IMAGES IN CLINICAL INFECTIOUS DISEASES
IDermatology, Clinical Hospital, Medicine Faculty of São Paulo University
IIHealth Institut and IIILauro Souza Lima Institut, Department of Health State of São Paulo; São Paulo, SP, Brazil E-mail: angelatrindade@uol.com.br
Case 1: A 43 year-old, white man presented with a four month-history of six plaques well-circumscribed. Laboratory results, including several serological tests, as well as a radiological investigation, were either negative or normal. The Mitsuda reaction was positive (9 mm). He was put on prednisone therapy and multi-drug therapy (MDT) with subsequent healing of the cutaneous lesions and improvement of the neuritis in about six months. The diagnostic hypothesis was reactional tuberculoid leprosy (Figure 1).
Case 2: A 23 year-old, mulatto man with a two-year history of prednisone treatment for bouts of nodules appearing over a macula who had been on treatment for tuberculoid leprosy with MDT-PB. Laboratory data, which included a search for other infectious diseases (HIV, HTLV-1 and 2, hepatitis B and C, syphilis, tuberculosis, and chest X-ray) was normal/negative. However his tuberculosis skin test (PPD) was strongly positive (30 mm), and the Mitsuda reaction was also positive (7 mm). A biopsy revealed a chronic granulomatous dermatitis with caseous necrosis. Although a search for M. tuberculosis was negative by immune-histochemistry and PCR, he received conventional anti-TB therapy, with improvement of the nodules and the infiltrative lesions. Hypotheses: Tuberculoid leprosy in one reaction with caseous necrosis or Tuberculosis and Tuberculoid leprosy?
Discussion: Various infectious/inflammatory diseases are associated with necrosis [1-3]. Caseous lesions are frequently seen in tuberculosis but are rare in leprosy granulomas [4]. In case 1, the corticotherapy may have accelerated the healing of the ulcers and limited the fibrinoid necrosis, avoiding the deleterious effects of exacerbated host cell-mediated immunity [5]. In case 2, the two-year persisting caseous necrosis could have been due to a reinfection partially controlled by rifampicine. The strongly-positive PPD might be due to a cross reactivity between M. tuberculosis and M. leprae. However, neural involvement, the histopathology, and the lack of other pathogens, point to a leprosy granulomatous reaction [6-8]. These cases illustrate the difficulties in establishing a definitive diagnosis of a chronic infectious disease, when it is accompanied by a strong cellular immunity response, usually resulting in complete elimination of the invading organisms [9-10]. This difficulty emphasizes the need for careful anamnesis and dermato-neurological examination, looking for areas of anesthesia and neural thickening, to establish the diagnosis of leprosy, while we await improvement in the laboratory diagnostic techniques for mycobacteria.
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Leprosy with necrosis in granulomatous reaction
Publication Dates
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Publication in this collection
09 Feb 2009 -
Date of issue
Oct 2008