systems worldwide have databases that enable monitoring and comparisons between various pharmaceutical drugs usage. These drug-dispensing data enable the identifying of patterns of drug prescription adopted by healthcare professionals. In Brazil, opioid analgesics are controlled by the Brazilian Health Regulatory Agency (Agência Nacional de Vigilância Sanitária – Anvisa) and according to current legislation these drugs require a prescription to be dispensed. ¹¹

In Brazil, accessing these medications involves a sequence of events. Firstly, consultation with a dentist, then, the dentist prescribes the opioid analgesic when it is needed and finally access to medication. ¹¹ Socioeconomic conditions and cost of opioids can also interfere in the access to medication. ¹²

Brazil has an extensive area, with different socioeconomic and health characteristics among regions. Current studies demonstrate associations between social and economic inequalities and health, thus monitoring health inequalities has become an essential feature of measuring national health progress and development that can guide public policies. ¹³

Socioeconomic factors, such as poverty, Human Development Index (HDI), education and health-related factors, such as the number of dentists, access to oral health services and to medicines could be associated to opioid use in the population. Considering the potential impact of opioid use on population, the relevant role of prescribers in the rational use and the few epidemiological studies exploring the role of dentistry on opioid prescriptions in Brazil, the objective of this study was to provide national data on the use of opioid analgesic in dentistry and to explore its association with socioeconomic and health-related factors. The null hypothesis was that socioeconomic and health-related factors would not affect the use of opioid analgesic in dentistry.

Methodology

This cross-sectional study investigated the opioid analgesic prescription by Brazilian dentists dispensed during the year 2012. The database was provided by the National Controlled Substances Management System ( Sistema Nacional de Gerenciamento de Produtos Controlados – SNGPC) of Brazilian Health Regulatory Agency, which surveys private drugstores. This study was approved by the Ethics Committee of the Federal University of Minas Gerais ( Universidade Federal de Minas Gerais - UFMG) under number CAAE-24383913.9.0000.5149.

All opioid analgesics prescriptions dispensed by Brazilian pharmacies in 2012 were made available by SNGPC for data analysis. The following variables were collected from the original database: prescribed drugs, drug presentation and quantity prescribed of each drug, Brazilian state where the product was sold and the dentist’s code. The drugs were classified according to the Anatomical Therapeutic Chemical (ATC) Classification System of the World Health Organisation (WHO) Collaborating Centre for Drug Statistics and Methodology. ¹⁴

For population analysis, a statistical measure of drug consumption that enables researchers to assess drug consumption trends and to perform comparisons between population groups is the defined daily dose (DDD). Each formulation (and per route of administration is assigned a daily dose by WHO Center, that is the mg (or other units) per day an adult needs for the desired therapeutic effect, based on the current data and guidelines. Then, we calculated i) the number of DDDs for each prescribed opioid and ii) the DDDs per 1,000 inhabitants per day for each Brazilian state: a) The number of DDDs was obtained with the multiplication of (aa) number of packages by (ab) pharmaceutical forms’ number per package and (ac) drug active ingredients’ quantity per pharmaceutical form. Lastly, the product of this multiplication was divided by the DDD of each drug according to ATC; b) The “DDDs per 1,000 inhabitants per day” provides an estimate of the proportion of the population within a defined area treated daily with a certain drug. The following formula was used to calculate the DDDs per 1,000 inhabitants per day: (number of DDDs x 1,000) / (inhabitants x 365). ¹⁴ , ¹⁵ , ¹⁶

Multiple sources of data were used to identify Brazilian states socioeconomic and health-related factors, The Atlas of Human Development in Brazil (Atlas de Desenvolvimento Humano no Brasil) provided the HDI, the indicator of poverty and education. ¹⁷ The HDI was proposed by the United Nations Development Programme and combines three aspects for the life: the opportunity for a long and healthy life (health); the access to knowledge (education); and income. For health information, the nationwide household National Health Survey (Pesquisa Nacional de Saúde – PNS) provides important state level information, such as dental visits, dental care plan, proportion of population that considers their oral health as good or very good and ability to get all prescribed medications. ¹⁸ The number of dentists, by Brazilian state, was provided by the Federal Council of Dentistry ¹⁹ (Conselho Federal de Odontologia – CFO), and the number of inhabitants was obtained from the Brazilian Institute of Geography and Statistics ¹⁵ (Instituto Brasileiro de Geografia e Estatística – IBGE). The number of pharmaceutical establishments per 100,000 inhabitants (registered in SNGPC) was supplied by the Brazilian Health Regulatory Agency ¹¹ ( Table 1 ).

Table 1
List of variables.

Variables	Definition	Source
Socioeconomic
Poverty	Proportion of individuals with per capita household income less than $145.28 (1$=1.76 Brazilian Reais)	Atlas of Human Development in Brazil
Human Development Index	Geometric mean of the three dimensions: longevity, education and income. Range from 0 to 1.	Atlas of Human Development in Brazil
Education	Average years of study for persons with at least 25 years of age	Atlas of Human Development in Brazil
Health – Oral Health
Number of dentists per 100,000 inhabitants	Total number of dentists registered on Federal Council of Dentistry	Federal Council of Dentistry
Visit to dentists	Proportion of population who visited the dentist in the last 12 months	Pesquisa Nacional de Saúde
Dental care plan	Proportion of population with some plan only for dental care	Pesquisa Nacional de Saúde
Consider oral health good or very good	Proportion of population with 18 years of age or older that consider their oral health as good or very good	Pesquisa Nacional de Saúde
Health - Medications
Number of pharmaceutical establishments per 100,000 inhabitants	Total number of pharmaceutical establishments divided by100,000 inhabitants	Brazilian Health Regulatory Agency
Ability to get all medications prescribed	Proportion of population that were able to obtain all the drugs prescribed in their last health consultation	Pesquisa Nacional de Saúde

Taking into account the events involved with acquiring opioid analgesics by a population, variables were organised into three groups ( Table 1 ):

1. Socioeconomics: poverty; HDI; and education;

2. Health – Oral Health: number of dentists per 100,000 inhabitants; visit to the dentist; dental care plan; and good or very good oral health;

3. Health – Medications: number of pharmaceutical establishments per 100,000 inhabitants; and ability to get all prescribed medications.

A descriptive statistical analysis was performed, including the calculation of proportions and measures of central tendency and variability. To understand whether these state-level covariates were associated to values of DDDs per 1,000 inhabitants per day, non-parametric correlation tests were performed (Spearman’s rho correlation coefficient, 2-tailed – r _s ). Data analysis was performed using the IBM SPSS Statistics 25.0 statistical software.

Results

A total of 141,161 prescriptions for opioids analgesics were made by 36,929 dentists. A total of 160,627 packages were dispensed (90.3% with 1 package). The frequency of opioid prescription type was codeine associated to paracetamol n = 117,493 (83.2%), tramadol n = 13,562 (9.6%), codeine and other non-opioid analgesics n = 4,308 (3.1%), tramadol and paracetamol n = 4,297 (3.0%), codeine n = 1,056 (0.7%), oxycodone n = 390 (0.3%), morphine n = 50 (<0.001%), fentanyl n = 4 (<0.001%) and hydromorphone n = 1 (<0.001%). The national mean of opioid prescriptions by dentists was 3.82 prescriptions (50.6% of dentists prescribed at least 12 times during the year). These data are not tabulated.

Brazilian state-level results show that the prescription frequencies ranged from 93 to 39,105 prescriptions, the number of opioid packages ranged from 108 to 46,977, the number of DDD ranged from 441.9 to 18,4233.9 and the mean number of dentist-prescribed prescriptions ranged from 1.99 to 5.06 ( Table 2 ).

Table 2
Descriptive statistics on the opioid analgesics prescribed by Brazilian dentists dispensed by Brazilian state in 2012.

Region	Brazilian state	Frequency of prescription a	Prescription per dentist b mean (min-max)	Number of packages	Number of DDDs
Midwest	DF	1430 (1.0%)	3.43 (1-198)	1691	7464.0
	GO	2210 (1.6%)	3.63 (1-92)	2607	11227.9
	MS	768 (0.5%)	3.14 (1-123)	837	2850.1
	MT	617 (0.4%)	3.94 (1-61)	680	2447.3
North	AC	93 (0.1%)	2.58 (1-27)	108	441.9
	AM	230 (0.2%)	2.95 (1-46)	252	1216.9
	AP	133 (0.1%)	4.26 (1-31)	138	635.0
	PA	1759 (1.2%)	4.07 (1-72)	1927	7808.0
	RO	203 (0.1%)	3.14 (1-43)	222	878.7
	RR	164 (0.1%)	2.88 (1-20)	229	833.3
	TO	266 (0.2%)	2.95 (1-37)	300	1511.3
Northeast	AL	677 (0.5%)	3.01 (1-42)	737	2984.5
	BA	14311 (10.1%)	5.06 (1-157)	15076	62575.0
	CE	1929 (1.4%)	3.26 (1-124)	2207	9699.9
	MA	109 (0.1%)	2.12 (1-18)	142	587.0
	PB	785 (0.6%)	2.99 (1-98)	990	3804.0
	PE	1770 (1.3%)	2.90 (1-85)	2099	8766.2
	PI	177 (0.1%)	2.75 (1-50)	223	756.7
	RN	1018 (0.7%)	4.07 (1-81)	1112	4385.0
	SE	753 (0.5%)	3.28 (1-77)	818	3245.8
South	PR	11430 (8.1%)	3.55 (1-144)	12604	53943.3
	RS	17970 (12.7%)	4.27 (1-203)	20275	85045.5
	SC	8210 (5.8%)	3.84 (1-188)	9253	38934.4
Southeast	ES	468 (0.3%)	1.99 (1-24)	617	2489.9
	MG	30072 (21.3%)	4.78 (1-340)	32594	137559.6
	RJ	4504 (3.2%)	2.43 (1-160)	5912	22529.4
	SP	39105 (27.7%)	3.36 (1-452)	46977	184233.9

• ^a This analysis was based on the availability of the drug for the patient according to the SNGPC registry; ^b Dentists who prescribed according to Brazilian state of professional registration.

The socioeconomic and health indicators differences between the Brazilian regions are presented in Table 3 . The North and Northeast states’ proportions of individuals with per capita household income less than $145.28 ranged from 27.4% to 56.9%, while South, Southeast and Midwest states’ values ranged from 8.0% to 20.2% of the population. The proportion of the population that visited the dentist in the last 12 months in states of the North and Northeast varied from 28.5% to 43.7%, while in states of South, Southeast and Midwest region results ranged from 39.2% to 54.1% of the population. The proportion of individuals that were able to obtain all the drugs prescribed in the last health consultation ranged from 63.6% (RR – North) to 86.9% (ES – Southeast).

Table 3
Socioeconomic, oral health and medication indicators by Brazilian states.

Region	State	Poverty	HDI	Education	Number of dentists per 100,000/inhabitants	Visit to dentists	Dental care plan	Consider oral health good or very good	Number of pharmaceutical establishments per 100,000/inhabitants	Ability to get all medications prescribed
Midwest	DF	15.0%	0.827	10.8	233	51.9%	6.8%	74.0%	33	80.2%
	GO	16.6%	0.745	8.6	149	42.4%	6.2%	67.7%	52	84.4%
	MS	15.5%	0.746	8.7	149	47.5%	2.5%	71.2%	33	85.9%
	MT	19.0%	0.755	8.4	137	41.8%	4.7%	64.6%	38	77.4%
North	AC	42.3%	0.696	8.1	84	36.1%	1.4%	64.1%	24	78.1%
	AM	42.9%	0.679	8.8	98	42.1%	4.8%	66.3%	7	73.4%
	AP	40.5%	0.707	9.2	90	30.7%	3.9%	66.4%	13	79.7%
	PA	43.5%	0.659	7.7	61	30.1%	3.4%	56.1%	12	76.4%
	RO	27.4%	0.698	7.9	117	36.3%	2.1%	58.3%	34	82.6%
	RR	37.0%	0.729	9.6	137	39.9%	2.0%	65.9%	17	63.6%
	TO	34.0%	0.711	7.9	132	36.0%	2.4%	58.9%	27	73.9%
Northeast	AL	50.5%	0.644	6.6	84	34.8%	3.4%	57.0%	21	74.7%
	BA	44.0%	0.682	7.4	78	35.9%	5.4%	57.7%	18	81.8%
	CE	44.2%	0.704	7.2	75	37.3%	3.2%	61.8%	15	81.3%
	MA	56.9%	0.650	6.7	57	28.5%	1.6%	50.7%	11	79.1%
	PB	40.8%	0.682	7.3	111	43.6%	3.2%	60.0%	27	82.1%
	PE	39.8%	0.694	7.7	83	42.5%	3.2%	61.7%	18	83.0%
	PI	44.9%	0.664	6.6	92	36.9%	1.0%	57.9%	20	74.5%
	RN	36.8%	0.715	7.8	106	43.7%	3.9%	61.5%	29	78.5%
	SE	39.7%	0.688	7.4	85	40.2%	4.2%	61.8%	22	84.4%
South	PR	13.9%	0.774	8.9	165	49.7%	6.8%	71.3%	41	86.1%
	RS	14.4%	0.757	8.7	158	52.7%	3.9%	73.4%	42	84.5%
	SC	8.0%	0.797	9.1	167	54.1%	4.6%	71.5%	42	83.4%
Southeast	ES	18.7%	0.769	8.8	141	39.2%	4.3%	66.3%	39	86.9%
	MG	20.2%	0.754	8.3	162	43.2%	3.2%	69.6%	39	83.0%
	RJ	18.6%	0.762	9.7	183	42.2%	7.2%	71.6%	24	82.8%
	SP	11.3%	0.808	9.7	190	53.9%	8.0%	74.1%	30	83.0%

• Sources: Atlas of Human Development in Brazil, PNS, IBGE, CFO and Anvisa.

There was a large difference between the prescription rates among Brazilian states. The national DDDs per 1,000 inhabitants per day was 0.0093, with the lowest value being 0.0002 (MA – Northeast) and the highest value 0.0216 (RS – South). There are clearly two groups within the country. The first group with seven states that presented high prescription rates of opioid analgesics dispensed to patients (range: 0.0077-0.0216 DDDs per 1,000 inhabitants per day) and the second group with twenty states that had low prescription rates (range: 0.0002-0.0050). States with high values correspond to the seven states with a darker colour (RS, MG, SC, PR, BA, SP, DF) on the map, which illustrates how these states are distributed within the Brazilian territory. Five states with high prescriptions rates are in the South and Southeast regions ( Figure ).

Figure
Distribution of DDDs per 1,000 inhabitants per day by Brazilian states.

Table 4 shows the result of factors associated to the quantities of opioid analgesics sold in Brazilian states. All analysed covariates were associated to differences in DDD values in state level analysis (n = 27; p < 0.05). DDD per 1,000 inhabitants per day was inversely associated to poverty and positively associated to the other factors (n = 27; p < 0.05). In the socioeconomic category, the factor that had the most significant association with the amount of opioid analgesics dispensed was poverty (r _s = - 0.624; p = 0.001). In the oral health category, visiting the dentists in the last 12 months was the most significant factor (r _s = 0.630; p < 0.001). Finally, in the medications category, the number of pharmaceutical establishments per 100,000/inhabitants was associated to the quantities of opioids (r _s = 0.505; p = 0.007).

Table 4
Correlation between socioeconomic/health factors and quantities of opioid analgesics dispensing in Brazilian states, 2012.

Covariates	All Brazilian states (n=27)		States with low a DDD (n = 20)		States with high a DDD (n = 7)
	Spearman’s correlation coefficient	p-value (2-tailed)	Spearman’s correlation coefficient	p-value (2-tailed)	Spearman’s correlation coefficient	p-value (2-tailed)
Socioeconomic
Poverty	-0.624	0.001	-0.489	0.029	-0.036	0.939
Human Development Index	0.603	0.001	0.442	0.051	-0.571	0.180
Education	0.412	0.033	0.266	0.258	-0.571	0.180
Health - oral health
Number of dentists per 100,000/inhabitants	0.576	0.002	0.388	0.091	-0.607	0.148
Visit to dentists	0.630	< 0.001	0.466	0.038	0.036	0.939
Dental care plan	0.493	0.009	0.344	0.137	-0.847	0.016
Consider oral health good or very good	0.585	0.001	0.394	0.086	-0.357	0.432
Health - medicines
Number of pharmaceutical establishments per 100,000/inhabitants	0.505	0.007	0.247	0.294	0.721	0.068
Ability to get all medications prescribed	0.484	0.010	0.251	0.285	0.649	0.115

• ^a The cut-off point was the third quartile. It refers to an internal comparison (within the Brazilian territory), we are not comparing these values with of other countries.

Table 4 also shows how covariates act when the data are stratified according to the value of DDDs per 1,000 inhabitants per day. States were categorised as “low” and “high”, with the cut-off point being the third quartile value. States with DDDs above the third quartile were classified as high (n = 7) while states below the third quartile were classified as low (n = 20). This analysis is important because there was a large difference between the prescription rates. When the data are stratified, in Brazilian states with low prescription rates (n = 20), the association was significant with the vulnerability to poverty (r _s = - 0.489; p = 0.029) and visit to dentists (r _s = 0.466; p = 0.038). In Brazilian states with high prescription rates (n = 7), the significant association was with dental care plan (r _s = - 0.847; p = 0.016).

When we evaluate all states, the correlation coefficients were positive for HDI, education, number of dentists per 100,000/inhabitants and dental care plan. This is maintained in the stratified analysis where states presented low prescription rates. But in states with high prescription rates, the correlation coefficients were negative, thus, a better HDI, more years of study and more dentists for the population are associated to lower DDD values. Vulnerability to poverty was consistently negatively associated to DDD. Regarding to dental care plan, in the analysis with all states (n = 27) and states with low prescription rates (n = 20), the correlation coefficient was positive, but in the states with high prescription rates was negative and significant (r _s = - 0.847; p = 0.016). It is possible to see that factors can act differently when states are stratified according to prescription rates ( Table 4 ).

Discussion

This study found a low amount of opioids prescribed by Brazilian dentists, with different rates among states. Socioeconomic and health-related factors influenced the quantities of opioids dispensing in Brazilian states.

The quantities of opioid analgesics prescribed by dentists and dispensed was low, mainly when compared to the medical prescriptions of some countries. ²⁰ - ²³ These data are in agreement with a recently published study, which found lower values of opioid use in South America and addressed possible barriers to access to these drugs. ¹⁰ Most of the prescriptions were for a short period of time, because 90.3% of prescriptions had only one package and 62.3% with four DDD by prescription (four days of treatment). Short-term use was gratifying to find because, of a decreased risk of chemical dependence (opioid misuse or abuse) in this population. Besides the risk of chemical dependence, opioid analgesics may increase or decrease the potency of other drugs. Opioids may interact with some antibiotics, benzodiazepines, centrally acting sedative drugs, antidepressants and alcohol, they should be prescribed with caution to individuals with obstructive sleep apnoea. ²⁴ , ²⁵ There is some evidence that opioid users are at a higher risk of traffic accidents. ²⁶ A systematic review on prescriber behaviour identified five ways in which opioid prescribers’ behaviour may have played a role in increased opioid-related mortality: prescribing more opioids, prescribing higher doses of opioids, prescribing oxycodone, prescribing methadone and prescribing at high volumes. ⁸

DDDs per 1,000 inhabitants per day demonstrated atypical distributions within the Brazilian territory, with large variations between the largest and smallest state values and with the highest values concentrated in southern and south-eastern states. We identify two types of dental opioid prescription regions in the Brazilian states. A small group of states with high dispensing rates and a large group with low dispensing rates. One possible explanation for this divergence could be the diversity found within the territory, where some regions present better indicators than others. Brazilian regions experience very different socioeconomic indicators, dental access and access to medications. As seen in this study, regions with better socioeconomic indicators, such as south and southeast regions, also show greater access to dentists and more prescriptions. The study results are in agreement with previous studies which also showed that these regions have better indicators. ²⁷ , ²⁸ , ²⁹ Differences in the quantities of opioid analgesics dispensed may reflect the existence of differences in access to these drugs between states. Most Brazilian states have relatively low dispensing rates of opioid analgesics for dental care purposes. However, the seven states with the highest DDDs per 1,000 inhabitants per day accumulated 86.8% of the total prescriptions.

All analysed variables were associated to differences in DDD values in the state level analysis (n = 27), but it is important to point out the association of the quantity of opioids prescribed with access to the dentist in the last 12 months and poverty. The Brazilian states with increased access to the dentists, presented a higher amount of sales of opioid analgesics. States with the highest proportion of people living with less than 145.28 US dollar presented lower sales of opioid analgesics. It would be expected that regions with worse socioeconomic and oral health indicators demand a greater use of medications. Hence the results suggest “the inverse care law” ³⁰ , ³¹ may be present, where poverty can be considered a barrier to access to medications in states with low and high prescription rates.

The correlation coefficients, however, present different results when the data are stratified according to the prescription rates of “low” or “high”. In some cases, there was inversion of the relationship direction. In states with high rates of prescriptions, a better HDI, more years of study and more dentists for the population are associated to lower DDD values. A possible explanation for the differences found regarding the dental care plan would be that in states with worse socioeconomic and health indicators having a dental care plan may be a proxy of better socioeconomic status. But possibly in states with better socioeconomic and health indicators, having only the dental care plan would not be a good indicator of better socioeconomic status. ³² , ³³ Recalling that, as described in the methodology, this covariate concerns population proportion with some plan only for dental care, that is, we are not analysing medical plan.

The fact that the oral health conditions of the seven states with high opioid prescription rates are different from the profile of the other states could explain the differences between the two groups. ²⁸ , ²⁹ The use of health services results from several interacting factors, but socioeconomic factors play an essential role on the provision of health services and the possibility of the population using this health service. ³⁴ , ³⁵ , ³⁶ Another explanation could be the difference in the quality of the oral health care and the knowledge about opioid prescription among dentists in these two groups of states. ²⁹ Oral diseases disproportionally affect disadvantaged populations placing an additional disease burden on these populations. Thus, the distribution of the use of these drugs according to region reflects existing inequalities among society produced within the social framework. As well as access to health services, oral health and general health are directly related to socioeconomic factors. ³⁴ , ³⁵ , ³⁶

It is not possible to affirm if there was misuse of opioids in states with higher rates. A separate study at the individual level with access to the reason for prescription is required. However, in population terms, the results suggest that access to this class of drugs can be favoured or opposed according to non-clinical factors. Regions with the highest demands in oral health ³⁷ were composed of states with lower DDDs. Thus, evaluating the distribution of DDDs according to region can help understand how different approaches and strategies may be necessary within the same national territory. There may be certain barriers to access opioids in regions with extremely low values ¹⁰ , which are not desirable, since pain can negatively impact quality of life. In contrast, high values may expose the population to risks of adverse effects. ⁷ , ⁸ , ³⁸ Given this, the surveillance system working together with universities and regional dental councils plays an important role in monitoring these regional differences and thus contributing to the rational use of opioids by dentists.

Regarding the limitations, the entire process of selling and dispensing these drugs is monitored by SNGPC, but it was not possible to identify the reason for the prescription of these drugs in the system. Brazilian legislation does not require that the International Classification of Diseases (ICD) and prescription purpose data to be included in prescription orders of opioid analgesics. The use of secondary data in studies may have methodological problems of data identification and reliability. Results indicated the need for further studies and the format of the current database limited some analysis. It is also important to point out that despite we analysed the most up-to-date dataset available for dental prescriptions from the Brazilian Health Regulatory Agency, some increasing in opiate consumption in most recent years may occur, as identified in Brazil ³⁹ other countries. ⁸

In conclusion, the amount of opioid analgesics prescribed by Brazilian dentists showed large differences among Brazilian states and those differences may be associated to non-clinical factors. The clinical implications of these findings are that may be necessary to formulate public policies with different approaches for the country because the regional differences. Prescription drug monitoring programs and continuing education for the prescriber could be implemented and increased in the country. Further studies will be necessary to identify individually related factors to opioids prescribed by dentists.

Acknowledgements

We thank the Agência Nacional de Vigilância Sanitária – ANVISA for providing access to the database, Boston University Henry M. Goldman School of Dental Medicine for all support provided during the internship of Lino PA, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES through the Programa de Doutorado-sanduíche no Exterior – PDSE (88881.133270/2016-01) and the Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (307617/2015-7).

References

• ¹ Kassebaum NJ , Smith AG , Bernabé E , Fleming TD , Reynolds AE , Vos T , et al . Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, and risk factors . J Dent Res . 2017 Apr ; 96 ( 4 ): 380 - 7 . https://doi.org/10.1177/0022034517693566
  » https://doi.org/10.1177/0022034517693566
• ² Derry S , Moore RA , McQuay HJ . Single dose oral codeine, as a single agent, for acute postoperative pain in adults . Cochrane Database Syst Rev . 2010 Apr ;( 4 ): CD008099 . https://doi.org/10.1002/14651858.CD008099.pub2
  » https://doi.org/10.1002/14651858.CD008099.pub2
• ³ Santini MF , Rosa RA , Ferreira MB , Fischer MI , Souza EM , Só MV . Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial . J Appl Oral Sci . 2017 Sep-Oct ; 25 ( 5 ): 551 - 8 . https://doi.org/10.1590/1678-7757-2016-0407
  » https://doi.org/10.1590/1678-7757-2016-0407
• ⁴ Hempenstall K , Nurmikko TJ , Johnson RW , A’Hern RP , Rice AS . Analgesic therapy in postherpetic neuralgia: a quantitative systematic review . PLoS Med . 2005 Jul ; 2 ( 7 ): e164 . https://doi.org/10.1371/journal.pmed.0020164
  » https://doi.org/10.1371/journal.pmed.0020164
• ⁵ World Health Organization – WHO . Persisting pain in children package: WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses . Geneva : World Health Organization ; 2012 [ cited 2019 Feb 10 ] Available from: http://apps.who.int/iris/bitstream/handle/10665/44540/9789241548120_Guidelines.pdf;jsessionid=5E480BD0B44510DE9611C635D8E5C6E2?sequence=1
  » http://apps.who.int/iris/bitstream/handle/10665/44540/9789241548120_Guidelines.pdf;jsessionid=5E480BD0B44510DE9611C635D8E5C6E2?sequence=1
• ⁶ Hollingworth SA , Chan R , Pham J , Shi S , Ford PJ . Prescribing patterns of analgesics and other medicines by dental practitioners in Australia from 2001 to 2012 . Community Dent Oral Epidemiol . 2017 Aug ; 45 ( 4 ): 303 - 9 . https://doi.org/10.1111/cdoe.12291
  » https://doi.org/10.1111/cdoe.12291
• ⁷ Morin KA , Eibl JK , Franklyn AM , Marsh DC . The opioid crisis: past, present and future policy climate in Ontario, Canada . Subst Abuse Treat Prev Policy . 2017 Nov ; 12 ( 1 ): 45 . https://doi.org/10.1186/s13011-017-0130-5
  » https://doi.org/10.1186/s13011-017-0130-5
• ⁸ King NB , Fraser V , Boikos C , Richardson R , Harper S . Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review . Am J Public Health . 2014 Aug ; 104 ( 8 ): e32 - 42 . https://doi.org/10.2105/AJPH.2014.301966
  » https://doi.org/10.2105/AJPH.2014.301966
• ⁹ King NB , Fraser V . Untreated pain, narcotics regulation, and global health ideologies . PLoS Med . 2013 ; 10 ( 4 ): e1001411 . https://doi.org/10.1371/journal.pmed.1001411
  » https://doi.org/10.1371/journal.pmed.1001411
• ¹⁰ Berterame S , Erthal J , Thomas J , Fellner S , Vosse B , Clare P , et al . Use of and barriers to access to opioid analgesics: a worldwide, regional, and national study . Lancet . 2016 Apr ; 387 ( 10028 ): 1644 - 56 . https://doi.org/10.1016/S0140-6736(16)00161-6
• ¹¹ Agência Nacional de Vigilância Sanitária – Anvisa . Sistema Nacional de Gerenciamento de Produtos Controlados – SNGPC . Brasília, DF : Agência Nacional de Vigilância Sanitária ; 2018 cited 2018 May 5 ]. Available from: http://portal.anvisa.gov.br/sngpc
  » http://portal.anvisa.gov.br/sngpc
• ¹² Lima L , Sweeney C , Palmer JL , Bruera E . Potent analgesics are more expensive for patients in developing countries: a comparative study . J Pain Palliat Care Pharmacother . 2004 ; 18 ( 1 ): 59 - 70 . https://doi.org/10.1080/J354v18n01_05
  » https://doi.org/10.1080/J354v18n01_05
• ¹³ Landmann-Szwarcwald C , Macinko J . A panorama of health inequalities in Brazil . Int J Equity Health . 2016 Nov ; 15 ( 1 ): 174 . https://doi.org/10.1186/s12939-016-0462-1
  » https://doi.org/10.1186/s12939-016-0462-1
• ¹⁴ World Health Organization – WHO . Collaborating Centre for Drug Statistics Methodology. ATC classification and DDD assignment . Oslo : World Health Organization ; 2017 [ cited 2018 Mar 3 ]. Available from: https://www.whocc.no/
  » https://www.whocc.no/
• ¹⁵ Instituto Brasileiro de Geografia e Estatística – IBGE . Population 2012 . Rio de Janeiro : Instituto Brasileiro de Geografia e Estatística ; 2018 [ cited 2018 Feb 2 ]. Available from: https://www.ibge.gov.br/estatisticas/sociais/populacao.html
  » https://www.ibge.gov.br/estatisticas/sociais/populacao.html
• ¹⁶ Hutchinson JM , Patrick DM , Marra F , Ng H , Bowie WR , Heule L , et al . Measurement of antibiotic consumption: a practical guide to the use of the anatomical thgerapeutic chemical classification and definied daily dose system methodology in Canada . Can J Infect Dis . 2004 Jan ; 15 ( 1 ): 29 - 35 . https://doi.org/10.1155/2004/389092
  » https://doi.org/10.1155/2004/389092
• ¹⁷ Programa das Nações Unidas para o Desenvolvimento , Fundação João Pinheiro , Instituto de Pesquisa Econômica Aplicada . Atlas do desenvolvimento humano no Brasil . Brasília, DF : Programa das Nações Unidas para o Desenvolvimento ; 2013 [ cited 2018 mar 03 ]. Available from: http://www.atlasbrasil.org.br/2013/
  » http://www.atlasbrasil.org.br/2013/
• ¹⁸ Instituto Brasileiro de Geografia e Estatística – IBGE . Pesquisa Nacional de Saúde 2013: Percepção do estado da saúde, estilos de vida e doenças crônicas: Brasil, grandes regiões e unidades da federação . Rio de Janeiro : Instituto Brasileiro de Geografia e Estatística ; 2017 [ cited 2018 Mar 3 ]. Available from: https://ww2.ibge.gov.br/home/estatistica/populacao/pns/2013/
  » https://ww2.ibge.gov.br/home/estatistica/populacao/pns/2013/
• ¹⁹ cfo.org.br . [ homepage from the Internet ]. Bras?lia: Brasil. Conselho Federal de Odontologia - CFO. Relat?rios do CFO . Sistema de Cadastro ; 2017 . Available from: http://cfo.org.br/website/
  » http://cfo.org.br/website/
• ²⁰ Ponizovsky AM , Marom E , Zeldin A , Cherny NI . Trends in opioid analgesics consumption, Israel, 2000-2008 . Eur J Clin Pharmacol . 2011 Feb ; 67 ( 2 ): 165 - 8 . https://doi.org/10.1007/s00228-010-0932-0
  » https://doi.org/10.1007/s00228-010-0932-0
• ²¹ Schubert I , Ihle P , Sabatowski R . Increase in opiate prescription in Germany between 2000 and 2010: a study based on insurance data . Dtsch Arztebl Int . 2013 Jan ; 110 ( 4 ): 45 - 51 . https://doi.org/10.3238/arztebl.2013.0045
  » https://doi.org/10.3238/arztebl.2013.0045
• ²² Fischer B , Jones W , Urbanoski K , Skinner R , Rehm J . Correlations between prescription opioid analgesic dispensing levels and related mortality and morbidity in Ontario, Canada, 2005-2011 . Drug Alcohol Rev . 2014 Jan ; 33 ( 1 ): 19 - 26 . https://doi.org/10.1111/dar.12089
  » https://doi.org/10.1111/dar.12089
• ²³ Garcia del Pozo J , Carvajal A , Viloria JM , Velasco A , Garcia del Pozo V . Trends in the consumption of opioid analgesics in Spain. Higher increases as fentanyl replaces morphine . Eur J Clin Pharmacol . 2008 Apr ; 64 ( 4 ): 411 - 5 . https://doi.org/10.1007/s00228-007-0419-9
  » https://doi.org/10.1007/s00228-007-0419-9
• ²⁴ Lam KK , Kunder S , Wong J , Doufas AG , Chung F . Obstructive sleep apnea, pain, and opioids: is the riddle solved? Curr Opin Anaesthesiol . 2016 Feb ; 29 ( 1 ): 134 - 40 . https://doi.org/10.1097/ACO.0000000000000265
  » https://doi.org/10.1097/ACO.0000000000000265
• ²⁵ Overholser BR , Foster DR . Opioid pharmacokinetic drug-drug interactions . Am J Manag Care . 2011 Sep ; 17 Suppl 11 : S276 - 87 .
• ²⁶ Dassanayake T , Michie P , Carter G , Jones A . Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence . Drug Saf . 2011 Feb ; 34 ( 2 ): 125 - 56 . https://doi.org/10.2165/11539050-000000000-00000
  » https://doi.org/10.2165/11539050-000000000-00000
• ²⁷ Lima MG , Álvares J , Guerra AA , Costa EA , Guibu IA , Soeiro OM , et al . Indicators related to the rational use of medicines and its associated factors . Rev Saude Publica . 2017 Nov ; 51 suppl 2 : 23s . https://doi.org/10.11606/S1518-8787.2017051007137
  » https://doi.org/10.11606/S1518-8787.2017051007137
• ²⁸ Stopa SR , Malta DC , Monteiro CN , Szwarcwald CL , Goldbaum M , Cesar CL . Use of and access to health services in Brazil, 2013 National Health Survey . Rev Saude Publica . 2017 Jun ; 51 suppl 1 : 3s . https://doi.org/10.1590/s1518-8787.2017051000074
  » https://doi.org/10.1590/s1518-8787.2017051000074
• ²⁹ Reis CM , Mambrini JV , da Matta-Machado AT , Amaral JH , Werneck MA , Abreu MH . Primary dental care evaluation in Brazil: an item response theory approach . J Public Health Dent . 2017 Sep ; 77 ( 4 ): 317 - 24 . https://doi.org/10.1111/jphd.12210
  » https://doi.org/10.1111/jphd.12210
• ³⁰ Hart JT . The inverse care law . Lancet . 1971 Feb ; 1 ( 7696 ): 405 - 12 . https://doi.org/10.1016/S0140-6736(71)92410-X
  » https://doi.org/10.1016/S0140-6736(71)92410-X
• ³¹ Dehmoobadsharifabadi A , Singhal S , Quiñonez C . Investigating the “inverse care law” in dental care: A comparative analysis of Canadian jurisdictions . Can J Public Health . 2017 Mar ; 107 ( 6 ): e538 - 44 . https://doi.org/10.17269/CJPH.107.5454
  » https://doi.org/10.17269/CJPH.107.5454
• ³² Cascaes AM , Camargo MB , Castilhos ED , Silva LE , Barros AJ . Private dental insurance expenditure in Brazil . Rev Saude Publica . 2018 ; 52 : 24 . https://doi.org/10.11606/S1518-8787.2018052000340
  » https://doi.org/10.11606/S1518-8787.2018052000340
• ³³ Macarevich A , Pilotto LM , Hilgert JB , Celeste RK . User satisfaction with public and private dental services for different age groups in Brazil . Cad Saude Publica . 2018 Feb ; 34 ( 2 ): e00110716 . https://doi.org/10.1590/0102-311x00110716
  » https://doi.org/10.1590/0102-311x00110716
• ³⁴ Almeida AP , Nunes BP , Duro SM , Facchini LA . Socioeconomic determinants of access to health services among older adults: a systematic review . Rev Saude Publica . 2017 May ; 51 ( 0 ): 50 . https://doi.org/10.1590/s1518-8787.2017051006661
  » https://doi.org/10.1590/s1518-8787.2017051006661
• ³⁵ Koh HK , Piotrowski JJ , Kumanyika S , Fielding JE . Healthy people: a 2020 vision for the social determinants approach . Health Educ Behav . 2011 Dec ; 38 ( 6 ): 551 - 7 . https://doi.org/10.1177/1090198111428646
  » https://doi.org/10.1177/1090198111428646
• ³⁶ Watt RG . Social determinants of oral health inequalities: implications for action . Community Dent Oral Epidemiol . 2012 Oct ; 40 Suppl 2 : 44 - 8 . https://doi.org/10.1111/j.1600-0528.2012.00719.x
  » https://doi.org/10.1111/j.1600-0528.2012.00719.x
• ³⁷ Ministério da Saúde (BR) . Secretaria de Atenção à Saude . Secretaria de SB Brasil 2010: Pesquisa Nacional de Saúde Bucal: resultados principais . Brasília, DF : Ministério da Saúde ; 2012 .
• ³⁸ Jones CM , Paulozzi LJ , Mack KA . Sources of prescription opioid pain relievers by frequency of past-year nonmedical use United States, 2008-2011 . JAMA Intern Med . 2014 May ; 174 ( 5 ): 802 - 3 . https://doi.org/10.1001/jamainternmed.2013.12809
  » https://doi.org/10.1001/jamainternmed.2013.12809
• ³⁹ Krawczyk N , Greene MC , Zorzanelli R , Bastos FI . Rising trends of prescription opioid sales in contemporary Brazil, 2009-2015 . Am J Public Health . 2018 May ; 108 ( 5 ): 666 - 8 . https://doi.org/10.2105/AJPH.2018.304341
  » https://doi.org/10.2105/AJPH.2018.304341

Publication Dates

• Publication in this collection
  15 Aug 2019
• Date of issue
  2019

History

• Received
  21 Feb 2019
• Accepted
  11 June 2019
• Reviewed
  24 June 2019