Coriocarcinoma manifestando-se inicialmente como um tumor cerebral

Silva, José Alberto G. da; Chaves, Ely

doi:10.1590/S0004-282X1971000300010

Resumos

Os autores descrevem um caso de coriocarcinoma cerebral metastático, removido cirurgicamente, ocorrendo numa paciente de 19 anos e localizado na porção posterior do lobo frontal esquerdo. Um estudo retrospectivo da paciente revelou apenas discreta perda sangüínea pelos genitais, iniciada algumas semanas após o delivramento de uma criança normal, ocorrido quatro meses antes. O exame colpocitológico da secreção cérvico-vaginal revelou uma classe V de Papanicolau (positivo para células neoplásicas malignas), tendo ulteriormente a paciente sido submetida à histerectomia total com anexectomia bilateral. Um pequeno tumor de aspecto hemorrágico-necrótico foi encontrado na cavidade uterina, tendo o exame histológico mostrado tratar-se de coriocarcinoma. Os autores tecem considerações clínico-patológicas sobre o coriocarcinoma. com especial referência às lesões metastáticas cerebrais.

A case of a metastatic cerebral chorioncarcinoma in the posterior aspect of the left frontal lobe of a 19-years-old woman is reported. After neurosurgical excision of the brain tumor a retrospective study of the patient was carried out as far as the gynecologic complaints were concerned. The patient complained only of little blood loss through the genitals started some weeks after the birth of a normal child four months ago. A smear vaginal preparation showed the presence of atypical epithelial cells (class V of Papanicolau). A total hysterectomy associated with bilateral anexectomy was performed. A small hemorrhagic tumor was detected within the uterus and a histological examination showed a chorioncarcinoma invading the miometrium. The clinico-pathological aspects of the chorioncarcinoma with special emphasis to cerebral metastases are discussed.

Coriocarcinoma manifestando-se inicialmente como um tumor cerebral

Metastatic cerebral chorioncarcinoma simulating a primary brain tumor

José Alberto G. da Silva^I; Ely Chaves^II

^IProfessor de Neurologia e Neurocirurgia na Fac. Med. Univ. Paraíba

^IIProfessor de Anatomia Patológica na Fac. Med. Univ. Paraíba e Chefe do Depart. Patologia, Hospital do Câncer Napoleão Laureano, Paraíba

RESUMO

Os autores descrevem um caso de coriocarcinoma cerebral metastático, removido cirurgicamente, ocorrendo numa paciente de 19 anos e localizado na porção posterior do lobo frontal esquerdo. Um estudo retrospectivo da paciente revelou apenas discreta perda sangüínea pelos genitais, iniciada algumas semanas após o delivramento de uma criança normal, ocorrido quatro meses antes. O exame colpocitológico da secreção cérvico-vaginal revelou uma classe V de Papanicolau (positivo para células neoplásicas malignas), tendo ulteriormente a paciente sido submetida à histerectomia total com anexectomia bilateral. Um pequeno tumor de aspecto hemorrágico-necrótico foi encontrado na cavidade uterina, tendo o exame histológico mostrado tratar-se de coriocarcinoma. Os autores tecem considerações clínico-patológicas sobre o coriocarcinoma. com especial referência às lesões metastáticas cerebrais.

SUMMARY

A case of a metastatic cerebral chorioncarcinoma in the posterior aspect of the left frontal lobe of a 19-years-old woman is reported. After neurosurgical excision of the brain tumor a retrospective study of the patient was carried out as far as the gynecologic complaints were concerned. The patient complained only of little blood loss through the genitals started some weeks after the birth of a normal child four months ago. A smear vaginal preparation showed the presence of atypical epithelial cells (class V of Papanicolau). A total hysterectomy associated with bilateral anexectomy was performed. A small hemorrhagic tumor was detected within the uterus and a histological examination showed a chorioncarcinoma invading the miometrium. The clinico-pathological aspects of the chorioncarcinoma with special emphasis to cerebral metastases are discussed.

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Hospital de Câncer Napoleão Laureano João Pessoa Paraíba Brasil.

1. ACOSTA-SISON, H. The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am. J. Obst. & Gynec. 75:1149, 1958.
2. AHUMADA, J. C; CHEVALIER, H. M. & SAMMARTINO, R. Corioncarcinomas. InEl Cancer Ginecológico. Ahumada et al., editores. El Ateneo, Madrid, 1953.
3. AINSWORTH, H. W. & GRESHAM, G. A. Primary chorioncarcinoma of the urinary bladder in the male. J. Path. Bact. 79:185, 1960.
4. BARZILAI, G. Atlas of Ovarian Tumors. Grune & Stratton, New York, 1943.
5. BEACHAM, D. W. & BEACHAM, W. D. Synopsis of Gynecology. C. V. Mosby Co, New York, 1967.
6. DIXON, F. J. & MOORE, R. A. Testicular tumors. A clinico-pathological study. Cancer 6:427, 1953.
7. DOCKERTY, W. C. & MCK CRAIG, W. Chorionepithelioma. An unnusual case in which cerebral metatasis occurred four years after hysterectomy. Amer. J. Obst. & Gynec. 44:497, 1942.
8. DOUGAL, D. Chorionepithelioma of the ovary. J. Obst. Gynaec. Brit. Emp. 31:387, 1924.
9. FORTHER, H. C. & OWEN, S. E. Chorionepithelioma in the male. Amer. J. Cancer 25:89, 1935.
10. FRIEDMAN, N. B. & MOORE, R. A. Tumors of testis: a report on 992 cases. Milit. Surg. 99:573, 1946.
11. HERTIG, H. T. & MANSELL, H. Tumors of the Female Sex Organs. Part, I Hydatiform mole and Chorioncarcinoma. Atlas of Tumor Pathology, section IX, fascicle 33. Armed Forces Institute of Pathology, Washington D.C., 1956.
12. HERTZ, H.; ROSS, G. T. & LIPSETT, M. B. Chemotherapy in women with trophoblastic disease: chorioncarcinoma, chorioadenoma destruens and complicated hydatiform mole. Ann. N. Y. Acad. Sci. 114:881, 1964.
13. LAMBE, J.; MORTON, D. G. & BYRON, R. C. Methotrexate therapy of chorioncarcinoma and allied tumors. Amer. J. Obst. & Gynec. 90:317, 1964.
14. LI, M. C.; HERTZ, R. & SPENCER, D. B. Effect of methotrexate therapy upon chorioncarcinoma and chorionadenoma. Proc. Soc. Exper. Biol. Med. 93: 361, 1956.
15. MARRUBINI, G. Primary chorionepithelioma of the ovary: report of two cases. Acta obstet, gynec. scand. 28:251, 1948-1949.
16. MOORE, R. M. Hormonal aspects and diagnosis of trophoblastic tumors. InNew Concepts in Gynecological Oncology. Lewin-Wentz-Jaffe, editors, F. A. Davis Co., New York, 1966.
17. NOVAK, E. & SEAH, C. S. Chorioncarcinoma of the uterus. Study of 74 cases from the Mathieu Memorial Chorionepithelioma Registry. Amer. J. Obstet. & Gynec. 67:933, 1954.
18. OLIVER, H. M. & HORNE, E. O. Primary teratomatous chorionepithelioma of the ovary: report of a case. New England J. Med. 239:14, 1948.
19. PARK, W. W. & LEES, J. C. Chorioncarcinoma. A general review with an analysis of 516 cases. Arch. Path. 49:104, 1950.
20. PEREIRA, W. C.; MATTOSINHO-FRANÇA, L. C.; TENUTO, R. A. & EPPS, D. Teratocorioepiteliomas: relato de um intracraniano e outro ovariano. Maternidade e Infância (São Paulo) 25:117, 1966.
21. PUGSLEY, W. S. & CARLETON, R. L. Germinal nature of teratoid tumors of the thymus. Arch. Path. 56:341, 1953.
22. VOGLER, W. R.; HUGULEY, C. M. & KERR, W. Toxicity and anti-tumor effect of divided doses of methotrexate. Intern. J. Med. 115:285, 1965.

Datas de Publicação

Publicação nesta coleção
19 Abr 2013
Data do Fascículo
Set 1971

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ACOSTA-SISON, H. The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am. J. Obst. & Gynec. 75:1149, 1958.

[2] 2. AHUMADA, J. C; CHEVALIER, H. M. & SAMMARTINO, R. Corioncarcinomas. InEl Cancer Ginecológico. Ahumada et al., editores. El Ateneo, Madrid, 1953.

[3] 3. AINSWORTH, H. W. & GRESHAM, G. A. Primary chorioncarcinoma of the urinary bladder in the male. J. Path. Bact. 79:185, 1960.

[4] 4. BARZILAI, G. Atlas of Ovarian Tumors. Grune & Stratton, New York, 1943.

[5] 5. BEACHAM, D. W. & BEACHAM, W. D. Synopsis of Gynecology. C. V. Mosby Co, New York, 1967.

[6] 6. DIXON, F. J. & MOORE, R. A. Testicular tumors. A clinico-pathological study. Cancer 6:427, 1953.

[7] 7. DOCKERTY, W. C. & MCK CRAIG, W. Chorionepithelioma. An unnusual case in which cerebral metatasis occurred four years after hysterectomy. Amer. J. Obst. & Gynec. 44:497, 1942.

[8] 8. DOUGAL, D. Chorionepithelioma of the ovary. J. Obst. Gynaec. Brit. Emp. 31:387, 1924.

[9] 9. FORTHER, H. C. & OWEN, S. E. Chorionepithelioma in the male. Amer. J. Cancer 25:89, 1935.

[10] 10. FRIEDMAN, N. B. & MOORE, R. A. Tumors of testis: a report on 992 cases. Milit. Surg. 99:573, 1946.

[11] 11. HERTIG, H. T. & MANSELL, H. Tumors of the Female Sex Organs. Part, I Hydatiform mole and Chorioncarcinoma. Atlas of Tumor Pathology, section IX, fascicle 33. Armed Forces Institute of Pathology, Washington D.C., 1956.

[12] 12. HERTZ, H.; ROSS, G. T. & LIPSETT, M. B. Chemotherapy in women with trophoblastic disease: chorioncarcinoma, chorioadenoma destruens and complicated hydatiform mole. Ann. N. Y. Acad. Sci. 114:881, 1964.

[13] 13. LAMBE, J.; MORTON, D. G. & BYRON, R. C. Methotrexate therapy of chorioncarcinoma and allied tumors. Amer. J. Obst. & Gynec. 90:317, 1964.

[14] 14. LI, M. C.; HERTZ, R. & SPENCER, D. B. Effect of methotrexate therapy upon chorioncarcinoma and chorionadenoma. Proc. Soc. Exper. Biol. Med. 93: 361, 1956.

[15] 15. MARRUBINI, G. Primary chorionepithelioma of the ovary: report of two cases. Acta obstet, gynec. scand. 28:251, 1948-1949.

[16] 16. MOORE, R. M. Hormonal aspects and diagnosis of trophoblastic tumors. InNew Concepts in Gynecological Oncology. Lewin-Wentz-Jaffe, editors, F. A. Davis Co., New York, 1966.

[17] 17. NOVAK, E. & SEAH, C. S. Chorioncarcinoma of the uterus. Study of 74 cases from the Mathieu Memorial Chorionepithelioma Registry. Amer. J. Obstet. & Gynec. 67:933, 1954.

[18] 18. OLIVER, H. M. & HORNE, E. O. Primary teratomatous chorionepithelioma of the ovary: report of a case. New England J. Med. 239:14, 1948.

[19] 19. PARK, W. W. & LEES, J. C. Chorioncarcinoma. A general review with an analysis of 516 cases. Arch. Path. 49:104, 1950.

[20] 20. PEREIRA, W. C.; MATTOSINHO-FRANÇA, L. C.; TENUTO, R. A. & EPPS, D. Teratocorioepiteliomas: relato de um intracraniano e outro ovariano. Maternidade e Infância (São Paulo) 25:117, 1966.

[21] 21. PUGSLEY, W. S. & CARLETON, R. L. Germinal nature of teratoid tumors of the thymus. Arch. Path. 56:341, 1953.

[22] 22. VOGLER, W. R.; HUGULEY, C. M. & KERR, W. Toxicity and anti-tumor effect of divided doses of methotrexate. Intern. J. Med. 115:285, 1965.