A 75-year-old man with IgM-kappa restricted Waldenström macroglobulinemia (WM) was admitted due to paraparesis and sensory deficits of the lower extremities. Cerebrospinal fluid analysis revealed 140 cells/mm3, increased protein (295mg%), albumin quotient (16.57) and the presence of IgM-kappa chains in immunofixation electrophoresis. Cytology showed lymphoplasmacytoid cells. Magnetic resonance imaging (MRI) demonstrated spinal cord hydromelia and gadolinium-enhancing root lesions (Figure). These findings suggested central nervous system (CNS) involvement of WM or type A Bing-Neel syndrome11. Fintelmann F, Forghani R, Schaefer PW, Hochberg EP, Hochberg FH. Bing-Neel Syndrome revisited. Clin Lymphoma Myeloma. 2009;9(1):104-6. https://doi.org/10.3816/CLM.2009.n.028
https://doi.org/10.3816/CLM.2009.n.028...
. In Bing-Neel syndrome, MRI usually discloses tumoral or diffuse CNS abnormalities with gadolinium-enhancing leptomeningeal, parenchymal or cranial nerve lesions22. Malkani RG, Tallman M, Gottardi-Littell N, Karpus W, Marszalek L, Variakojis D et al. Bing-Neel syndrome: an illustrative case and a comprehensive review of the published literature. J Neurooncol. 2010;96(3):301-12. https://doi.org/10.1007/s11060-009-9968-3
https://doi.org/10.1007/s11060-009-9968-...
. Chemotherapy (intrathecal methotrexate, rituximab, cyclophosphamide and vincristine) was dispensed with marked clinical improvement.
References
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1Fintelmann F, Forghani R, Schaefer PW, Hochberg EP, Hochberg FH. Bing-Neel Syndrome revisited. Clin Lymphoma Myeloma. 2009;9(1):104-6. https://doi.org/10.3816/CLM.2009.n.028
» https://doi.org/10.3816/CLM.2009.n.028 -
2Malkani RG, Tallman M, Gottardi-Littell N, Karpus W, Marszalek L, Variakojis D et al. Bing-Neel syndrome: an illustrative case and a comprehensive review of the published literature. J Neurooncol. 2010;96(3):301-12. https://doi.org/10.1007/s11060-009-9968-3
» https://doi.org/10.1007/s11060-009-9968-3
Erratum
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Bing-Neel syndrome.Arq Neuropsiquiatr 2017;75(4):262. https://doi.org/10.1590/0004-282X20170017The name of the authors:Artemiadis K Artemios1,2, Terentiou Aspasia2, Kolokythopoulos Dimosthenis3, Triantafyllou Nikos1, Nikolaou George2Should be:Artemios K. Artemiadis1,2, Aspasia Terentiou2, Dimosthenis Kolokythopoulos3, Nikos Triantafyllou1, George Nikolaou2Epidemiological and clinical factors impact on the benefit of riluzole in the survival rates of patients with ALS
Publication Dates
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Publication in this collection
Apr 2017
History
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Received
18 Aug 2016 -
Accepted
21 Nov 2016