Abstract
The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
acridanone-hydrazones; Schistosoma mansoni; experimental shchistosomiasis
Activity of 9-acridanone-hydrazone drugs detected at the pre-postural phase, in the experimental schistosomiasis mansoni
Leogenes Horacio Pereira1
Paulo Marcos Zech Coelho1
Jose Oswaldo Costa2
Rômulo Teixeira de Mello3
Universidade Federal de Minas Gerais, ICB, Departamento de Parasitologia, Belo Horizonte, Brasil
Universidade Federal de Minas Gerais, Escola de Veterinária, Departamento de Medicina Veterinária Preventiva, Belo Horizonte, Brasil
Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departemento de Análises Clínicas e Toxicológicas, Belo Horizonte, Brasil
The compound Ro-15.5458/000, derivative in the class of 9-acridanone-hydrazones, was found to be effective against Schistosoma mansoni in mice, killing almost all the skin schistosomules (24 hr after infection), when administered at the dose of 100 mg/kg. In experiments carried out with Cebus monkeys, the drug was shown to be fully effective at 25 mg/kg, 7 days after infection. These data, associated with the good results obtained earlier at the post-postural phase of schistosomiasis, allow the inference that this promising compound may be important in the set of antischistosomal drugs, depending on further toxicological and clinical tests.
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Publication Dates
-
Publication in this collection
01 June 2009 -
Date of issue
June 1995
