IMAGES IN NEUROLOGY
Hyperintense basal ganglia on MR imaging in hematopoietic stem cell transplantation recipient
Hiperintensidade nos gânglios da base em ressonância magnética do crânio em paciente pós-transplante de células tronco hematopoiética
Plínio M.G. de LimaI; Flávia Z. PiazeraII; Marco A. BitencourtII; Elenaide C. NunesII; Juliane MorandoII; Sérgio C. FortierII; Adriana KoliskiII; Ricardo PasquiniII; Jorge ZavalaI; Hélio A.G. TeiveI
INeurology of Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil
IIBone Marrow Transplantation Services of Internal Medicine Department, Hospital de Clínicas, Federal University of Paraná, Curitiba PR, Brazil
Correspondence Correspondence: Hélio A.G. Teive Rua General Carneiro 1103/102 80060-150 Curitiba PR - Brasil E-mail: hagteive@mps.com.br
A 13-year-old boy presented seizures on day +37 after allogenic hematopoietic stem cell transplantation (HSCT) for Fanconi anemia. After HSCT this patient had received total parental nutrition (TPN) for 21 days. Neurological examination was normal. A MRI of the brain (Figure A-B) showed symmetric areas of hyperintensity in the basal ganglia. Serum manganese (Mn) was 7.7 µg/L (reference value <3.3 µg/L).
Basal ganglia Mn deposition, associated to elevated blood Mn levels, has been described in children receiving long-term TPN1-3.
Received 12 March 2011
Accepted 31 March 2011
- 1. Fell JM, Reynolds AP, Meadows N, et al. Manganese toxicity in children receiving long-term parenteral nutrition. Lancet 1996;347:1218-1221.
- 2. Quaghebeur G, Taylor WJ, Kingsley DPE. MRI in children receiving total parenteral nutrition. Neuroradiology 1996;38:680-683.
- 3. Kim Y. Neuroimaging in manganism. Neurotoxicology 2006;27:369-372.
Publication Dates
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Publication in this collection
01 Sept 2011 -
Date of issue
Aug 2011