A 70-year-old woman presented with a conjunctival cyst after a towel hit her left eye (LE) 2 weeks prior. She was initially prescribed with retinyl acetate, aminoacids, methionine, and chloramphenicol ointment as well as a lubricant eyedrop for 7 days; these did not provide resolution. Ophthalmological examination revealed a translucent conjunctival inclusion cyst surrounded by several small vessels in the LE temporal side (Figure 1A). Following administration with 0.5% timolol maleate eyedrops twice daily, the inclusion cyst completely resolved 2 weeks later. Figure 1B shows the conjunctiva of the LE 50 days after the patient’s initial presentation.
Although rare, acquired conjunctival cysts(11 Thatte S, Jain J, Kinger M, Palod S, Wadhva J, Vishnoi A. Clinical study of histologically proven conjunctival cysts. Saudi J Ophthalmol. 2015;29(2):109-15.) may develop due to local trauma. Surgical excision is usually indicated(22 Song JJ, Finger PT, Kurli M, Wisnicki HJ, Iacob CE. Giant secondary conjunctival inclusion cysts: a late complication of strabismus surgery. Ophthalmology. 2006;113(6):1049.e1-2.). Before excision, timolol maleate was initially prescribed, hypothesizing that the vessels surrounding the cyst might possess beta-adrenergic receptors similar to pyogenic granulomas and capillary hemangiomas(33 Oke I, Alkharashi M, Petersen RA, Ashenberg A, Shah AS. Treatment of ocular pyogenic granuloma with topical timolol. JAMA Ophthalmol. 2017;135(4):383-5.,44 Jaiswal H, Patidar N, Shah C, Singh R, Jain E, Piyush P. Topical timolol 0.5% as the primary treatment of ophthalmic pyogenic granuloma: A prospective, single-arm study. Indian J Ophthalmol [Internet]. 2021 ][cited 2023 Jan 24];69(5):1155-60.Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186631/
https://www.ncbi.nlm.nih.gov/pmc/article...
), which are effectively treated with beta-blockers.
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Funding: This study received no specific financial support.
REFERENCES
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1Thatte S, Jain J, Kinger M, Palod S, Wadhva J, Vishnoi A. Clinical study of histologically proven conjunctival cysts. Saudi J Ophthalmol. 2015;29(2):109-15.
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2Song JJ, Finger PT, Kurli M, Wisnicki HJ, Iacob CE. Giant secondary conjunctival inclusion cysts: a late complication of strabismus surgery. Ophthalmology. 2006;113(6):1049.e1-2.
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3Oke I, Alkharashi M, Petersen RA, Ashenberg A, Shah AS. Treatment of ocular pyogenic granuloma with topical timolol. JAMA Ophthalmol. 2017;135(4):383-5.
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4Jaiswal H, Patidar N, Shah C, Singh R, Jain E, Piyush P. Topical timolol 0.5% as the primary treatment of ophthalmic pyogenic granuloma: A prospective, single-arm study. Indian J Ophthalmol [Internet]. 2021 ][cited 2023 Jan 24];69(5):1155-60.Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186631/
» https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186631/
Publication Dates
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Publication in this collection
27 May 2024 -
Date of issue
2024
History
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Received
13 Nov 2023 -
Accepted
02 Feb 2024