Mobile health may improve evaluation of lower urinary tract symptoms

Gomes, Cristiano M.; Moromizato, Julyana K. M.; Ribeiro, Lucia S.

doi:10.1590/S1677-5538.IBJU.2021.0211.1

COMMENT

The evaluation of patients with lower urinary tract symptoms (LUTS) is primarily based on clinical history and physical examination. Measuring the frequency and severity of LUTS adds important information for the characterization and management of lower urinary tract disorders (¹, ²). Bladder diaries and uroflowmetry may be invaluable for symptom characterization. The recording of volume and time of each void by the patient is referred to as a frequency volume chart (FVC). Inclusion of information like fluid intake, use of pads, incontinence episodes or symptom severity is termed a bladder diary (¹).

The FVC provides data on total voided volume, day-time and night-time voiding frequency, nocturnal urinary volume and individual voided volumes. The maximum voided volume (MVV) is an important parameter of the voiding diary as it corresponds to the functional bladder capacity. It may be important to improve our understanding of bladder sensation, overactive bladder symptoms, polyuria and overflow incontinence (³). It may be used to clinically phenotype patients and help counseling regarding fluid intake and timed voiding (³). It may also assist in monitoring patient´s response to treatment (²). The amount of information to be included and the duration of a bladder diary is variable, but typically should take from three to seven days (⁴).

In this study, based on the perception that patients often have a greater MVV during office uroflowmetry than that seen in the bladder diary, the authors compared these two non-invasive methods by which MVV can be determined. They used a database of over seven hundred patients evaluated for LUTS who completed a 24-hour bladder diary independently using a smartphone application. They found that there is a difference between the two measurement tools, and that the maximum voided volume recorded in a bladder diary (BD-MVV) is usually greater than that obtained at the time of uroflow (Q-MVV). They suggested that for a more reliable assessment of MVV in men and women, both Q-MVV and BD-MVV should be assessed and that the larger of the two values is a more reliable assessment of MVV (⁵).

It is important to highlight the use of a mobile app for the completion of the voiding diary in this study.Mobile health (mHealth) is an attractive and expanding tendency within LUTS care, both from the viewpoint of urologists and also by health systems and for research (⁶, ⁷). Typically, mHealth is based on a smartphone app that may help in the evaluation, monitoring and/or treatment of a health condition. mHealth has been used in urology for prostate cancer, urinary stones, LUTS, urinary incontinence and urinary tract infections and its use has gained importance with the COVID-19 pandemic (⁸). In the urinary stone field, apps may prevent forgetting a double-J catheter (⁹). For prostate cancer, apps may help physicians to stage patients and calculate disease risk and they may help patients to track symptoms and medications and connect them to care providers (¹⁰).

We were not able to analyze the app used in this study because it is proprietary and not open to download. Many apps are available for urinary incontinence/LUTS and anyone can download some of these apps to their phones. Typically, apps in this ﬁeld allow for symptom evaluation and monitoring or guide patients on how and when to do pelvic floor exercises and lifestyle adaptations (¹¹). For doctors, apps may offer the possibility of improving the understanding of patient symptoms and might help selecting individualized diagnostic and treatment strategies. In addition, they may monitor patient’s progress and improve adherence to the treatment plan. Patients can have access to their progress and may become active participants in their own health care.

In spite of the interest in mhealth for UI/LUTS, a recent study evaluated the available apps in this field in Brazil and found that currently available tools are of poor quality (¹¹). Most have unattractive layouts, low-resolution graphics and low-quality information, from questionable sources. Authors cautioned that there is a lack of evidence-based scientiﬁc information associated with these apps and they credited that to the fact that most apps were developed for commercial purposes, suggesting the need to promote better partnership between industry and academic institutions to improve the quality of healthcare apps.

Similarly, a systematic review of apps for UI/LUTS in English language found that many of the available apps are of questionable quality, mostly not based on credible sources and/or scientific evidence (⁸). Authors emphasize that future app development should focus on enhancing overall quality while including evidence-based content; in addition, the inclusion of features that might help increasing adherence to treatment would be valuable.

We still have many obstacles before the widespread use of mhealth technologies becomes a reality, especially with the elderly population. The use of mobile apps may be limited by their extension and complexity of their commands. Ideally, they should be as short and straightforward as possible, enabling easy and rapid completion, which may help expand their usage and improve their accuracy (⁸, ¹¹, ¹²).

Improving the evidence-based scientiﬁc information attesting the efficacy of mHealth will be important to stimulate more practitioners and patients to adopt it. The present study represents one more step in this direction. If proven to be effective, apps providing evaluation and self-management of LUTS may increase access to care and reduce costs with treatment.

REFERENCES

¹ Gravas S, Cornu JN, Gacci M, Gratzke C, Herrmann TRW, Mamoulakis C, et al. EAU Guidelines on Management of Non-Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO) 2020, in European Association of Urology Guidelines. 2020 Edition. 2020, European Association of Urology Guidelines Office: Arnhem, The Netherlands. 2020. [Internet]. Available at. <https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Male-LUTS-incl.-BPO-2020.pdf>
» https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Male-LUTS-incl.-BPO-2020.pdf
² Harding CK, Lapitan MC, Arlandis S, Bø K, Costantini E, Groen J, et al. EAU Guidelines on Management of Non-Neurogenic Female Lower Urinary Tract Symptoms (LUTS), in European Association of Urology Guidelines. 2021 Edition. 2021, European Association of Urology Guidelines Office. 2021. [Internet]. Available at. <https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Female-LUTS-2021.pdf>
» https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Female-LUTS-2021.pdf
³ Blaivas JG, Li ESW, Dayan L, Edeson ME, Mathew J, O’Boyle AL, et al. Overactive bladder phenotypes: development and preliminary data. Can J Urol. 2021;28:10699-704.
⁴ Yap TL, Cromwell DC, Emberton M. A systematic review of the reliability of frequency-volume charts in urological research and its implications for the optimum chart duration. BJU Int. 2007;99:9-16.
⁵ Rychik K, Policastro L, Weiss J, Blaivas J. Relationship between maximum voided volume obtained by bladder diary compared to contemporaneous uroflowmetry in men and women. Int Braz J Urol. 2021;47; 1189-94.
⁶ Pereira Azevedo N, Gravas S, de la Rosette J. Mobile Health in Urology: The Good, the Bad and the Ugly. J Clin Med. 2020;9:1016.
⁷ Abrams P, Paty J, Martina R, Newgreen DT, van Maanen R, Paireddy A, et al. Electronic bladder diaries of differing duration versus a paper diary for data collection in overactive bladder. Neurourol Urodyn. 2016;35:743-9.
⁸ Novara G, Checcucci E, Crestani A, Abrate A, Esperto F, Pavan N, et al. Telehealth in Urology: A Systematic Review of the Literature. How Much Can Telemedicine Be Useful During and After the COVID-19 Pandemic? Eur Urol. 2020;78:786-11.
⁹ Ulker V, Atalay HA, Cakmak O, Yucel C, Celik O, Kozacioglu Z. Smartphone-based stent tracking application for prevention of forgotten ureteral double-J stents: a prospective study. Int Braz J Urol. 2019;45:376-83.
¹⁰ Pham Q, Cafazzo JA, Feifer A. Adoption, Acceptability, and Effectiveness of a Mobile Health App for Personalized Prostate Cancer Survivorship Care: Protocol for a Realist Case Study of the Ned App. JMIR Res Protoc. 2017;6:e197.
¹¹ Dantas LO, Carvalho C, Santos BLJ, Ferreira CHJ, Bø K, Driusso P, et al. Mobile health technologies for the management of urinary incontinence: A systematic review of online stores in Brazil. Braz J Phys Ther. 2021;25:387-95.
¹² Silva CS, de Araujo UM, Alvaia MA, Freitas KS, Tiraboschi TLN, Gomes CM, et al. A new simplified score for assessing lower urinary tract symptoms in men. Int Braz J Urol. 2021;47:525-32.

Publication Dates

Publication in this collection
01 Oct 2021
Date of issue
Nov-Dec 2021

History

Received
01 Aug 2021
Accepted
10 Aug 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

[1] ¹ Gravas S, Cornu JN, Gacci M, Gratzke C, Herrmann TRW, Mamoulakis C, et al. EAU Guidelines on Management of Non-Neurogenic Male Lower Urinary Tract Symptoms (LUTS), incl. Benign Prostatic Obstruction (BPO) 2020, in European Association of Urology Guidelines. 2020 Edition. 2020, European Association of Urology Guidelines Office: Arnhem, The Netherlands. 2020. [Internet]. Available at. <https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Male-LUTS-incl.-BPO-2020.pdf>
» https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Male-LUTS-incl.-BPO-2020.pdf

[2] ² Harding CK, Lapitan MC, Arlandis S, Bø K, Costantini E, Groen J, et al. EAU Guidelines on Management of Non-Neurogenic Female Lower Urinary Tract Symptoms (LUTS), in European Association of Urology Guidelines. 2021 Edition. 2021, European Association of Urology Guidelines Office. 2021. [Internet]. Available at. <https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Female-LUTS-2021.pdf>
» https://uroweb.org/wp-content/uploads/EAU-Guidelines-on-Non-Neurogenic-Female-LUTS-2021.pdf

[3] ³ Blaivas JG, Li ESW, Dayan L, Edeson ME, Mathew J, O’Boyle AL, et al. Overactive bladder phenotypes: development and preliminary data. Can J Urol. 2021;28:10699-704.

[4] ⁴ Yap TL, Cromwell DC, Emberton M. A systematic review of the reliability of frequency-volume charts in urological research and its implications for the optimum chart duration. BJU Int. 2007;99:9-16.

[5] ⁵ Rychik K, Policastro L, Weiss J, Blaivas J. Relationship between maximum voided volume obtained by bladder diary compared to contemporaneous uroflowmetry in men and women. Int Braz J Urol. 2021;47; 1189-94.

[6] ⁶ Pereira Azevedo N, Gravas S, de la Rosette J. Mobile Health in Urology: The Good, the Bad and the Ugly. J Clin Med. 2020;9:1016.

[7] ⁷ Abrams P, Paty J, Martina R, Newgreen DT, van Maanen R, Paireddy A, et al. Electronic bladder diaries of differing duration versus a paper diary for data collection in overactive bladder. Neurourol Urodyn. 2016;35:743-9.

[8] ⁸ Novara G, Checcucci E, Crestani A, Abrate A, Esperto F, Pavan N, et al. Telehealth in Urology: A Systematic Review of the Literature. How Much Can Telemedicine Be Useful During and After the COVID-19 Pandemic? Eur Urol. 2020;78:786-11.

[9] ⁹ Ulker V, Atalay HA, Cakmak O, Yucel C, Celik O, Kozacioglu Z. Smartphone-based stent tracking application for prevention of forgotten ureteral double-J stents: a prospective study. Int Braz J Urol. 2019;45:376-83.

[10] ¹⁰ Pham Q, Cafazzo JA, Feifer A. Adoption, Acceptability, and Effectiveness of a Mobile Health App for Personalized Prostate Cancer Survivorship Care: Protocol for a Realist Case Study of the Ned App. JMIR Res Protoc. 2017;6:e197.

[11] ¹¹ Dantas LO, Carvalho C, Santos BLJ, Ferreira CHJ, Bø K, Driusso P, et al. Mobile health technologies for the management of urinary incontinence: A systematic review of online stores in Brazil. Braz J Phys Ther. 2021;25:387-95.

[12] ¹² Silva CS, de Araujo UM, Alvaia MA, Freitas KS, Tiraboschi TLN, Gomes CM, et al. A new simplified score for assessing lower urinary tract symptoms in men. Int Braz J Urol. 2021;47:525-32.