HTLV-I associated myelopathy / tropical spastic paraparesis: report of the first cases in Rio Grande do Sul, Brazil

Haussen, Sérgio Roberto; Vecino, Maria Cecilia de

doi:10.1590/S0004-282X1995000400010

Abstracts

The HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), a myelopathy with predominant involvement of the pyramidal tract with minimal sensory loss and associated with HTLV-I infection, endemic in tropical areas, has been identified in four patients in Porto Alegre (RS, Brazil), a temperate zone.

HTLV-1 associated myelopathy; tropical spastic paraparesis; HTLV-I; Rio Grande do Sul (Brazil)

A mielopatia associada ao HTLV-I/paraparesia espástica tropical (HAM/TSP), uma mielopatia com envolvimento predominante do trato piramidal e com perda sensitiva mínima, que tem o vírus HTLV-I como agente etiológico e é endêmica em várias áreas tropicais, foi identificada em quatro pacientes em Porto Alegre (RS, Brasil), uma zona temperada.

mielopatia associada ao HTLV-I; paraparesia espástica tropical; HTLV-I; Rio Grande do Sul (Brasil)

HTLV-I associated myelopathy / tropical spastic paraparesis. Report of the first cases in Rio Grande do Sul, Brazil

Mielopatia associada ao HTLV-I/paraparesia espástica tropical: relato dos primeiros casos no Rio Grande do Sul, Brasil

Sérgio Roberto Haussen^I; Maria Cecilia de Vecino^II

^IProfessor and Chairman of Neurology of FFFCMPA, Director of ISCMPA. From the Instituto de Neurologia da Irmandade da Santa Casa de Misericórdia de Porto Alegre (INSCMPA), Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (FFFCMPA) and Serviço de Neurologia do Hospital de Clínicas de Porto Alegre (HCPA) da Universidade Federal do Rio Grande do Sul (UFRS)

^IINeurologist at Neuro-Immunology Clinic of HCPA and INISCMPA, Graduate Student for the Master of Science Degree in Internal Medicine of UFRS. From the Instituto de Neurologia da Irmandade da Santa Casa de Misericórdia de Porto Alegre (INSCMPA), Fundação Faculdade Federal de Ciências Médicas de Porto Alegre (FFFCMPA) and Serviço de Neurologia do Hospital de Clínicas de Porto Alegre (HCPA) da Universidade Federal do Rio Grande do Sul (UFRS)

SUMMARY

The HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP), a myelopathy with predominant involvement of the pyramidal tract with minimal sensory loss and associated with HTLV-I infection, endemic in tropical areas, has been identified in four patients in Porto Alegre (RS, Brazil), a temperate zone.

Key words:HTLV-1 associated myelopathy, tropical spastic paraparesis, HTLV-I, Rio Grande do Sul (Brazil).

RESUMO

A mielopatia associada ao HTLV-I/paraparesia espástica tropical (HAM/TSP), uma mielopatia com envolvimento predominante do trato piramidal e com perda sensitiva mínima, que tem o vírus HTLV-I como agente etiológico e é endêmica em várias áreas tropicais, foi identificada em quatro pacientes em Porto Alegre (RS, Brasil), uma zona temperada.

Palavras-chave: mielopatia associada ao HTLV-I, paraparesia espástica tropical, HTLV-I, Rio Grande do Sul (Brasil).

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 6-maio-1995.

Part of this study was presented at the XV Congresso Brasileiro de Neurologia, Porto Alegre RS, Brazil, October 10-15, 1992; Abstract in: Arq Neuropsiquiatr 1992, 50 (Supl):80.

Dra. Maria Cecília de Vecino - Rua Felipe Camarão 147/62 - 90035-141- Porto Alegre RS - Brasil

1. Araújo AQC, Afonso CR, Leite ACB, Dultra SV. Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) Arq Neuropsiquiatr 1993; 51:325-328.
2. Araújo AQC, Afonso CR, Schor D, Leite AC, Andrada Serpa MJ. Clinical and demographic features of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brasil. Acta Neurol Scand 1993; 88:59-62.
3. Araújo AQC, Ali A, Newell A, Dalgleish AG, Rudge P. HTLV-I infection and neurological disease in Rio de Janeiro. J Neurol Neurosurg Psychiatry 1992, 55:153-155.
4. Castro LHM, Chaves CJ, Callegaro D, Nóbrega JPS, Scaff M. Arq Neuropsiquiatr 1989; 47:501-502.
5. Costa CM, Salgueiro MR, Carton H, Vale OC, Arruda AM. Tropical spastic paraparesis in north-eastern Brazil. Arq. Neuropsiquiatr, 1989; 47:134-138.
6. Cruickshank JK, Rudge P, Dalgleish AG, Newton M, McLean BN, Barnard RO, Kendll BE, Miller DH. Tropical spastic paraparesis and human T-cell lymphotropic virus type I in the United Kingdom. Brain 1989; 112:1057-1090.
7. Gout O, Gessain A. Rapid development of myelopathy after HTLV-I infection acquired by transfusion during cardiac transplantation. N Engl J Med 1990; 322:383-388.
8. Gout O, Gessain A, Bolger F, Saal F. Tournier-Lasserve E, Lasneret J, Candie C, Brunet P, De-Thé G, Lhermitte F, Lyon-Caen O. Chronic myelopathies associated with human T-lymphotropic virus type I. Ann Neurol 1989; 46:255-260.
9. Johnson RT, Griffin DE, Arregui A, Mora C, Gibbs CJ Jr, Cuba JM, Trelles L, Vaisberg A. Spastic paraparesis and HTLV-I infection in Peru. Ann Neurol 1988; 23:S151-S155.
10. Kayembe K, Goubau P, Desmyter J, Vlietinck R, Carton H. A Cluster of HTLV-I associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution. J Neurol Neurosurg Psychiatry 1990; 53:4-10.
11. Leehey M, Gilden D. Neurologic disorders associated with the HIV and HTLV-I virus. Curr Neurol 1990; 10:1-63.
12. Melo A, Moura L, Rios S, Machado M, Costa G. Magnetic resonance imaging in HTLV-1 associated myelopathy. Arq Neuropsiquiatr 1993, 51:329-332.
13. Mattos K, Queiroz C, Peçanha-Martins AC, Publio L, Vinhas V, Melo A. Lymphocyte alveolitis in HAM/ TSP patients. Arq Neuropsiquiatr 1993; 51:134-136.
14. Osame M, Igata A, Matsumoto M, Koichiro U, Izumo S, Kosaka K. HTLV-I associated myelopathy: a report of 85 cases. Ann Neurol 1987; 22:116.
15. Osame M, Jansen R, Igata A, Kaplan J. Nationwide survey of HTLV-1 associated myelopathy in Japan: association with blood transfusion. Ann Neurol 1990; 28:50-56.
16. Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988; 23:S113-S120.
17. Spina-França A, Livramento JA, Machado LR, Gomes HR, Vianna LS, Castro LHM. Nóbrega JPS, Bacheschi LA. HTLV-I antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil. Arq. Neuropsiquiatr 1990; 48:441-447.
18. Tadokoro H, KitagawaT, Fujishita M, Taguchi H, Miyoshi I. Antibodies to HTLV-I in Japanese immigrant in Brazil. JAMA 1986; 256:2342.
19. Vernant JC, Maurs L, Gessain A, Barin F, Gout O, Delaporte JM, Sanhadji K, Buisson G, De-Thé G. Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol 1987; 21:123-130.
20. Zaninovic V. Retrovirus humanos. Cali: Feriva Editores, 1989, p 53-169.

Publication Dates

Publication in this collection
20 Dec 2010
Date of issue
Sept 1995

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Araújo AQC, Afonso CR, Leite ACB, Dultra SV. Intravenous methylprednisolone in HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) Arq Neuropsiquiatr 1993; 51:325-328.

[2] 2. Araújo AQC, Afonso CR, Schor D, Leite AC, Andrada Serpa MJ. Clinical and demographic features of HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brasil. Acta Neurol Scand 1993; 88:59-62.

[3] 3. Araújo AQC, Ali A, Newell A, Dalgleish AG, Rudge P. HTLV-I infection and neurological disease in Rio de Janeiro. J Neurol Neurosurg Psychiatry 1992, 55:153-155.

[4] 4. Castro LHM, Chaves CJ, Callegaro D, Nóbrega JPS, Scaff M. Arq Neuropsiquiatr 1989; 47:501-502.

[5] 5. Costa CM, Salgueiro MR, Carton H, Vale OC, Arruda AM. Tropical spastic paraparesis in north-eastern Brazil. Arq. Neuropsiquiatr, 1989; 47:134-138.

[6] 6. Cruickshank JK, Rudge P, Dalgleish AG, Newton M, McLean BN, Barnard RO, Kendll BE, Miller DH. Tropical spastic paraparesis and human T-cell lymphotropic virus type I in the United Kingdom. Brain 1989; 112:1057-1090.

[7] 7. Gout O, Gessain A. Rapid development of myelopathy after HTLV-I infection acquired by transfusion during cardiac transplantation. N Engl J Med 1990; 322:383-388.

[8] 8. Gout O, Gessain A, Bolger F, Saal F. Tournier-Lasserve E, Lasneret J, Candie C, Brunet P, De-Thé G, Lhermitte F, Lyon-Caen O. Chronic myelopathies associated with human T-lymphotropic virus type I. Ann Neurol 1989; 46:255-260.

[9] 9. Johnson RT, Griffin DE, Arregui A, Mora C, Gibbs CJ Jr, Cuba JM, Trelles L, Vaisberg A. Spastic paraparesis and HTLV-I infection in Peru. Ann Neurol 1988; 23:S151-S155.

[10] 10. Kayembe K, Goubau P, Desmyter J, Vlietinck R, Carton H. A Cluster of HTLV-I associated tropical spastic paraparesis in Equateur (Zaire): ethnic and familial distribution. J Neurol Neurosurg Psychiatry 1990; 53:4-10.

[11] 11. Leehey M, Gilden D. Neurologic disorders associated with the HIV and HTLV-I virus. Curr Neurol 1990; 10:1-63.

[12] 12. Melo A, Moura L, Rios S, Machado M, Costa G. Magnetic resonance imaging in HTLV-1 associated myelopathy. Arq Neuropsiquiatr 1993, 51:329-332.

[13] 13. Mattos K, Queiroz C, Peçanha-Martins AC, Publio L, Vinhas V, Melo A. Lymphocyte alveolitis in HAM/ TSP patients. Arq Neuropsiquiatr 1993; 51:134-136.

[14] 14. Osame M, Igata A, Matsumoto M, Koichiro U, Izumo S, Kosaka K. HTLV-I associated myelopathy: a report of 85 cases. Ann Neurol 1987; 22:116.

[15] 15. Osame M, Jansen R, Igata A, Kaplan J. Nationwide survey of HTLV-1 associated myelopathy in Japan: association with blood transfusion. Ann Neurol 1990; 28:50-56.

[16] 16. Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988; 23:S113-S120.

[17] 17. Spina-França A, Livramento JA, Machado LR, Gomes HR, Vianna LS, Castro LHM. Nóbrega JPS, Bacheschi LA. HTLV-I antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil. Arq. Neuropsiquiatr 1990; 48:441-447.

[18] 18. Tadokoro H, KitagawaT, Fujishita M, Taguchi H, Miyoshi I. Antibodies to HTLV-I in Japanese immigrant in Brazil. JAMA 1986; 256:2342.

[19] 19. Vernant JC, Maurs L, Gessain A, Barin F, Gout O, Delaporte JM, Sanhadji K, Buisson G, De-Thé G. Endemic tropical spastic paraparesis associated with human T-lymphotropic virus type I: a clinical and seroepidemiological study of 25 cases. Ann Neurol 1987; 21:123-130.

[20] 20. Zaninovic V. Retrovirus humanos. Cali: Feriva Editores, 1989, p 53-169.