Darkening of white hair in Parkinson's disease during use of levodopa rich Mucuna pruriens extract powder

Escurecimento do cabelo branco na doença de Parkinson durante tratamento com extrato em pó de Mucuna pruriens rico em levodopa

IMAGES IN NEUROLOGY

Darkening of white hair in Parkinson's disease during use of levodopa rich Mucuna pruriens extract powder

Escurecimento do cabelo branco na doença de Parkinson durante tratamento com extrato em pó de Mucuna pruriens rico em levodopa

Renato P Munhoz^I; Hélio A G Teive^II

^IMD MSc at State of Paraná Parkinson Association, Curitiba PR, Brazil

^IIMD PhD at Movement Disorders Unit, Neurology Service, Universidade Federal do Paraná (UFPR), Curitiba PR, Brazil

^{Correspondence}

An 85-year-old patient with stable Parkinson's disease (PD), treated with levodopa/carbidopa 250/25 mg tid. During a follow-up visit, it was noticed that her temporal white hair was getting progressively darker (Figure), starting after introduction of Mucuna pruriens extract (MPE) at a dose equivalent to 1000 mg of levodopa/day. Hair and beard darkening was recognized as a complication of treatment with levodopa in PD since its earliest introduction.¹ DOPA/dopamine are intermediate metabolites in the production of melanin, therefore, this association is not surprising. After the addition of decarboxylase inhibitors, this phenomenon, probably related to peripheral effects of levodopa, became strikingly rare.

Received: 12 September 2012

Received in final form: 20 September 2012

Accepted: 27 September 2012

Conflict of interest: There is no conflict of interest to declare.

• 1. Reynolds NJ, Crossley J, Ferguson I, Peachey RD. Darkening of white hair in Parkinson's disease. Clin Exp Dermatol 1989;14:317-318.

Publication Dates

• Publication in this collection
  05 Feb 2013
• Date of issue
  Feb 2013