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Síndrome de Parkinson e L-dopa

Treatment of parkinsonism with L-Dopa

Resumos

Os autores assinalam o efeito favorável da L-Dopa no tratamento da síndrome parkinsoniana, apresentados por 25 pacientes. Tecem considerações sobre os efeitos colaterais e resultados terapêuticos. Assinalam a presença de eosinofilia após o tratamento em alguns casos e chamam a atenção sobre dois casos que tiveram crises convulsivas durante o tratamento.


Encouraged by the recent literature on the subject, the authors decided to treat 18 patients in double-blind fashion using L-Dopa against a placebo during 4 weeks. Dosage was gradually increased from 0,5 g to 4 g within this four-week period. Afterwards the trial proceeded openly, all patients receiving L-Dopa. Further 7 patients were added, making up a total number of 25. The trial was carried on for further 8 weeks. Blood counts, liver function tests, urinalysis, ECG and EEG were performed. Eosinophilia, of which the origin could not be ascertained, was found in 8 cases, and generalised convulsions ocurred in two cases. By the 8th week of treatment 6 patients showed marked improvement; 12 had improved noticeably, and the remaining 7 were slightly better. Hyperkinesia and postural hypotension were controlled by dosage reduction. Four patients reported increase of sexual activity. The trial proceeds, a clinical reappraisal being foreseen for the 12th month of. treatment.


Síndrome de Parkinson e L-dopa

Treatment of parkinsonism with L-Dopa

Fernando PompeuI; Maier SztajnbergII; Ivan TeixeiraIII; Sérgio CarneiroII; Israel SchulzII; Sérgio RibeiroII; Hélder VasconcelosIV; Edimar AlbuquerqueV

IServiço de Neurologia do Hospital Estadual Miguel Couto (Guanabara): Chefe do Serviço

IIServiço de Neurologia do Hospital Estadual Miguel Couto (Guanabara): Assistentes

IIIServiço de Neurologia do Hospital Estadual Miguel Couto (Guanabara): Chefe de Clínica

IVServiço de Neurologia do Hospital Estadual Miguel Couto (Guanabara): Médico-estagiário

VServiço de Neurologia do Hospital Estadual Miguel Couto (Guanabara): Acadêmico

RESUMO

Os autores assinalam o efeito favorável da L-Dopa no tratamento da síndrome parkinsoniana, apresentados por 25 pacientes. Tecem considerações sobre os efeitos colaterais e resultados terapêuticos. Assinalam a presença de eosinofilia após o tratamento em alguns casos e chamam a atenção sobre dois casos que tiveram crises convulsivas durante o tratamento.

SUMMARY

Encouraged by the recent literature on the subject, the authors decided to treat 18 patients in double-blind fashion using L-Dopa against a placebo during 4 weeks. Dosage was gradually increased from 0,5 g to 4 g within this four-week period. Afterwards the trial proceeded openly, all patients receiving L-Dopa. Further 7 patients were added, making up a total number of 25. The trial was carried on for further 8 weeks. Blood counts, liver function tests, urinalysis, ECG and EEG were performed. Eosinophilia, of which the origin could not be ascertained, was found in 8 cases, and generalised convulsions ocurred in two cases. By the 8th week of treatment 6 patients showed marked improvement; 12 had improved noticeably, and the remaining 7 were slightly better. Hyperkinesia and postural hypotension were controlled by dosage reduction. Four patients reported increase of sexual activity. The trial proceeds, a clinical reappraisal being foreseen for the 12th month of. treatment.

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Serviço de Neurologia — Hospital Estadual Miguel Couto — Rua Mário Ribeiro s/n.º, Gávea — Rio de Janeiro, GB — Brasil

Trabalho do Serviço de Neurologia do Hospital Estadual Miguel Couto (Guanabara) apresentado no IV Congresso Brasileiro de Neurologia (julho de 1970, Porto Alegre, RS).

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Datas de Publicação

  • Publicação nesta coleção
    19 Abr 2013
  • Data do Fascículo
    Jun 1971
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