Treatment adherence and frailty syndrome in hypertensive older adults

Adherencia al tratamiento y síndrome de fragilidad en adultos mayores hipertensos

Abstract

Objective:

To analyze the association between adherence to antihypertensive treatment and frailty syndrome in hypertensive older adults.

Method:

A descriptive, cross-sectional study with a quantitative approach with older adults. The data collection took place between November 2017 and March 2018, evaluating sociodemographic information, adherence to antihypertensive treatment, lifestyle and frailty through the Edmonton Frail Scale. The Kruskal-Wallis test and the Chi-squared test were used for data analysis, considering a 95% confidence interval and a significance level of p<0.05.

Results:

There were 193 older adults who participated in the study. The average age was 80.94 (sd ± 7.17) years, with a predominance of females (72%) and widows (43.5%). The factors which were associated with adherence to treatment were diastolic blood pressure, education and the time that the older adult had smoked (p<0.05). Frailty was not associated with treatment adherence levels (p=0.095).

Conclusion:

There was no association between frailty scores and control of arterial hypertension; however, adequate monitoring and nursing care are essential in assessing adherence to treatment in order to reduce the aggravations of the disease and frailty syndrome development.

Descriptors:
Aged; Hypertension; Medication Adherence; Frailty; Geriatric Nursing

Resumen

Objetivo:

Analizar la asociación entre la adherencia al tratamiento antihipertensivo y el síndrome de la fragilidad en el adulto mayor con hipertensión.

Método:

Estudio descriptivo, transversal de abordaje cuantitativa con adultos mayores. La recolección de los datos ocurrió entre noviembre de 2017 y marzo de 2018, evaluando las informaciones sociodemográficas, la adherencia al tratamiento antihipertensivo, los hábitos de vida y la fragilidad, por medio de Edmonton Frail Scale. Para el análisis de los datos fuer​on utilizados el teste de Kruskal-Wallis y el teste de qui-quadrado. Para los dos testes el intervalo de confianza fue de​l 95% y el nivel de significancia p<0,05.

Resultados:

Participaron en el estudio 193 adultos mayores. La media de edad fue de 80,94 (dp ± 7,17) años, con predominio del sexo femenino (72%) y de viudas (43,5%). Los factores que presentaron asociación con la adherencia al tratamientofueran la presión arterial diastólica, la escolaridad y el tiempo que el adulto mayor fuma (p<0,05). La fragilidad no presentó asociación con los niveles de adherencia al tratamiento(p=0,095).

Conclusión:

No se ha constatado asociación entre los escores de fragilidad y el control de la hipertensión arterial; asímismo, es fundamental en la evaluación de la adherencia al tratamiento, del acompañamiento conveniente y la asistencia de enfermería para reducir la gravedad de la enfermedad y el desarrollo del síndrome de fragilidad.

Descriptores:
Anciano; Hipertensión; Cumplimiento de la Medicación; Fragilidad; Enfermería Geriátrica

Resumo

Objetivo:

Analisar a associação entre a adesão ao tratamento anti-hipertensivo e a síndrome da fragilidade no idoso hipertenso.

Método:

Estudo descritivo, transversal de abordagem quantitativa com idosos. A coleta de dados ocorreu entre novembro de 2017 e março de 2018, avaliando as informações sociodemográficos, a adesão ao tratamento anti-hipertensivo, os hábitos de vida e a fragilidade, por meio da Edmonton Frail Scale. Para a análise dos dados utilizou-se o teste de Kruskal Wallis e o teste de qui-quadrado, considerando o intervalo de confiança de 95% e o nível de significância p<0,05.

Resultados:

Participaram do estudo 193 idosos. A média de idade foi de 80,94 (dp ± 7,17) anos, com predomínio do sexo feminino (72%) e de viúvas (43,5%). Os fatores que apresentaram associação com a adesão ao tratamento foram a pressão arterial diastólica, a escolaridade e o tempo que o idoso fuma (p<0,05). A fragilidade não apresentou associação com os níveis de adesão ao tratamento (p=0,095).

Conclusão:

Não se constatou associação entre os escores de fragilidade e o controle da hipertensão arterial; entretanto, é fundamental na avaliação da adesão ao tratamento, o acompanhamento adequado e a assistência de enfermagem para reduzir os agravos da doença e o desenvolvimento da síndrome de fragilidade.

Descritores:
Idoso; Hipertensão; Adesão à Medicação; Fragilidade; Enfermagem Geriátrica

INTRODUCTION

The increase in the older adult population in the world and in Brazil directly affects the public health system, as pathological conditions can compromise the vascular system over the course of the aging process, thereby making this population more susceptible to morbidities such as systemic arterial hypertension (SAH)(¹).

This disease is currently estimated as one of the main global public health problems, as it has a high prevalence and low control rates, resulting in significant numbers of cardiovascular morbidity and mortality(²). It is estimated that 25% of the adult population in Brazil is diagnosed with SAH, and it is estimated that its prevalence will be 40% in 2025(³). A Brazilian population-based study estimates that the prevalence among older adults is 75.6% (95%CI = 71.1-77.9)(⁴).

The association between aging and the hypertension prevalence is direct and linear, as it is related to the increase in life expectancy of the population(⁵). In a meta-analysis study carried out with older adults from urban areas in Brazil, the researchers estimated arterial hypertension prevalence of 68%(⁶). In addition to age, race, gender, genetic predisposition, stress, overweight, obesity, and lifestyle habits considered unhealthy such as physical inactivity and excessive alcohol consumption, smoking and excessive salt consumption are also considered as risk factors or predictors of the disease(⁵).

Non-adherence or inadequate adherence to drug treatments are the main causes of ineffective therapy in Brazil and worldwide(¹). The best control of hypertension aims to decrease the incidence of disease and prevent a substantial number of deaths. In this sense, Nursing has a fundamental role in care practice with the use of nursing diagnosis, constituting a tool which directs actions and the care plan with educational actions as the main intervention strategy to increase adherence to antihypertensive treatment(⁷).

Adherence to antihypertensive treatment in older adults considerably reduces the risk of stroke, controls heart failure and reduces mortality from cardiovascular diseases(⁸). According to the World Health Organization, both the diagnosis and treatment of arterial hypertension have been challenging in older adults, as they are patients who need careful pharmacotherapy; ideally, monotherapy with low doses of antihypertensive medication(⁹).

Adherence and medication intake on a regular basis are paramount for effective therapy in older adults; therefore, it is necessary for the older adults to get involved in their treatment, understand the objectives of the adopted therapy and feel good during the care process(¹⁰). Some obstacles found in order for drug treatment to be effective are “forgotten” doses, economic situation, side effects of drugs, the presence of comorbidities, advanced age and being considered frail(¹¹).

According to the consensus proposed by a group of researchers, a frail older adult is one who presents a decrease in strength and resistance, as well as a decline in physiological functions, making them vulnerable and consequently having increased dependence and/or death(¹²). In this sense, frailty can be understood as a multidimensional syndrome of complex etiology, requiring an assessment using instruments which have a holistic view of older adults, being determined or modified by biological, psychological and social factors which generate a condition of a multifactorial nature, uncomfortable and dynamic according to the individual’s history or life course(¹³-¹⁵).

The following criteria should be considered for a frail older adult: five or more diseases, using at least five medications, presenting impaired physical mobility, having a history of falls and recurrent hospitalizations, precarious family relationships, cognitive impairment and functional dependence(¹⁶).

The frailty syndrome in older adults has been widely discussed in recent years, since it affects 15% to 20% of these people aged over 60, and 30% of those over 80 years old(¹⁷). Moreover, the presence of the syndrome has been considered as a causative and prognostic factor of cardiovascular diseases, with the estimated prevalence being between 25 to 50% of older adults with heart problems being frail and 21% having low level adherence, while only 12.3% of older adults in the non-frail group have low level adherence(¹⁸).

Assessing the association of frailty and adherence to antihypertensive treatment can be the first step to understand whether there is an interaction between them, and it can ultimately optimize the treatment of existing hypertension and establish therapeutic goals in people who are frail. However, studies in Brazil which demonstrate the relationship between frail older adults, hypertensive disease and adherence to pharmacological treatment in a way which would enable thinking about risk factors and encouraging means for interventions in the frailty syndrome are still scarce.

In view of the problem presented above, this investigation is justified due to the high prevalence of SAH in older adults and the possible relationship between adherence and the presence of frailty which requires attention from professionals working in health services. To this end, the aim of the study was to analyze the association between adherence to antihypertensive treatment and the frailty syndrome in hypertensive older adults.

METHOD

Study design

This is a descriptive, cross-sectional study with a quantitative approach.

Population

The study population consisted of older adults aged 65 or over living in the urban area of the city of Ribeirão Preto, SP, Brazil.

The sample was defined in the first phase of this investigation in 2007, which was a funded project. However, this study composes the third stage of this research in which the older adults interviewed in 2017/2018 were evaluated, thereby totaling 262 of the initial sample.

The research sampling process was followed in all stages, being probabilistic by a two-stage conglomerate, in which 30 census sectors were initially drawn from the 600 sectors existing in the municipality. A fixed number of households were subsequently visited in the second stage, which guaranteed self-weighting in the sample. There were 515 older adults selected as a way to prevent refusals, which resulted in the expected rate of 80%.

As this is a follow-up study with losses and deaths, the maintained sample was 262 older adults, among whom 193 (73.3%) met the established inclusion criterion, which was to have a medical diagnosis of systemic arterial hypertension.

Data collection

Data collection was carried out between the months of December 2017 and March 2018 at the participants’ homes through a structured interview conducted by undergraduate and graduate students previously trained by the project coordinator, and using a questionnaire with validated instruments. The interviews lasted an average of 50 minutes.

The Morisky Medication Adherence Scale (MMAS), validated in Brazil(¹⁹), was used to evaluate adherence to hypertensive drug treatment, which consisted of the following questions: 1) Do you sometimes have problems remembering to take your medication? 2) Do you sometimes neglect to take your medication? 3) When you are feeling better, do you sometimes stop taking your medication? 4) If you feel worse when taking the medication, do you sometimes stop taking it? Good adherence was considered when all responses were negative and low adherence when two or more responses were affirmative on the MMAS instrument.

Adherence was also assessed based on manual pill counting to verify the degree of coincidence between the amount of pills used by the older adult in a given time interval and the amount which should have been used in that same time interval (according to the prescribed therapeutic regimen). Thus, manual counting of the pills which were on the chart of each medication was performed and compared with the prescribed therapeutic regimen(²⁰).

The calculation used was:

Degree of agreement between used and prescribed pills = (NPA - NPR) x100/NCP, in which:

NPA = number of pills acquired by the patient in the last visit.

NPR = number of pills remaining in the package.

NCP = number of pills which should have been consumed according to the prescription in the interval between acquisition and counting the pills.

It is reported that the calculation was made separately for each older adult who used more than one medication.

The MMSA score was taken into account for creating the adhesion variable: Adherent - no positive response; Moderate adherence - 1 to 2 positive responses; and Low adherence - 3 to 4 positive responses. Thus, the following was obtained from the discrepancy and from this score: Optimal adhesion - no discrepancy and adherent on the Morisky; Good adherence - no discrepancy and moderate adherence or discrepancy and adherent on the Morisky; Regular adherence - presenting a discrepancy and moderate adherence on the Morisky or no discrepancy and low adherence; and Poor adherence - presenting a discrepancy and low adherence on the Morisky. A weighted adherence (average of the scores) was created based on the adherence of each medication, ranging from 0 to 100% for each participant, which resulted in the following values: above 75%, good; 74 to 50%, regular; below 50%, bad(²⁰).

The frailty assessment was performed by the Edmonton Frail Scale(¹⁵), validated for the Portuguese language(²¹). This scale has nine domains: cognition, general health status, functional independence, social support, medication use, nutrition, mood, continence and functional performance(¹⁵,²¹). The scale score(¹⁵,²¹) varies from 0 to 17 points, with the maximum value indicating a higher level of frailty.

The independent variables used for the purposes of analysis were: gender (male, female), self-reported age (years), marital status (single, married, widowed, divorced), years of education, total self-reported diseases, income (in Brazilian currency Reais), alcohol use (amount ingested per week or month) and tobacco use (yes or no), and for how long they have used/consumed it.

Blood pressure was measured three times according to the recommendations of the VII Brazilian Guideline for Arterial Hypertension using a calibrated aneroid sphygmomanometer (Techline BP-1305 Digital Arm Pressure Meter), with the individual sitting and at rest for at least fifteen minutes. Three systolic (SBP) and diastolic (DBP) blood pressure measurements were verified, with an interval of one to two minutes, thus obtaining the means for each of these variables(⁵).

Data analysis and processing

An electronic spreadsheet was created in the Microsoft Excel^® program to elaborate the database, in which double entry typing was performed. The data were imported into a statistical program to perform the descriptive analysis. Quantitative variables were analyzed using central tendency (mean and median) and dispersion (sd = standard deviation) measures and categorical variables in absolute and relative frequency. The Kruskal-Wallis test was used to analyze adherence with three groups and independent variables, and the Chi-squared test was used to compare adherence and variables related to the older adults’ lifestyles, such as the use of tobacco (tobacco), the performance of some type of physical activity and the intake of alcoholic beverages. A 95% confidence interval and significance level of p<0.05 were considered for both tests.

Ethical aspects

The research project was approved by the Research Ethics Committee of the Ribeirão Preto School of Nursing at the Universidade de São Paulo under Protocol No. 089/2017, following the recommendations in Resolution 466/2012 of the National Health Council. The older adults signed an Informed Consent Form in two copies.

RESULTS

There were 193 older adults who participated in the study. The results showed that the older adults in the study had an average age of 80.94 (± 7.17) years, with a minimum of 65 and a maximum of 97 years. The majority were female (72%), widows (43.5%), who use health insurance (49.2%) and also the Unified Health System (SUS - Sistema Único de Saúde) (48.2). The average years of education of these older adults was 5.28 years (SD ± 4.87 years). The monthly income in minimum monthly salaries ranged from one (18.1%) to more than 10 (4.7%), with the highest concentration between three and five salaries (33.2%). The number of self-reported diseases was an average of 6.03 (SD = 3.84). Only 9.3% of the older adults used self-medication, and the majority (57.5%) showed good adherence to antihypertensive treatment (Table 1).

Table 1
Characterization of hypertensive older adults who use antihypertensive drugs - Ribeirão Preto, SP, Brazil, 2017-2018.

Sociodemographic variables	n	%	Mean (sd)	Min	Max
Age (years)			80.94 (7.17)	65	97
Education (years of study)			5.28 (4.87)	0	22
Total self-reported diseases			6.03 (3.84)	1	18
Gender
Male	54	28.0
Female	139	72.0
Civil status
Single	16	8.3
Married	77	39.9
Divorced/Separated	14	7.3
Widowed	84	43.5
Other	2	1.0
Monthly income of the older adult (in minimum monthly salaries)
Up to one	35	18.1
02	51	26.4
03 to 05	64	33.2
06 to 09	30	15.5
More than 10	9	4.7
Did not know or did not respond	4	2.1
Health services
SUS	93	48.2
Health Insurance	95	49.2
Private	2	1.0
Other	3	1.6
Self-medication
Yes	18	9.3
No	175	90.7
Adhesion
Good	111	57.5
Regular	65	33.7
Bad	17	8.8

When the association between lifestyle habits was verified, such as the use of tobacco (tobacco), the performance of some type of activity and the consumption of alcoholic beverages, with the adherence to antihypertensive treatment by the older adult, there was no statistically significant association (Table 2).

Table 2
Association between gender and life habits and adherence to antihypertensive treatment of hypertensive older adults - Ribeirão Preto, SP, Brazil, 2017-2018.

Variables	Adhesion						p*
	Good		Regular		Bad
	n	%	n	%	n	%
Gender							0.573
Male	29	53.7	20	37.0	5	9.3
Female	82	59.0	45	32.4	12	8.6
Smoking (Tobacco)							0.579
Yes	6	46.2	5	38.5	2	15.4
No	105	58.3	60	33.3	15	8.3
Perform some type of physical activity							0.830
No	89	58.2	50	32.7	14	9.2
Yes	22	55.0	15	37.5	3	7.5
Alcohol consumption							0.123
Never	90	59.6	51	33.8	10	6.6
Once a month	12	48.0	9	36.0	4	16.0
Two to four times a month	5	55.6	3	33.3	1	11.1
Two to three times a week	2	50.0	2	50.0	0	0
Four or more times a week	2	50.0	0	0	2	50.0

• *Chi-squared test.

It was observed that there was a statistically significant association between the mean diastolic blood pressure and adherence to antihypertensive medication, with the DBP being lower in older adults with good adherence (p<0.05, 70.95 vs 80.65). In the relationship between years of education and adherence to drug treatment, the older adults who showed good adherence had a higher average of years in which they had attended school (p<0.05, 5.85 vs 2.94). Moreover, the time that the individual smoked also showed a statistically significant relationship with adherence, as older adults who smoked for less time had good adherence to treatment (p<0.05, 17.05 vs 18.86) (Table 3).

No statistical significance was identified when analyzing the frailty scores and their relationship with the results of the older adults’ adherence to antihypertensive treatment, demonstrating that there was no association between frailty and adherence of the hypertensive older adult to antihypertensive treatment, according to the Table 3.

Table 3
Association between factors which interfere with adherence and adherence to antihypertensive treatment - Ribeirão Preto, SP, Brazil, 2017-2018.

Variables	Adhesion			p *
	Good (sd)	Regular (sd)	Bad (sd)
Systolic Blood Pressure	142.52 (22.67)	140.38 (22.30)	155.78 (30.56)	0.271
Diastolic Blood Pressure	70.95 (11.34)	73.39 (11.13)	80.64 (14.27)	0.032
Education	5.85 (5.08)	4.92 (4.60)	2.94 (3.75)	0.011
Self-reported diseases (Total)	5.64 (3.26)	6.34 (3.41)	7.35 (4.77)	0.255
Smoking time (Years)	17.05 (20.74)	32.19 (20.10)	18.86 (5.55)	0.035
Frailty score	5.50 (3.12)	6.12 (2.35)	6.82 (2.878)	0.095

• * Kruskal-Wallis test.

DISCUSSION

There was a good adherence to antihypertensive treatment in the study population, and the associated factors were education and the duration of tobacco use. However, there was no association between the frailty score and adherence to this treatment.

The prevalence of adherence to drug treatment in the present study was 57.5%, being higher than that found in Taiwanese older adults at a medical center undergoing dialysis treatment(²²), and in Cameroonian adults and older adults(²³). However, it was lower than the data from an investigation carried out in Vitória, Espírito Santo state, Brazil, which was 73.3%(²⁴).

Another study showed that the percentage of people over 55 years old in New York who adhered to antihypertensive treatment according to the Morisky scale was only 18.8%, being well below that found in this investigation(¹¹). The difficulty in comparing the data is that studies involving hypertensive patients, whether in Brazil or in other countries, involve participants over the age of 55. The World Health Organization recommends 80% adherence to antihypertensive treatment(⁹). Thus, it is evident from all studies that there is still a need to work on adherence in older adult patients to avoid worsening the clinical condition and problems, such as decompensation of arterial hypertension or of other controlled conditions.

The results among the older adults showed that there was no significant difference between men and women regarding adherence to antihypertensive treatment. Worldwide indices indicate that the difference in the prevalence of arterial hypertension between the genders is small(⁹); however, women seem to have more satisfactory adherence when compared to men in drug treatments(²⁵).

Good adherence depends on how the older adults view the treatment. Something that was consensus in this study and in the international data was the use of methods which depend on involving the older adult during treatment, on their understanding of how the process will occur and on their general well-being. Authors in Italy found that failure to adhere to treatment is due to missed doses because of adverse treatment effects, financial considerations, advancing age, the presence of concomitant illnesses and the onset of frailty syndrome(¹⁰).

Non-adherence to drug treatment in Brazil is related to unemployment, low income, tobacco use, decreased or lack of physical activity, and health conditions through the increase in the number of chronic diseases and medical appointments in last 12 months(²⁶).

In this study, it was found that education was associated with adherence to treatment, corroborating with research data from Poland(¹¹) in which the influence of the frailty syndrome on medication adherence in older adults with hypertension showed that high education is a predictor for good adherence. The same study points out that the presence of diseases negatively affected adherence, as well as the fact of living alone, the lack of social support, the death of a partner, divorce and the traumatic event.

A population-based study in Brazil showed an association between adherence and education(²⁶), corroborating the findings of the present study. For Ethiopian researchers(²⁷), education is related to the understanding that the older adults have about their diagnosis and the importance of treating the disease, as prescribed by the physician.

A decrease in consumption was identified regarding the time the participant smoked cigarettes, improving adherence to hypertensive treatment, differing from the findings of Vitória-ES(²⁴), which showed that both the use of tobacco and alcoholic beverage consumption did not interfere in adherence. It is important to note that smoking is among the risk factors listed by the VII Brazilian Guideline for Hypertension in the control and prevention of arterial hypertension(⁵).

Likewise, it was found that the diastolic blood pressure measurement was associated with adherence to treatment. Research on the self-reported hypertension of the Brazilian population showed that drug monotherapy is not enough to decrease blood pressure levels in 2/3 of the cases; in addition, the older adults need combination therapy for adequate control of systolic BP(²⁸). Such results corroborate the data of the present study, since the older adults with good adherence have lower diastolic BP values and maintenance of systolic BP values.

An integrative review on adherence to pharmacological treatment in hypertensive older adults pointed out that the values of systolic blood pressure are below 140mmHg and 90mmHg for diastolic blood pressure when they adhere to treatment(²⁹). These findings differ from those found in the study herein, but can be explained due to existing research in Brazil and in other countries which have assessed the adherence of older adult hypertensive patients through different methods and populations, making it difficult to compare the findings.

Research carried out in Ceará state with Primary Care users who are monitored by the Hiperdia program shows that even with the SAH diagnosis and treatment, only 25% of users maintain pressure levels in a desirable way. Further, the proportion of users with BP < 140x90 mmHg after starting treatment varied between 6% and 25%, making the low adherence to treatment from the lack of pressure control evident(³⁰). The older adults in the present study with better blood pressure, especially diastolic, had good adherence to treatment.

According to the VII Brazilian Guideline for Hypertension, it is indicated that the recommended BP for hypertensive older adults under the age of 80 is < 145/85 mmHg. Ideally, the older adult should adhere to treatment to avoid an increase in cardiovascular risk and non-pharmacological treatment should be implemented in association with pharmacological treatment in all hypertension stages and when the patient has a BP of 135-139/85-89 mmHg⁽⁵⁾.

Regarding the frailty syndrome, there was no association with adherence to treatment, but clinically the lack of adherence to prescription drugs reduces the benefits of therapy and can decrease therapeutic efficacy(¹¹). International authors reinforce this importance by stating that non-adherence corresponds to 30% to 50% of failures in the treatment of older adults(²⁶).

In a study in Taiwan(²²), the best adherence to treatment was related to frail patients with advanced age, as they are more attentive to their health and more compliant with the prescribed treatments. According to researchers from Ethiopia(²⁷), developed and developing countries have better healthcare and differentiated access to health facilities, constituting elements which positively affect adherence in comparison with this study and those carried out in countries with difficult access to health services.

Using the Tilburg scale to identify frailty, researchers found that non-frail older adults had a lower mean (4.1 ± 2.0) associated with adherence to pharmacological treatment of hypertension, while frail people obtained a higher mean (6.1 ± 2.1)(¹⁷). The Edmonton Frail Scale was used in this study, and the older adults with a good adherence had a lower mean (5.50 ± 3.12) compared to those who had an adherence considered to be bad (6.82 ± 2.878).

The literature presents conflicting data regarding the relationship between frailty and treatment adherence. A study carried out in Taiwan(²²) identified significantly worse adherence to treatment among non-frail patients, while researchers in Poland(¹⁷) found the highest frailty scores among older adult patients, being considered a determining factor of less adherence to treatment. As in this study, there are publications which do not report a correlation between frailty and adherence(¹²,²⁷).

In a Kosmonautów outpatient clinic in Wroclaw, Poland, it was proven that there was a negative association between frailty and medication adherence in older adult hypertensive patients; however, the authors state that studies on the presence of frailty syndrome and adherence in patients with hypertension have not been conducted so far(¹⁷).

Although there is no statistically significant relationship between adherence and frailty scores in Ribeirão Preto (SP), a study conducted in Poland points out that the early diagnosis of frailty and the difficulties associated with adherence to drug treatment by older adults allows inferring in the therapeutic conduct of those who are diagnosed with frailty and risk of cardiovascular complications due to untreated hypertension and then effectively plan interventions which will improve hypertension control(³¹).

As this is a cross-sectional study, it was not possible to state that there was a causal inference between the associations of the studied variables, but the methodological option enabled the objective to be answered and the results found were compatible with studies carried out in several countries. Another limitation which must be considered is the lower chance of the participation of men over 65 years of age because they have shorter survival when compared to women of the same age, as pointed out by a Brazilian study(⁴).

The theme is complex and involves several factors for non-adherence to medication treatment of hypertensive older adults; in this sense, the present study can contribute to the interdisciplinary practice of health professionals who provide care to older adults in different contexts of the health system and that they are aware of the factors which predispose them to poor adherence and frailty. Another way of stimulating adherence is the use of strategic actions in guidance groups carried out by health professionals and the inclusion of the family in the treatment in order to minimize difficulties, anxieties and promote patient adherence and safety in drug therapy.

CONCLUSION

The older adults in this study showed good adherence to antihypertensive treatment. Even though frailty did not result in a factor which interfered with adherence in this study, it is a syndrome which must be evaluated and monitored in older adults, as it is a risk predictor of cardiovascular diseases.

The nurse and the multidisciplinary team must have knowledge about the frailty syndrome, as it can be considered an independent and significant factor in low adherence to antihypertensive medication. Thus, considering that the higher the education of the older adult, the greater the contribution to good adherence to pharmacological treatment, adopting healthy habits can also contribute to better adherence of these people to the prescribed pharmacological treatments and a consequent improvement in blood pressure levels. Even though a direct relationship between frailty and adherence was not found, an early diagnosis of this syndrome can guide care which can prevent frailty in older adults and ensure adherence to therapeutic treatment.

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• Financial support:

  Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Process no. 305565/2016-8.

Publication Dates

• Publication in this collection
  21 Sept 2020
• Date of issue
  2020

History

• Received
  05 Nov 2018
• Accepted
  30 Sept 2019